Early Detection of Breast Cancer by Molecular Analysis of Ductal Lavage Fluid

2002 ◽  
Author(s):  
Saraswati Sukumar
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Molecular Analysis ◽  
Lavage Fluid ◽  
Ductal Lavage

Biomarker Analysis on Ductal Lavage Fluid as a Tool for Breast Cancer Early Detection

2002 ◽  
Author(s):  
Jian Y. Rao ◽  
Wei Zhang ◽  
BaoNing Zhang ◽  
Qinjing Pan ◽  
Karen Duvall
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Lavage Fluid ◽  
Ductal Lavage ◽  
Breast Cancer Early Detection ◽  
Cancer Early Detection ◽  
Biomarker Analysis

Identification of Biomarkers for Breast Cancer in Nipple Aspiration and Ductal Lavage Fluid

2005 ◽  
Vol 11 (23) ◽  
pp. 8312-8320 ◽  
Author(s):  
Jinong Li ◽  
Jing Zhao ◽  
Xiaodong Yu ◽  
Julie Lange ◽  
Henry Kuerer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lavage Fluid ◽  
Ductal Lavage ◽  
Nipple Aspiration

scholarly journals Relation of hormones in ductal lavage fluid to age, tamoxifen treatment, and breast cancer risk

2009 ◽  
Vol 3 (S5) ◽  
Author(s):  
RT Chatterton ◽  
MJ Avram ◽  
I Helenowski ◽  
M Bryk ◽  
SA Khan
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Lavage Fluid ◽  
Ductal Lavage ◽  
Tamoxifen Treatment

scholarly journals Breast Ductal Secretions: Clinical Features, Potential Uses, and Possible Applications

2007 ◽  
Vol 14 (4) ◽  
pp. 350-359 ◽  
Author(s):  
Julie E. Lang ◽  
Henry M. Kuerer
Keyword(s):  
Breast Cancer ◽  
Nipple Discharge ◽  
Lavage Fluid ◽  
Ductal Lavage ◽  
Breast Cancers ◽  
Ductal System ◽  
Nipple Aspiration ◽  
Biomarker Analysis ◽  
Risk Patients ◽  
Genomic Gene

Background Nipple discharge accounts for approximately 5% of visits to a breast specialist surgical practice and may be encountered as the chief complaint by many other types of physicians. The vast majority of breast cancers originate in the ductal system, which prompted interest in the evaluation of the intraductal approach to breast cancer. Ductoscopy, nipple aspiration, and ductal lavage have emerged as innovative fields of study that may have clinical applications. Methods We performed a literature search of published manuscripts using the keywords nipple discharge, breast ductal secretions, and intraductal approach. We also report our single-institution experience in managing nipple discharge. Results We present our institutional algorithm for the management of nipple discharge. The possible etiologies of nipple discharge and the appropriate workup are reviewed. Three evolving minimally invasive techniques for the evaluation of high-risk patients include ductoscopy, nipple aspiration, and ductal lavage. Nipple aspiration and ductal lavage fluid may be assayed for cytology, genomic, gene expression, and proteomic studies. Several different translational approaches are being undertaken to investigate the local microenvironment associated with the development and progression of breast carcinoma. Conclusions Nipple aspiration fluid and ductal lavage offer the opportunity to study the local microenvironment of the ductal system, which is where most breast cancers originate. These powerful approaches to biomarker analysis could be applied to the prevention and treatment of breast cancer.

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR

The Lancet ◽  
2001 ◽  
Vol 357 (9265) ◽  
pp. 1335-1336 ◽  
Author(s):  
Ella Evron ◽  
William C Dooley ◽  
Christopher B Umbricht ◽  
Dorothy Rosenthal ◽  
Nicoletta Sacchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Lavage Fluid ◽  
Ductal Lavage ◽  
Methylation Specific Pcr ◽  
Specific Pcr
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