The Role of Estrogen Receptor alpha K303R Mutation in Breast Cancer Metastasis

2003 ◽  
Author(s):  
Yukun Cui ◽  
Suzanne A. Fuqua
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Receptor Alpha

scholarly journals Obesity-Altered Adipose Stem Cells Promote ER+ Breast Cancer Metastasis through Estrogen Independent Pathways

2019 ◽  
Vol 20 (6) ◽  
pp. 1419 ◽  
Author(s):  
Rachel A. Sabol ◽  
Adam Beighley ◽  
Paulina Giacomelli ◽  
Rachel M. Wise ◽  
Mark A. A. Harrison ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Estrogen Receptor ◽  
Tumor Growth ◽  
Estrogen Receptor Alpha ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Adipose Stem Cells ◽  
Estrogen Signaling ◽  
Promote Tumor Growth

Adipose stem cells (ASCs) play an essential role in tumor microenvironments. These cells are altered by obesity (obASCs) and previous studies have shown that obASCs secrete higher levels of leptin. Increased leptin, which upregulates estrogen receptor alpha (ERα) and aromatase, enhances estrogen bioavailability and signaling in estrogen receptor positive (ER+) breast cancer (BC) tumor growth and metastasis. In this study, we evaluate the effect of obASCs on ER+BC outside of the ERα signaling axis using breast cancer models with constitutively active ERα resulting from clinically relevant mutations (Y537S and D538G). We found that while obASCs promote tumor growth and proliferation, it occurs mostly through abrogated estrogen signaling when BC has constitutive ER activity. However, obASCs have a similar promotion of metastasis irrespective of ER status, demonstrating that obASC promotion of metastasis may not be completely estrogen dependent. We found that obASCs upregulate two genes in both ER wild type (WT) and ER mutant (MUT) BC: SERPINE1 and ABCB1. This study demonstrates that obASCs promote metastasis in ER WT and MUT xenografts and an ER MUT patient derived xenograft (PDX) model. However, obASCs promote tumor growth only in ER WT xenografts.

scholarly journals The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells

2012 ◽  
Vol 31 (1) ◽  
pp. 42 ◽  
Author(s):  
Zhinong Jiang ◽  
Junlan Guo ◽  
Jianguo Shen ◽  
Mei Jin ◽  
Shuduo Xie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

176 Is there a role of DNA methylation in Estrogen Receptor alpha (ERa) expression in Breast Cancer (BC)?

2010 ◽  
Vol 8 (5) ◽  
pp. 46
Author(s):  
K. Desiris ◽  
S. Voyatzi ◽  
S. Theodosiadi ◽  
A. Ananiadis ◽  
P. Tsioulas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

scholarly journals Critical Role of Estrogen Receptor Alpha O-Glycosylation by N-Acetylgalactosaminyltransferase 6 (GALNT6) in Its Nuclear Localization in Breast Cancer Cells

Neoplasia ◽  
2018 ◽  
Vol 20 (10) ◽  
pp. 1038-1044 ◽  
Author(s):  
Boya Deng ◽  
Yunus Emre Tarhan ◽  
Koji Ueda ◽  
Lili Ren ◽  
Toyomasa Katagiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Nuclear Localization ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Critical Role ◽  
Receptor Alpha
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