Pim Protein Kinase-Levels Correlate With Prostate Tumor Growth and Chemo Resistance-Potential Mechanisms

2007 ◽  
Author(s):  
Andrew Kraft
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Prostate Tumor

scholarly journals Enhanced Inhibition of Prostate Tumor Growth by Dual Targeting the Androgen Receptor and the Regulatory Subunit Type Iα of Protein Kinase A in Vivo

2013 ◽  
Vol 14 (6) ◽  
pp. 11942-11962 ◽  
Author(s):  
Iris Eder ◽  
Martina Egger ◽  
Hannes Neuwirt ◽  
Christof Seifarth ◽  
Danilo Maddalo ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Protein Kinase ◽  
Tumor Growth ◽  
Protein Kinase A ◽  
Prostate Tumor ◽  
Regulatory Subunit ◽  
Dual Targeting ◽  
Kinase A

442: Stromal Hedgehog Pathway Activity Accelerates Prostate Tumor Growth

2006 ◽  
Vol 175 (4S) ◽  
pp. 143-143
Author(s):  
Aubie Shaw ◽  
Jerry Gipp ◽  
Wade Bushman
Keyword(s):  
Tumor Growth ◽  
Prostate Tumor ◽  
Hedgehog Pathway ◽  
Pathway Activity

Role of Protein kinase D2 in pancreatic tumor growth and tumor angiogenesis

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
N Azoitei ◽  
GV Pusapati ◽  
A Kleger ◽  
C Brunner ◽  
F Genze ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Pancreatic Tumor

scholarly journals The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion

Oncogene ◽  
2021 ◽  
Author(s):  
Qiuping Xu ◽  
Jingwei Zhang ◽  
Brian A. Telfer ◽  
Hao Zhang ◽  
Nisha Ali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Tumor Growth ◽  
Focal Adhesion ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Metastatic Breast ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

AbstractThere is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) is significantly dysregulated in human breast cancer. However, there is no definite understanding of the requirement of ERK5 in tumor growth and metastasis due to very limited characterization of the pathway in disease models. In this study, we report that a high level of ERK5 is a predictive marker of metastatic breast cancer. Mechanistically, our in vitro data revealed that ERK5 was critical for maintaining the invasive capability of triple-negative breast cancer (TNBC) cells through focal adhesion protein kinase (FAK) activation. Specifically, we found that phosphorylation of FAK at Tyr397 was controlled by a kinase-independent function of ERK5. Accordingly, silencing ERK5 in mammary tumor grafts impaired FAK phosphorylation at Tyr397 and suppressed TNBC cell metastasis to the lung without preventing tumor growth. Collectively, these results establish a functional relationship between ERK5 and FAK signaling in promoting malignancy. Thus, targeting the oncogenic ERK5-FAK axis represents a promising therapeutic strategy for breast cancer exhibiting aggressive clinical behavior.

scholarly journals Prostate Tumor Growth and Recurrence Can Be Modulated by the ω-6:ω-3 Ratio in Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy

Neoplasia ◽  
2006 ◽  
Vol 8 (2) ◽  
pp. 112-124 ◽  
Author(s):  
Uddhav P. Kelavkar ◽  
Justin Hutzley ◽  
Rajiv Dhir ◽  
Paul Kim ◽  
Kenneth G.D. Allen ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Tumor Growth ◽  
Xenograft Model ◽  
Prostate Tumor ◽  
Athymic Mouse ◽  
Mouse Xenograft ◽  
Mouse Xenograft Model

scholarly journals Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis

2009 ◽  
Vol 8 (3) ◽  
pp. 509-520 ◽  
Author(s):  
Girish V. Shah ◽  
Anbalagan Muralidharan ◽  
Shibu Thomas ◽  
Mitan Gokulgandhi ◽  
Mudit Mudit ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Growth ◽  
Small Molecule ◽  
Prostate Tumor ◽  
Tumor Growth And Metastasis ◽  
Cell Cell

scholarly journals CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

2009 ◽  
Vol 106 (9) ◽  
pp. 3414-3419 ◽  
Author(s):  
M. Augsten ◽  
C. Hagglof ◽  
E. Olsson ◽  
C. Stolz ◽  
P. Tsagozis ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Growth ◽  
Prostate Tumor ◽  
Autocrine Growth ◽  
Autocrine Growth Factor
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