Improving Joint Function Using Photochemical Hydrogels for Articular Surface Repair

2012 ◽  
Author(s):  
Thomas J. Gill
Keyword(s):  
Articular Surface ◽  
Joint Function ◽  
Surface Repair

Traumatic craniolateral shoulder luxation and fracture of the lesser tubercle of the humerus in a dog

2011 ◽  
Vol 24 (06) ◽  
pp. 474-477 ◽  
Author(s):  
M. S. Bergh ◽  
J. L. Huck
Keyword(s):  
Surgical Repair ◽  
Articular Surface ◽  
Weight Bearing ◽  
Complete Healing ◽  
Joint Function ◽  
Thoracic Limb ◽  
Anatomic Reduction ◽  
History Of ◽  
The Right ◽  
Displaced Fracture

SummaryA five-year old, spayed female, Bearded Collie was presented with a 24-hour history of non-weight-bearing lameness of the right thoracic limb after sustaining vehicular trauma. Radio-graphs revealed a craniolateral scapulohumeral luxation and a distally and medially displaced fracture of the lesser tubercle of the humerus. Open reduction and internal fixation of the fracture was achieved with lag screw fixation and an anti-rotational Kirsch-ner wire. Surgical repair resulted in compression across the fracture line, anatomic reduction of the articular surface, and a stable scapulohumeral joint following reduction of the humeral head in the glenoid. Six weeks postoperatively, the patient exhibited no evidence of pain or lameness on the right thoracic limb and radiographs revealed complete healing of the fracture and normal articulation of the scapulohumeral joint. This is the first report of a lesser tubercle fracture associated with a craniolateral shoulder luxation. Surgical intervention resulted in the return of full shoulder joint function in this dog.

Properties of Cartilage Engineered from Elderly Human Chondrocytes for Articular Surface Repair

2012 ◽  
Vol 18 (13-14) ◽  
pp. 1490-1499 ◽  
Author(s):  
Xing Zhao ◽  
David A. Bichara ◽  
Frederick P. Ballyns ◽  
Jeong J. Yoo ◽  
Winnie Ong ◽  
...  
Keyword(s):  
Articular Surface ◽  
Human Chondrocytes ◽  
Surface Repair

Frictional Characteristics and Tissue Loss of Articular Cartilage Under a Novel Wear Regime

2007 ◽  
Author(s):  
Kelly J. Shields ◽  
John R. Owen ◽  
Jennifer S. Wayne
Keyword(s):  
Articular Cartilage ◽  
Articular Surface ◽  
Cartilage Damage ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Tissue Loss ◽  
Joint Function ◽  
Repair Technique ◽  
Repair Techniques

Degenerative joint disease, age, and trauma lead to progressive articular cartilage damage due to the tissue’s limited repair capabilities. Numerous clinical repair techniques with varying degrees of success have been developed in order to repair damaged tissue and restore joint function. One approach is the development of articular cartilage repair tissue to implant into the damaged or diseased articular surface. Determining the viability of an articular repair technique or tissue under in vivo stresses and wear is crucial to predict its success.

Impact of Joint Bleeding on Joint Function in a Murine Model of Hemophilia A.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4041-4041
Author(s):  
Carmen R. Mejia-Carvajal ◽  
Leonard A. Valentino ◽  
Narine Hakobyan ◽  
Tamara Kazarian
Keyword(s):  
Murine Model ◽  
Articular Surface ◽  
Joint Space ◽  
Acute Injury ◽  
Laboratory Animals ◽  
Recurrent Bleeding ◽  
Inflammatory Disorder ◽  
Joint Function ◽  
The Usa ◽  
The Impact

Abstract Hemophilia is a congenital bleeding disorder that commonly results in musculoskeletal complications due to recurrent bleeding into joints. After an acute joint bleed, there is pain, swelling and limited motion due to the increase in intra-articular pressure and inflammation. Blood in the joint space provokes a proliferative and inflammatory disorder known as hemophilic synovitis (HS), which causes mechanical dysfunction and eventually destruction of the articular surface and bone. Among persons in the USA with severe hemophilia, nearly half have some restriction in activity (Evatt 2004) and it is estimated that 73% of boys enter adolescence with arthropathy and between 13–16 years of age, two or more major joints are affected (Brackmann,1992). Detail examination of the earliest changes in joint function following 1–3 joint hemorrhages is difficult to perform in patients. In this project, a murine model of HS (Valentino,2004) was used to examine the impact of a minimum number of hemarthrosis on joint function. The hypothesis tested was that there is a relationship between hemarthrosis and joint dysfunction. It was expected that joint dysfunction would be observed following few bleeds. Also, it was expected that a single hemarthrosis will result in permanent joint dysfunction. To test these hypotheses, 25 mice deficient in factor VIII coagulant activity were injured, times three, at weekly intervals to induce hemarthrosis then their ability to ambulate monitored using a Rotorod: Economex apparatus, which is intended for testing coordination and impairment of locomotor agility of laboratory animals. Mice were trained to ambulate on the rotating rod then injured and retested 2, 4 and 7 days after each hemarthrosis. A 2nd group of 25 mice was not injured and served as controls. At the conclusion of the experiment, mice were sacrificed and the knee joints examined by gross and histological methods. Correlations were drawn between the ambulatory dysfunction and the pathological changes observed. Preliminary data showed: mice can be trained to ambulate on the Rotarod, acute hemarthrosis temporarily impairs their ability to ambulate, and after mice recover from acute injury they regain their lost ability to ambulate to the point that their performance is better than previous.

Chronic Posttraumatic Cartilage Lesion of the Knee Treated With an Acellular Osteochondral-Regenerating Implant: Case History With Rehabilitation Guidelines

2014 ◽  
Vol 23 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Elizaveta Kon ◽  
Matej Drobnic ◽  
Phil A. Davidson ◽  
Andrew Levy ◽  
Ken Zaslav ◽  
...  
Keyword(s):  
Articular Surface ◽  
Cartilage Lesion ◽  
Osteochondral Defects ◽  
Joint Function ◽  
Spontaneous Healing ◽  
Stem Cell Migration ◽  
Acellular Scaffold ◽  
Outerbridge Grade

Osteochondral defects are often symptomatic and lead to deranged joint function. The spontaneous healing capacity of osteochondral defects is limited. In this case study, use of an acellular scaffold capable of induction of mesenchymal stem-cell migration is described. This scaffold was used on an Outerbridge grade IV medical condylar defect measuring ~2 cm2. At 24 mo follow-up, the articular surface appeared restored by MRI, and the patient returned to sports.

Autologous platelets and articular surface repair in an experimental model

2005 ◽  
Vol 10 (2) ◽  
pp. 237-239 ◽  
Author(s):  
Felicito García-Alvarez ◽  
Tomás Castiella ◽  
José María Grasa ◽  
Marta Monzón ◽  
Antonio Laclériga ◽  
...  
Keyword(s):  
Experimental Model ◽  
Articular Surface ◽  
Surface Repair
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