Recurrence Rate in Primary Pterygium Managed by Surgical Excision of Pterygium with Application of Mitomycin-C over Bare Sclera and Free Conjunctival Autografting

2017 ◽  
Vol 3 (3) ◽  
Author(s):  
Devendra Sharma ◽  
Keyword(s):  
Mitomycin C ◽  
Recurrence Rate ◽  
Surgical Excision ◽  
Conjunctival Autografting ◽  
Primary Pterygium

scholarly journals Recurrence Rate of Primary Pterygium Following Excision with Mitomycin C versus Excision with Amniotic Membrane Transplant

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Jawad Humayun ◽  
Mubashir - Rehman ◽  
Mohammad Farhan ◽  
Muhammad Kashif Kamran ◽  
Shahid Abdur Rauf Khan
Keyword(s):  
Mitomycin C ◽  
Recurrence Rate ◽  
Amniotic Membrane ◽  
Surgical Excision ◽  
P Value ◽  
Quasi Experimental ◽  
History Of ◽  
Group A ◽  
The Difference ◽  
Primary Pterygium

Purpose: To compare recurrence rate of primary pterygium following excision with mitomycin c verses excisionwith amniotic membrane transplant.Study Design: Quasi experimental study.Place and Duration of Study: Qazi Hussain Ahmad Medical Complex, Nowshera, from January 2019 to June2019.Material and Methods: One hundred and two patients presenting for the first time with pterygium were includedin the study and were divided into two groups. Patients having conjunctivitis, blephritis, keratitis or any otherocular inflammatory condition and patients having history of chemical burns and symblepharon were excludedfrom the study. Group A underwent surgical excision with 0.02% mitomycin–C application for 3 minutes andGroup B was surgically treated with application of amniotic membrane. Patients of both groups were followed upfor six months to detect recurrence of pterygium. Data was analyzed using SPSS version 20. Frequency andpercentages were calculated for categorical data like age, gender and recurrence rate. Recurrence rate wasstratified among age and sex to see the effect modifiers.Results: Mean age in both groups was 39.98 ± 9.11 years. In group A, 64.70% patients were males and in groupB, 62.74% patients were male. Recurrence of Pterygium was seen in 21.5% patients in group A and 7.84% ingroup B. The difference was statistically significant with a p value of 0.05.Conclusion: Recurrence rate of primary pterygium following excision with mitomycin C is higher than excisionwith amniotic membrane transplant

scholarly journals Characteristics and recurrence of pterygium in Saudi Arabia: a single center study with a long follow‐up

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Waleed Alsarhani ◽  
Saeed Alshahrani ◽  
Mahmood Showail ◽  
Nawaf Alhabdan ◽  
Osama Alsumari ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Recurrence Rate ◽  
Dry Eye ◽  
Amniotic Membrane ◽  
Univariate Analysis ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
First Year ◽  
Conjunctival Autografting

Abstract Background This study described the clinical features of patients with pterygium and analyzed the recurrence rate of conjunctival autografting alone, conjunctival autografting combined with intraoperative mitomycin C, and amniotic membrane grafting. Methods A retrospective cohort study of primary pterygium was conducted between January 2017 and February 2020. Factors associated with pterygium severity and recurrence were analyzed by univariate analysis and logistic regression models. Results The study included 292 patients with an average age of 53.3 ± 14.1 years, while the number of operated cases was 94. Pterygia involving the cornea were observed in 55 % of the cases. The overall rate of recurrence for the three procedures was 17 %. The average time of recurrence was 14.2 ± 11.9 months, with 37 % of the recurrences occurring after the first year. The only factor associated with a significant risk of recurrence was dry eye disease in both univariate (p = 0.021) and multivariate analysis (p = 0.026). The recurrence rates following conjunctival autografting with and without mitomycin C were 15.6 and 15.8 %, respectively. The recurrence rate following the amniotic membrane graft was  twofold (OR= 2.02)  (27 %) that following the conjunctival autograft (15.8 %). Conclusions The only factor associated with the recurrence of pterygium was dry eye disease. More than one-third of recurrences developed after the first year, which stresses the importance of a long follow-up. The recurrence rate in our study following conjunctival graft was slightly higher compared to the literature mainly due to differences in study areas, populations, and follow-up periods.

scholarly journals Preoperative subconjunctival combined injection of bevacizumab and mitomycin C before the surgical excision of primary pterygium: clinical and histological results

2017 ◽  
Vol Volume 11 ◽  
pp. 493-501 ◽  
Author(s):  
Alahmady Hamad Alsmman ◽  
Gamal Abd Ellateif Radwan ◽  
Mortada Ahmed Abozaid ◽  
Usama Ali Mohammed ◽  
Nesreen Gamal Eldein Abd Elhaliem
Keyword(s):  
Mitomycin C ◽  
Surgical Excision ◽  
Histological Results ◽  
Primary Pterygium

scholarly journals Comparing Adjuvant Beta Radiation, Mitomycin C, and Conjunctival Autograft in Primary Pterygium Treatment, a Three-year Follow-up Study

2021 ◽  
Vol 14 (1) ◽  
pp. 82-87
Author(s):  
Khalil M. Al-Salem ◽  
Ahmad T.S. Saif ◽  
Passant S. Saif
Keyword(s):  
Postoperative Complications ◽  
Mitomycin C ◽  
Recurrence Rate ◽  
University Hospital ◽  
Beta Radiation ◽  
Conjunctival Autograft ◽  
Group A ◽  
Pterygium Excision ◽  
Group B ◽  
Primary Pterygium

Purpose: To compare the recurrence rate of primary pterygium surgery after the adjuvant use of Beta radiation, Mitomycin C, and conjunctival autograft. Methods: 180 eyes of 180 patients were included in the study. All cases had primary pterygium excision following the use of adjuvant therapy of Beta radiation or Mitomycin C (0.02% for 5 minutes) or conjunctival autograft. The study was conducted at Fayoum University Hospital, Fayoum, Egypt, and Misr University Hospital. The patients were randomly divided into three groups, with each group comprising 60 patients. Group (A) included patients treated with Beta radiation following Pterygium excision, group (B) patients had primary pterygium excision with the application of 0.02% Mitomycin C for 5 minutes, and group (C) patients had conjunctival autograft to cover the bare area after pterygium excision. Patients were followed up for three years postoperatively. Results: group A had the highest recurrence rate (33.3%) followed by group B (13.3%), and finally group C presented a recurrence rate of 6.7%. Group B showed the highest rate of intra-ocular postoperative complications, while no intra-ocular complications were recorded in group C. Common complications in groups A and B were scleral melting, keratitis, and Dellen formation. Conclusion: Using conjunctival autograft after primary pterygium excision gives the best results regarding the rate of recurrence and postoperative complications. Meanwhile, B-radiation or Mitomycin C did not prove to be as good.

Conjunctival Autografting Combined With Low-Dose Mitomycin C for Prevention of Primary Pterygium Recurrence

2006 ◽  
Vol 141 (6) ◽  
pp. 1044-1050.e2 ◽  
Author(s):  
Joseph Frucht-Pery ◽  
Frederic Raiskup ◽  
Michael Ilsar ◽  
David Landau ◽  
Faik Orucov ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Low Dose ◽  
Conjunctival Autografting ◽  
Primary Pterygium

scholarly journals Comparison of Wide Conjunctival Flap and Conjunctival Autografting Techniques in Pterygium Surgery

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Lokman Aslan ◽  
Murat Aslankurt ◽  
Adnan Aksoy ◽  
Murat Özdemir ◽  
Erdem Yüksel
Keyword(s):  
Inflammatory Cell ◽  
Surgical Excision ◽  
Treatment Method ◽  
Inflammatory Cell Infiltrate ◽  
Conjunctival Flap ◽  
Pterygium Surgery ◽  
Matrix Accumulation ◽  
Time Of Operation ◽  
Conjunctival Autografting ◽  
Primary Pterygium

Pterygium is an abnormal fibrovascular tissue extending on the cornea which is a degenerative and hyperplastic disorder. A stromal overgrowth of fibroblast and blood vessels is accompanied by an inflammatory cell infiltrate and abnormal extracellular matrix accumulation. The surgical excision is the main treatment method of pterygium, but recurrence is the most common postoperative complication. In the present study, we aimed to compare the wide conjunctival flap and the conjunctival autografting techniques in pterygium surgery according to time of operation, safety, and effectiveness. Results showed that the effect of wide conjunctival flap techniques on primary pterygium surgery was found close to the conjunctival autograft techniques. In addition, the flap technique has a shorter surgical time, the surgery does not require extreme experience, feeding of the flap is provided with own vessels since the vascular structure is protected on the upper temporal conjunctival area, reverse placement of the flap is not seen, it needs fewer sutures, so that suture disturbances may reduce, and it is less traumatic than autograft technique during conjunctival transport. Therefore, this technique may be preferred in suitable cases.

scholarly journals Efficacy of sutureless and glue free limbal conjunctival autograft for primary pterygium surgery

2012 ◽  
Vol 4 (2) ◽  
pp. 230-235 ◽  
Author(s):  
K P S Malik ◽  
R Goel ◽  
A Gupta ◽  
S K Gupta ◽  
S Kamal ◽  
...  
Keyword(s):  
Case Series ◽  
Surgical Excision ◽  
Recurrence Rates ◽  
Conjunctival Autograft ◽  
Uncorrected Visual Acuity ◽  
Pterygium Excision ◽  
One Year ◽  
Limbal Conjunctival Autograft ◽  
Conjunctival Autografting ◽  
Primary Pterygium

Introduction: There are numerous adjunctive measures described to reduce the recurrence rates after pterygium excision. Objective: To study the efficacy and complications of sutureless and glue free limbal conjunctival autograft for the management of primary pterygium over a period of one year. Materials and methods: A prospective interventional case series was carried out in 40 consecutive eyes with primary nasal pterygium requiring surgical excision. Pterygium excision with limbal conjunctival autografting without using glue or sutures was performed in all the patients followed by bandaging for 48 hours. The patients were followed up post operatively on 2nd day, 1 week, 6 weeks, 6 months and 12 months. They were examined for haemorrhage, wound gape, graft shrinkage, chemosis, graft dehiscence, recurrence or any other complication. Results: The mean age of the patients was 42.8 years (range 23-61), 75% of which were males. Total graft dehiscence occurred in 2 eyes (5%), graft retraction in 3 eyes (7.5%) and recurrence was seen in 1 eye (2.5%). At 6 weeks postoperatively, the gain in uncorrected visual acuity ranged from 0.18 to 0.5 log MAR in 7 eyes. No other complication was noted. Conclusions: Sutureless and glue free limbal conjunctival autografting following pterygium excision is a safe, effective and economical option for the management of primary pterygium.DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6537 Nepal J Ophthalmol 2012; 4 (2): 230-235

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