scholarly journals ASSESSMENT OF CORRELATION BETWEEN HIV INFECTION AND TUBERCULOSIS WITH MULTIPLE DRUG RESISTANCE

2018 ◽  
Vol 96 (7) ◽  
pp. 25-32 ◽  
Author(s):  
S. А. POPOV ◽  
◽  
T. P. SАBGАYDА ◽  
T. S. RАDINА ◽  
◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hiv Infection ◽  
Multiple Drug Resistance ◽  
Multiple Drug

scholarly journals HIV infection and multiple drug resistant tuberculosis: the frequency of co-infection and treatment efficacy

2021 ◽  
Vol 99 (2) ◽  
pp. 45-51
Author(s):  
O. V. Filinyuk ◽  
A. S. Alliluev ◽  
D. E. Аmichba ◽  
P. N. Golubchikov ◽  
Yu. S. Popelo ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hiv Infection ◽  
Treatment Efficacy ◽  
Multiple Drug Resistance ◽  
Medical Center ◽  
Multiple Drug ◽  
Tuberculosis Patients ◽  
Tomsk Region ◽  
Mdr Tb ◽  
Hiv Negative

The objective of the study: in Tomsk Region, to establish the frequency of multiple drug resistance (MDR) of mycobacterium tuberculosis (MBT) in new tuberculosis patients with the reference to their HIV status and to assess their treatment outcomes.Subjects and methods. The presented results were obtained from a retrospective cohort study of 788 new tuberculosis patients who were registered for MDR TB treatment at Tomsk Phthisiopulmonology Medical Center from January 2017 to April 2019.Results. In Tomsk Region, the level of primary MDR reaches 31.3% in patients with TB/HIV co-infection, while in HIV negative tuberculosis patients, this rate is 24.2%. The incidence of primary MDR/XDR MTB reaches 40% among deceased patients with TB/HIV co-infection. Treatment efficacy in MDR/XDR TB patients with associated HIV infection is low – the effective treatment was achieved only in 7.3% of them. In general (excluding the data on MTB drug resistance and antiretroviral therapy), treatment efficacy of tuberculosis patients with HIV infection is significantly lower versus HIV negative tuberculosis patients: 37.7% and 61.9%, respectively, OR 0.38 [0.28; 0.50], p = 0.001.

Do Multiple Drug Resistance Transporters Interfere with Cell Functioning under Normal Conditions?

2020 ◽  
Vol 85 (12-13) ◽  
pp. 1560-1569
Author(s):  
D. A. Knorre ◽  
K. V. Galkina ◽  
T. Shirokovskikh ◽  
A. Banerjee ◽  
R. Prasad
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug

scholarly journals Amelioration of the Cost of Conjugative Plasmid Carriage in Eschericha coli K12

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 1641-1649
Author(s):  
Cecilia Dahlberg ◽  
Lin Chao
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Conjugative Plasmid ◽  
Energetic Cost ◽  
Multiple Drug ◽  
Genetic Changes ◽  
Batch Cultures ◽  
Transfer Rates ◽  
Bacterial Plasmid ◽  
The Cost

Abstract Although plasmids can provide beneficial functions to their host bacteria, they might confer a physiological or energetic cost. This study examines how natural selection may reduce the cost of carrying conjugative plasmids with drug-resistance markers in the absence of antibiotic selection. We studied two plasmids, R1 and RP4, both of which carry multiple drug resistance genes and were shown to impose an initial fitness cost on Escherichia coli. To determine if and how the cost could be reduced, we subjected plasmid-containing bacteria to 1100 generations of evolution in batch cultures. Analysis of the evolved populations revealed that plasmid loss never occurred, but that the cost was reduced through genetic changes in both the plasmids and the bacteria. Changes in the plasmids were inferred by the demonstration that evolved plasmids no longer imposed a cost on their hosts when transferred to a plasmid-free clone of the ancestral E. coli. Changes in the bacteria were shown by the lowered cost when the ancestral plasmids were introduced into evolved bacteria that had been cured of their (evolved) plasmids. Additionally, changes in the bacteria were inferred because conjugative transfer rates of evolved R1 plasmids were lower in the evolved host than in the ancestral host. Our results suggest that once a conjugative bacterial plasmid has invaded a bacterial population it will remain even if the original selection is discontinued.

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