scholarly journals Pharmacogenetics in anesthesiology: what to look for. Review

2020 ◽  
pp. 63-72
Author(s):  
O. A Makharin ◽  
V. M Genilo ◽  
A. A Bichkov
Keyword(s):  
Calcium Channels ◽  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Opioid Receptor ◽  
Gene Polymorphisms ◽  
Perioperative Period ◽  
Narcotic Analgesics ◽  
Cyp2d6 Polymorphism

Individual pharmacogenetic features of patients areactively studied in various fields of medicine and anesthesiology is no exception. The purpose of this article is to unite the available literature data of polymorphisms affecting the perioperative period. The review includes information obtained from SCOPUS, MedLine, PharmGKB. The effects of cytochrome CYP2D6 polymorphism on the metabolism of tramadol, ondansetron and codeine are described. Also the influence of -opioid receptor OPRM1 polimorphism on the doses of narcotic analgesics and ryanodine receptor RYR1 and calcium channels on the probability of malignant hyperthermia are described, and also considered gene polymorphisms that affect the development of anaphylactic reactions

scholarly journals Genetics of Malignant Hyperthermia

2006 ◽  
Vol 6 ◽  
pp. 1722-1730 ◽  
Author(s):  
Barbara W. Brandom
Keyword(s):  
Malignant Hyperthermia ◽  
Candidate Genes ◽  
Ryanodine Receptor ◽  
Receptor Gene ◽  
Linkage Studies ◽  
Chromosome 19

Study of the genetics of the malignant hyperthermia syndrome began in families in which both malignant hyperthermia (MH) episodes had been experienced and individuals had strongly positive contracture tests diagnostic of susceptibility to MH. Linkage studies associated this MH phenotype to the ryanodine receptor gene (RYR1) at chromosome 19q13.1 in many families. Although the MH phenotype is not always linked to chromosome 19, theRYR1has remained the focus of experimentation. Other candidate genes exist, but few MH-susceptible families have variants of these genes. Hundreds of MH-susceptible people have variants ofRYR1.

scholarly journals Functional Characterization of a Distinct Ryanodine Receptor Mutation in Human Malignant Hyperthermia-susceptible Muscle

1997 ◽  
Vol 272 (8) ◽  
pp. 5256-5260 ◽  
Author(s):  
Michael Richter ◽  
Lothar Schleithoff ◽  
Thomas Deufel ◽  
Frank Lehmann-Horn ◽  
Annegret Herrmann-Frank
Keyword(s):  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Functional Characterization ◽  
Malignant Hyperthermia Susceptible

Additional evidence that the ryanodine receptor gene (RYR1) causes malignant hyperthermia and severe skeletal malformations

2012 ◽  
Vol 161 (1) ◽  
pp. 234-235
Author(s):  
Yosuke Kakisaka ◽  
Kazuhiro Haginoya ◽  
Yuko Takahashi ◽  
Tatsuhiro Ochiai ◽  
Ikuma Fujiwara ◽  
...  
Keyword(s):  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Receptor Gene ◽  
Skeletal Malformations

Molecular Genetic Analysis of the Ryanodine Receptor Gene (RYR1) in Korean Malignant Hyperthermia Families

2010 ◽  
Vol 30 (6) ◽  
pp. 702-710 ◽  
Author(s):  
Ho Lee ◽  
Dong Chan Kim ◽  
Jae Hyeon Lee ◽  
Yong Gon Cho ◽  
Hye Soo Lee ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Receptor Gene ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis

scholarly journals Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology and Target Identification of Thio-wurtzine, a Potent Inhibitor of the Opioid Receptors and the Voltage-Dependent Calcium Channels

2021 ◽  
Author(s):  
Stephanie Aguero ◽  
Simon Megy ◽  
Raphael Terreux ◽  
Mailys Fournier ◽  
Daria Kulagina ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Opioid Receptors ◽  
Mechanism Of Action ◽  
Pain Treatment ◽  
Target Identification ◽  
Animal Experiments ◽  
Complex Mechanism ◽  
Narcotic Analgesics ◽  
Voltage Dependent

The number of candidate molecules for new non-narcotic analgesics is extremely limited. Here we report the identification of thiowurtzine, a new potent analgesic molecule with promising application in chronic pain treatment. We describe the chemical synthesis of this unique compound derived from the hexaazaisowurtzitane (CL-20) explosive molecule. Then we use animal experiments to assess its analgesic activity in vivo upon chemical, thermal and mechanical exposures, compared to the effect of several reference drugs. Finally, we investigate the potential receptors of thiowurtzine in order to better understand its complex mechanism of action. We use docking, molecular modeling and molecular dynamics simula-tions to identify and characterize the potential targets of the drug and confirm the results of the animal experiments. Our findings finally indicate that thiowurtzine may have a complex mechanism of action, by targeting the mu, kappa, delta and ORL1 opioid receptors, and the voltage-gated calcium channels as well.

scholarly journals Genotype and phenotype relationships for mutations in the ryanodine receptor in patients referred for diagnosis of malignant hyperthermia

1995 ◽  
Vol 75 (3) ◽  
pp. 307-310 ◽  
Author(s):  
J E Fletcher ◽  
L Tripolitis ◽  
M Hubert ◽  
G M Vita ◽  
R C Levitt ◽  
...  
Keyword(s):  
Malignant Hyperthermia ◽  
Ryanodine Receptor
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