Deep Neural Networks Identify Signaling Mechanisms of ErbB-Family Drug Resistance From a Continuous Cell Morphology State Space

2018 ◽  
Author(s):  
James Longden ◽  
Xavier Robin ◽  
Mathias Engel ◽  
Jesper Ferkinghoff- Borg ◽  
Ida Kjaer ◽  
...  
Cell Reports ◽  
2021 ◽  
Vol 34 (3) ◽  
pp. 108657
Author(s):  
James Longden ◽  
Xavier Robin ◽  
Mathias Engel ◽  
Jesper Ferkinghoff-Borg ◽  
Ida Kjær ◽  
...  

2019 ◽  
Vol 31 (3) ◽  
pp. 538-554
Author(s):  
Michael Hauser ◽  
Sean Gunn ◽  
Samer Saab ◽  
Asok Ray

This letter deals with neural networks as dynamical systems governed by finite difference equations. It shows that the introduction of [Formula: see text]-many skip connections into network architectures, such as residual networks and additive dense networks, defines [Formula: see text]th order dynamical equations on the layer-wise transformations. Closed-form solutions for the state-space representations of general [Formula: see text]th order additive dense networks, where the concatenation operation is replaced by addition, as well as [Formula: see text]th order smooth networks, are found. The developed provision endows deep neural networks with an algebraic structure. Furthermore, it is shown that imposing [Formula: see text]th order smoothness on network architectures with [Formula: see text]-many nodes per layer increases the state-space dimension by a multiple of [Formula: see text], and so the effective embedding dimension of the data manifold by the neural network is [Formula: see text]-many dimensions. It follows that network architectures of these types reduce the number of parameters needed to maintain the same embedding dimension by a factor of [Formula: see text] when compared to an equivalent first-order, residual network. Numerical simulations and experiments on CIFAR10, SVHN, and MNIST have been conducted to help understand the developed theory and efficacy of the proposed concepts.


Author(s):  
Alex Hernández-García ◽  
Johannes Mehrer ◽  
Nikolaus Kriegeskorte ◽  
Peter König ◽  
Tim C. Kietzmann

2018 ◽  
Author(s):  
Chi Zhang ◽  
Xiaohan Duan ◽  
Ruyuan Zhang ◽  
Li Tong

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