The Interleukin-6/Signal Transducer and Activator of Transcription 3/Snail Pathway Mediates Epithelial-Mesenchymal Transition in Recurrent Liver Cancer after Radiofrequency Ablation

2018 ◽  
Author(s):  
Yuliang Li ◽  
Tong Zhou ◽  
Chuanxin Wang ◽  
Yongzheng Wang ◽  
Bin Liu ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Cancer ◽  
Interleukin 6 ◽  
Epithelial Mesenchymal Transition ◽  
Signal Transducer ◽  
Mesenchymal Transition ◽  
Transcription 3

scholarly journals A mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)

2013 ◽  
Vol 455 (2) ◽  
pp. 229-237 ◽  
Author(s):  
Christer Hogstrand ◽  
Peter Kille ◽  
Margaret Leigh Ackland ◽  
Stephen Hiscox ◽  
Kathryn M. Taylor
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Cell Detachment ◽  
Signal Transducer ◽  
Anoikis Resistance ◽  
Mesenchymal Transition ◽  
Cancer Spread ◽  
And Migration ◽  
Cellular Zinc ◽  
Transcription 3

We demonstrate a novel mechanism for the ability of cellular zinc to drive cell detachment and migration with implications for breast cancer spread. This mechanism involves a zinc uptake channel ZIP6 (also known as SLC39A6) and a transcription factor, STAT3.

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