Inferior Vena Cava Size Predicts the Diuretic Response in Acute Decompensated Heart Failure Patients with Severe Aortic Stenosis: Sub-Analysis of the LOHAS Registry

2022 ◽  
Author(s):  
Takuma Takada ◽  
Kentaro Jujo ◽  
Takuro Abe ◽  
Kensuke Shimazaki ◽  
Yugo Nara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Stenosis ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Severe Aortic Stenosis ◽  
Vena Cava ◽  
Decompensated Heart Failure ◽  
Heart Failure Patients ◽  
Diuretic Response

Short-term effects of low-dose tolvaptan in acute decompensated heart failure patients with severe aortic stenosis: the LOHAS registry

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Y Watanabe ◽  
Y Nara ◽  
H Hioki ◽  
H Kawashima ◽  
A Kataoka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Stenosis ◽  
Low Dose ◽  
Acute Decompensated Heart Failure ◽  
Severe Aortic Stenosis ◽  
Decompensated Heart Failure ◽  
Funding Source ◽  
Short Term ◽  
Heart Failure Patients ◽  
Short Term Effects

Abstract Background Tolvaptan exerts potent diuretic effects in heart failure patients without hemodynamic instability. Nonetheless, its clinical efficacy for acute decompensated heart failure (ADHF) due to severe aortic stenosis (AS) remains unclear. This study aimed to evaluate the short-term effects of tolvaptan in ADHF patients with severe AS. Methods The LOw-Dose Tolvaptan (7.5 mg) in Decompensated Heart Failure Patients with Severe Aortic Stenosis (LOHAS) registry is a multicenter (7 centers) prospective registry that assessed the short-term effects of tolvaptan in subjects hospitalized for ADHF with severe AS. A total of 59 subjects were enrolled between September 2014 and December 2017. The primary endpoints were changes in body weight and fluid balance measured daily from baseline up to 4 days. Results The median [interquartile range] patient age and aortic valve area were 85.0 [81.0–89.0] years and 0.58 [0.42–0.74] cm2, respectively. Body weight continuously decreased, and fluid balance was maintained from baseline to day 4 (p<0.001, p=0.194, respectively). Median serum B-type natriuretic peptide concentration significantly decreased from 910.5 to 740.0 pg/mL by day 4 (p=0.002). However, systolic blood pressure and heart rate were non-significantly changed (p=0.250, p=0.656, respectively). Hypernatremia (>150 mEq/L) and worsening renal function occurred in 2 (3.4%) and 4 (6.8%) patients, respectively. Conclusions Short-term treatment with low-dose tolvaptan is safe and effective, providing stable hemodynamic parameters in patients with ADHF and severe AS. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): This research was supported by Otsuka Pharmaceutical Co., Ltd.

Inferior vena cava diameter change after intravenous furosemide in patients diagnosed with acute decompensated heart failure

2014 ◽  
Vol 43 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Stefan Tchernodrinski ◽  
Brian P. Lucas ◽  
Ambarish Athavale ◽  
Carolina Candotti ◽  
Bosko Margeta ◽  
...  
Keyword(s):  
Heart Failure ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Decompensated Heart Failure ◽  
Inferior Vena Cava Diameter ◽  
Diameter Change

Abstract 13532: Comparison of Inferior Vena Cava and Subclavian Vein Collapsibility Index by Ultrasound for Determination of Relative Intravascular Volume in Acute Decompensated Heart Failure

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Yvonne E Kaptein ◽  
Pedro D Salinas ◽  
Payal Sharma ◽  
Ana Christina Perez Moreno ◽  
Nasir Sulemanjee ◽  
...  
Keyword(s):  
Heart Failure ◽  
Inferior Vena Cava ◽  
Subclavian Vein ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Decompensated Heart Failure ◽  
Right Atrial ◽  
Intravascular Volume ◽  
Collapsibility Index

Introduction: Accurate assessment of relative intravascular volume is needed to guide management of acute decompensated heart failure (ADHF). Current assessments include history and physical examination (specific but not sensitive), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (sensitive but not specific).Ultrasound (US) of inferior vena cava (IVC) collapsibility with respiration is commonly used to assess intravascular volume and right atrial pressure (RAP) but may be technically challenging. US of subclavian vein (SCV) collapsibility may provide an alternative assessment. Hypothesis: In ADHF, SCV collapsibility index (CI) may correlate with IVC CI and RAP. Methods: Prospective study of non-ventilated patients with ADHF who had NT-proBNP within 24 hours of paired IVC and SCV diameter measurements by US. Results: Forty-two patients (median age 66.5 years, 45% female, and 64% white) were enrolled, with 52 encounters. Cardiovascular comorbidities included hypertension (93%), chronic kidney disease (64%), coronary artery disease (55%), atrial fibrillation/flutter (55%), and valvular disease (55%). Of 38 patients with known heart failure, 63% had HFrEF, 16% HFmrEF, and 21% HFpEF.Correlation of paired IVC CI and SCV CI with relaxed breathing was R = 0.65 (N = 36). Correlation of paired IVC CI and SCV CI with forced inhalation was R = 0.47 (N = 36). Log 10 NT-proBNP was inversely correlated with IVC CI (R = -0.35; N = 51) and SCV CI (R = -0.33; N = 36). For patients with right heart catheterization within 24 hours of US, correlation of RAP to IVC CI was R = -0.53 (N = 9), and RAP to SCV CI was R = -0.65 (N = 9). Moderate or severe tricuspid regurgitation decreased CI independently of intravascular volume and RAP (figure). Conclusions: US measurements of SCV CI correlate well with paired IVC CI in non-ventilated ADHF. RAP by RHC correlated better with SCV CI than with IVC CI. SCV CI may be a reliable alternative to IVC CI in assessing relative intravascular volume.

scholarly journals Short-term effects of low-dose tolvaptan in acute decompensated heart failure patients with severe aortic stenosis: The LOHAS registry

2020 ◽  
Vol 305 ◽  
pp. 82-86
Author(s):  
Yusuke Watanabe ◽  
Yugo Nara ◽  
Hirofumi Hioki ◽  
Hideyuki Kawashima ◽  
Akihisa Kataoka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Aortic Stenosis ◽  
Low Dose ◽  
Acute Decompensated Heart Failure ◽  
Severe Aortic Stenosis ◽  
Decompensated Heart Failure ◽  
Short Term ◽  
Heart Failure Patients ◽  
Short Term Effects

The value of the inferior vena cava ultrasound in the decision to hospitalise in patients with acute decompensated heart failure; the best sonographic measurement method?

2020 ◽  
pp. 1-13
Author(s):  
Adnan Yamanoglu ◽  
Nalan Gokce Celebi Yamanoglu ◽  
Semi Ozturk ◽  
Sumeyye Cakmak ◽  
Serhat Akay ◽  
...  
Keyword(s):  
Heart Failure ◽  
Inferior Vena Cava ◽  
Measurement Method ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Decompensated Heart Failure

scholarly journals Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the CAVA‐ADHF‐DZHK10 trial

2020 ◽  
Vol 7 (3) ◽  
pp. 973-983
Author(s):  
Alexander Jobs ◽  
Reinhard Vonthein ◽  
Inke R. König ◽  
Jane Schäfer ◽  
Matthias Nauck ◽  
...  
Keyword(s):  
Heart Failure ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Decompensated Heart Failure ◽  
Design Rationale

scholarly journals Admission inferior vena cava measurements are associated with mortality after hospitalization for acute decompensated heart failure

2016 ◽  
Vol 11 (11) ◽  
pp. 778-784 ◽  
Author(s):  
Pilar Cubo-Romano ◽  
Juan Torres-Macho ◽  
Nilam J. Soni ◽  
Luis F. Reyes ◽  
Ana Rodríguez-Almodóvar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Decompensated Heart Failure

scholarly journals MP295RESPIRATORY VARIATION OF INFERIOR VENA CAVA DIAMETER AND ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii534-iii535
Author(s):  
Ekaterina Makeeva ◽  
Elena Efremova ◽  
Alexander Shutov ◽  
Maksim Menzorov
Keyword(s):  
Heart Failure ◽  
Acute Kidney Injury ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Acute Decompensated Heart Failure ◽  
Vena Cava ◽  
Kidney Injury ◽  
Decompensated Heart Failure ◽  
Inferior Vena Cava Diameter
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