scholarly journals Clinical Utility Of The Exhaled Nitric Oxide (NO) Measurement With Portable Devices In The Management Of Allergic Airway Inflammation And Asthma

2019 ◽  
Vol Volume 12 ◽  
pp. 331-341 ◽  
Author(s):  
S Duong-Quy
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Clinical Utility ◽  
Allergic Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Portable Devices

Exhaled nitric oxide estimation by a simple and efficient noninvasive technique and its utility as a marker of airway inflammation in mice

2009 ◽  
Vol 107 (1) ◽  
pp. 295-301 ◽  
Author(s):  
Tanveer Ahmad ◽  
Ulaganathan Mabalirajan ◽  
Duraisamy Arul Joseph ◽  
Lokesh Makhija ◽  
Vijay Pal Singh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Airway Remodeling ◽  
Allergen Challenge ◽  
Allergic Airway Inflammation ◽  
Ambient Air ◽  
Exhaled Nitric Oxide ◽  
Noninvasive Technique ◽  
Modified Method ◽  
Chronic Models

Allergic airway inflammation (AI) is commonly associated with enhanced exhaled nitric oxide (ENO) in both humans and mice. Since mouse models are being used to understand various mechanisms of asthma, a noninvasive, simple, and reproducible method to determine ENO in mice is required for serial nonterminal assessment that can be used independent of environmental situations in which the ambient air contains substantial amounts of NO as a contaminant. The aim of this study was to noninvasively measure ENO in individual mice and to test its utility as a marker of AI in different models of allergic AI. We modified the existing ENO measuring methods by incorporating flushing and washout steps that allowed simple but reliable measurements under highly variable ambient NO conditions (1–100 ppb). This method was used to serially follow ENO in acute and chronic models of allergic AI in mice. ENO was reproducibly measured by this modified method and was positively correlated to AI in both acute and chronic models of asthma but was not independently related to airway remodeling. Resolution of AI and other related parameters in dexamethasone-treated mice resulted in reduction of ENO, further confirming this association. Restriction of allergen challenge to pulmonary but not nasal airways was associated with a smaller increase in ENO compared with allergen challenge to both. Hence, ENO can now be reliably measured in mice independent of ambient NO levels and is a valid biomarker for AI. However, nasal and pulmonary airways are likely to be independent sources of ENO, and any results must be interpreted as such.

Off-Line Fractional Exhaled Nitric Oxide Measurement Is Useful to Screen Allergic Airway Inflammation in an Adult Population

2007 ◽  
Vol 44 (10) ◽  
pp. 805-810 ◽  
Author(s):  
Junpei Saito ◽  
Suguru Sato ◽  
Hideki Hasunuma ◽  
Yasushi Ishimaru ◽  
Hiroshi Kanegae ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Adult Population ◽  
Allergic Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD

Lung ◽  
2014 ◽  
Vol 192 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Kun-Ta Chou ◽  
Kang-Cheng Su ◽  
Shiang-Fen Huang ◽  
Yi-Han Hsiao ◽  
Ching-Min Tseng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide

The effect of omalizumab on small airway inflammation as measured by exhaled nitric oxide in moderate-to-severe asthmatic patients

2014 ◽  
Vol 35 (3) ◽  
pp. 241-249 ◽  
Author(s):  
M. Asghar Pasha ◽  
David Jourd'heuil ◽  
Francis Jourd'heuil ◽  
Lori Mahon ◽  
Francisco Romero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Asthmatic Patients ◽  
Severe Asthmatic

Fraction of Exhaled Nitric Oxide Levels Are Elevated in People Living With Human Immunodeficiency Virus Compared to Uninfected Controls, Suggesting Increased Eosinophilic Airway Inflammation

2020 ◽  
Author(s):  
Rebekka F Thudium ◽  
Nicolai L P Hughes ◽  
Shoaib Afzal ◽  
Yunus Çolak ◽  
Marco Gelpi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Human Immunodeficiency Virus ◽  
Airway Inflammation ◽  
Immunoglobulin E ◽  
Exhaled Nitric Oxide ◽  
Airflow Limitation ◽  
Hiv Status ◽  
General Population Study ◽  
Increased Risk ◽  
Immunodeficiency Virus

Abstract Background Increased risk of asthma and chronic obstructive pulmonary disease has been reported in people living with human immunodeficiency virus (PLWH). Fraction of exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation. We assessed FeNO levels in PLWH and matched uninfected controls and investigated whether human immunodeficiency virus (HIV) status is independently associated with elevated FeNO. Methods FeNO was quantified by NIOX Vero and pulmonary function was assessed by spirometry in 432 PLWH from the Copenhagen Comorbidity in HIV Infection Study and in 1618 age- and sex-matched uninfected controls from the Copenhagen General Population Study. Elevated FeNO was defined as ≥25 parts per billion. Associations between FeNO and HIV status were adjusted for known potential confounders. Results Mean age of PLWH was 50.7 (standard deviation [SD], 11.1) years and 97.4% received combination antiretroviral therapy. PLWH had higher FeNO than uninfected controls (median, 17.0 [interquartile range {IQR}, 11.0–26.0] vs 13.0 [IQR, 9.0–19.0]; P < .001). Also, PLWH had a higher prevalence of elevated FeNO than uninfected controls (27.5% vs 12.3%; P < .001). This association remained after adjusting for age, sex, height, smoking status, use of airway medication, blood eosinophils, and immunoglobulin E (adjusted OR [aOR], 3.56 [95% CI, 2.51–5.04]; P < .001). Elevated FeNO was associated with self-reported asthma (aOR, 2.65 [95% CI, 1.66–4.24]; P < .001) but not with airflow limitation (aOR, 1.07 [95% CI, .71–1.62]; P = .745). Conclusions HIV status was independently associated with elevated FeNO, suggesting increased eosinophilic airway inflammation. The potential impact on chronic lung disease pathogenesis needs further investigation.

scholarly journals Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period

2020 ◽  
Vol 56 (1) ◽  
pp. 2000011
Author(s):  
Erika Garcia ◽  
Yue Zhang ◽  
Edward B. Rappaport ◽  
Kiros Berhane ◽  
Patrick Muchmore ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Clinical Care ◽  
Somatic Growth ◽  
Allergic Airway Inflammation ◽  
Population Based ◽  
Exhaled Nitric Oxide ◽  
Childhood And Adolescence ◽  
Additive Mixed Models ◽  
Healthy Participants ◽  
Hispanic White

Fractional exhaled nitric oxide (FENO50), a marker of allergic airway inflammation, is used in respiratory research and asthma clinical care; however, its trajectory with increasing age during childhood has not been well characterised. We examined FENO50 longitudinally during a period of important somatic growth to describe trajectories across childhood and adolescence in healthy participants and evaluate clinical factors as potential determinants of trajectories.FENO50 was collected at six visits over 8 years in a population-based cohort of 1791 schoolchildren without asthma (median age at entry 8.4 years). Smooth sex-specific FENO50 trajectories were estimated using generalised additive mixed models, with participant-level random effects. We evaluated whether sex-specific trajectories were influenced by race/ethnicity, body mass index (BMI) percentile, allergic rhinitis or puberty.Different FENO50 patterns were observed by sex in later childhood and several factors were associated with either FENO50 level or change in FENO50 as participants aged. FENO50–age trajectories were similar by sex until age ∼11.5 years, after which males had greater FENO50 change than females. This divergence in FENO50–age trajectories coincides with puberty. Males with higher starting BMI percentile had attenuated FENO50–age slopes. Among males, FENO50 levels were lower in non-Hispanic white subjects. Among both sexes, participants with rhinitis had higher FENO50. FENO50 levels within individuals tracked over time; however, there was considerable variation in FENO50 patterns across participants.FENO50 trajectories from longitudinal data provide evidence of sex differences coinciding with puberty, suggesting potential hormone link. Improved understanding of determinants of FENO50 trajectories is needed to realise the potential for using individualised predicted FENO50 trajectories.

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