ambient air
Recently Published Documents


TOTAL DOCUMENTS

10484
(FIVE YEARS 4676)

H-INDEX

131
(FIVE YEARS 48)

2022 ◽  
Vol 227 ◽  
pp. 107111
Author(s):  
A.Ya. Pak ◽  
K.B. Larionov ◽  
E.N. Kolobova ◽  
K.V. Slyusarskiy ◽  
J. Bolatova ◽  
...  

2022 ◽  
Vol 204 ◽  
pp. 112065
Author(s):  
Si-Tian Zang ◽  
Jie Luan ◽  
Ling Li ◽  
Hui-Xin Yu ◽  
Qi-Jun Wu ◽  
...  

Author(s):  
Andrew Fu Wah Ho ◽  
Mervyn Jun Rui Lim ◽  
Huili Zheng ◽  
Aloysius Sheng-Ting Leow ◽  
Benjamin Yong-Qiang Tan ◽  
...  

2022 ◽  
Vol 204 ◽  
pp. 111975
Author(s):  
Toyib Olaniyan ◽  
Lauren Pinault ◽  
Chi Li ◽  
Aaron van Donkelaar ◽  
Jun Meng ◽  
...  

2022 ◽  
Vol 148 ◽  
pp. 107757
Author(s):  
V. Zinnecker ◽  
S. Madden ◽  
C. Stokes-Griffin ◽  
P. Compston ◽  
A.V. Rode ◽  
...  

2022 ◽  
Vol 806 ◽  
pp. 150298
Author(s):  
David J.X. Gonzalez ◽  
Christina K. Francis ◽  
Gary M. Shaw ◽  
Mark R. Cullen ◽  
Michael Baiocchi ◽  
...  

2022 ◽  
Vol 23 (2) ◽  
pp. 889
Author(s):  
Atsuya Matsui ◽  
Jean-Pierre Bellier ◽  
Takeshi Kanai ◽  
Hiroki Satooka ◽  
Akio Nakanishi ◽  
...  

The most common type of dementia, Alzheimer’s disease, is associated with senile plaques formed by the filamentous aggregation of hydrophobic amyloid-β (Aβ) in the brains of patients. Small oligomeric assemblies also occur and drugs and chemical compounds that can interact with such assemblies have attracted much attention. However, these compounds need to be solubilized in appropriate solvents, such as ethanol, which may also destabilize their protein structures. As the impact of ethanol on oligomeric Aβ assembly is unknown, we investigated the effect of various concentrations of ethanol (0 to 7.2 M) on Aβ pentameric assemblies (Aβp) by combining blue native-PAGE (BN-PAGE) and ambient air atomic force microscopy (AFM). This approach was proven to be very convenient and reliable for the quantitative analysis of Aβ assembly. The Gaussian analysis of the height histogram obtained from the AFM images was correlated with band intensity on BN-PAGE for the quantitative estimation of Aβp. Our observations indicated up to 1.4 M (8.3%) of added ethanol can be used as a solvent/vehicle without quantitatively affecting Aβ pentamer stability. Higher concentration induced significant destabilization of Aβp and eventually resulted in the complete disassembly of Aβp.


Sign in / Sign up

Export Citation Format

Share Document