scholarly journals IgE-Mediated Systemic Anaphylaxis And Its Association With Gene Polymorphisms Of ACE, Angiotensinogen And Chymase

2019 ◽  
Vol Volume 12 ◽  
pp. 343-361 ◽  
Author(s):  
Veronica A Varney ◽  
Alex Nicholas ◽  
Amena Warner ◽  
Nazira Sumar
Keyword(s):  
Gene Polymorphisms ◽  
Systemic Anaphylaxis ◽  
Ige Mediated

scholarly journals IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling

2011 ◽  
Vol 127 (3) ◽  
pp. 795-805.e6 ◽  
Author(s):  
Clinton B. Mathias ◽  
Suejy A. Hobson ◽  
Maria Garcia-Lloret ◽  
Greg Lawson ◽  
Dimitri Poddighe ◽  
...  
Keyword(s):  
Receptor Signaling ◽  
Systemic Anaphylaxis ◽  
Food Antigens ◽  
Ige Mediated

scholarly journals S1P4 Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells

2018 ◽  
Vol 19 (5) ◽  
pp. 1279 ◽  
Author(s):  
Joseph Kulinski ◽  
Richard Proia ◽  
Elisabeth Larson ◽  
Dean Metcalfe ◽  
Ana Olivera
Keyword(s):  
Mast Cells ◽  
Systemic Anaphylaxis ◽  
Ige Mediated ◽  
Passive Systemic Anaphylaxis

scholarly journals Platelet Activation is Increased in IgE-mediated Systemic Anaphylaxis but not in IgE-mediated Oral Antigen-induced Anaphylaxis in Mice

2018 ◽  
Vol 141 (2) ◽  
pp. AB192
Author(s):  
Andrew T. Dang ◽  
Yanfen Yang ◽  
Lisa Waggoner ◽  
Amnah Yamani ◽  
Taeko Noah ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Systemic Anaphylaxis ◽  
Ige Mediated

Enhanced IL-4 Receptor Signaling Promotes IgE-mediated Systemic Anaphylaxis and Impaired Tolerance to Food Antigens

2011 ◽  
Vol 127 (2) ◽  
pp. AB245-AB245
Author(s):  
C.B. Mathias ◽  
S.A. Hobson ◽  
M. Garcia-Lloret ◽  
G. Lawson ◽  
D. Poddighe ◽  
...  
Keyword(s):  
Receptor Signaling ◽  
Systemic Anaphylaxis ◽  
Food Antigens ◽  
Ige Mediated

scholarly journals Basophils play a pivotal role in IgG‐ but not IgE‐mediated systemic anaphylaxis in contrast to mast cells

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Hajime Karasuyama ◽  
Yusuke Tsujimura ◽  
Kazushige Obata ◽  
Kaori Mukai ◽  
Hideto Nishikado ◽  
...  
Keyword(s):  
Mast Cells ◽  
Pivotal Role ◽  
Systemic Anaphylaxis ◽  
Ige Mediated

scholarly journals Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

1999 ◽  
Vol 189 (10) ◽  
pp. 1573-1579 ◽  
Author(s):  
Azusa Ujike ◽  
Yoko Ishikawa ◽  
Masao Ono ◽  
Takae Yuasa ◽  
Tadashi Yoshino ◽  
...  
Keyword(s):  
Fc Receptors ◽  
Immediate Hypersensitivity ◽  
Effector Cells ◽  
Systemic Anaphylaxis ◽  
Proinflammatory Mediators ◽  
High Affinity Receptor ◽  
Ige Mediated ◽  
Affinity Receptor ◽  
Deficient Mice

It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, FcεRI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, FcγRII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in FcγR-deficient mice. Mice deficient in the inhibitory receptor for IgG, FcγRIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, FcγRIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, FcγRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.

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