scholarly journals A patient with Korsakoff syndrome of psychiatric and alcoholic etiology presenting as DSM-5 mild neurocognitive disorder

2019 ◽  
Vol Volume 15 ◽  
pp. 1311-1320
Author(s):  
Georgios Nikolakaros ◽  
Timo Kurki ◽  
Arttu Myllymäki ◽  
Tuula Ilonen
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sarah E. Pape ◽  
Tamara al Janabi ◽  
Nicholas J. Ashton ◽  
Abdul Hye ◽  
Rory Sheehan ◽  
...  

AbstractThe validity of dementia diagnostic criteria depends on their ability to distinguish dementia symptoms from pre-existing cognitive impairments. The study aimed to assess inter-rater reliability and concurrent validity of DSM-5 criteria for neurocognitive disorder in Down syndrome. The utility of mild neurocognitive disorder as a distinct diagnostic category, and the association between clinical symptoms and neurodegenerative changes represented by the plasma biomarker neurofilament light were also examined. 165 adults with Down syndrome were included. Two clinicians independently applied clinical judgement, DSM-IV, ICD-10 and DSM-5 criteria for dementia (or neurocognitive disorder) to each case. Inter-rater reliability and concurrent validity were analysed using the kappa statistic. Plasma neurofilament light concentrations were measured for 55 participants as a marker of neurodegeneration and between group comparisons calculated. All diagnostic criteria showed good inter-rater reliability apart from mild neurocognitive disorder which was moderate (k = 0.494). DSM- 5 criteria had substantial concurrence with clinical judgement (k = 0.855). When compared to the no neurocognitive disorder group, average neurofilament light concentrations were higher in both the mild and major neurocognitive disorder groups. DSM-5 neurocognitive disorder criteria can be used reliably in a Down syndrome population and has higher concurrence with clinical judgement than the older DSM-IV and ICD-10 criteria. Whilst the inter-rater reliability of the mild neurocognitive disorder criteria was modest, it does appear to identify people in an early stage of dementia with underlying neurodegenerative changes, represented by higher average NfL levels.


2017 ◽  
Vol 25 (4) ◽  
pp. 328-339 ◽  
Author(s):  
Tobias Luck ◽  
Francisca S. Then ◽  
Matthias L. Schroeter ◽  
Veronica Witte ◽  
Christoph Engel ◽  
...  

2006 ◽  
Vol 14 (7S_Part_4) ◽  
pp. P237-P238
Author(s):  
Alexandra Polcher ◽  
Steffen Wolfsgruber ◽  
Oliver Peters ◽  
Lutz Frölich ◽  
Jens Wiltfang ◽  
...  

2017 ◽  
pp. 149
Author(s):  
Charles Ysaacc Da Silva Rodrigues ◽  
Paula Carvalho Figueiredo ◽  
Hidekel Quino Montes ◽  
Marta Gruart Vila

Objetivo: Identificar el nivel de relación entre la depresión y las funciones cognitivas del enfermo de Alzheimer en fase inicial. Cuadro teórico: La depresión es factor de riesgo para las demencias y consecuentemente para la enfermedad de Alzheimer (EA), debido a la pérdida de memoria, que tiende a asociarse con dificultades de orientación, de aprendizaje y reconocimiento. Metodología: Participaron en esta investigación un total de 142 adultos mayores divididos en dos grupos, con y sin diagnóstico clínico de Alzheimer y depresión. Los participantes fueron evaluados a través de la aplicación del Inventario de Depresión de Beck II (BDI-II), y el Mini Mental (MME) de Folstein. Resultados: Se encontraron efectos estadísticamente significativos entre cognición y depresión en adultos mayores con EA, en fase inicial. Conclusiones: Se concluye que existe una alta posibilidad de cambios cognoscitivos del enfermo con Alzheimer, cuando su enfermedad se encuentra asociada a la depresión. Además, los resultados apuntan a la cognición como factor responsable de las alteraciones conductuales del enfermo, como consecuencia del empeoramiento de la depresión.  


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