scholarly journals Propylthiouracil-induced liver failure and artificial liver support systems: a case report and review of the literature

2017 ◽  
Vol Volume 13 ◽  
pp. 65-68 ◽  
Author(s):  
Dongbo Wu ◽  
Enqiang Chen ◽  
Lang Bai ◽  
Hong Tang
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Support Systems ◽  
Artificial Liver ◽  
Review Of The Literature ◽  
Liver Support ◽  
Artificial Liver Support

scholarly journals Serum Lactate: Creatinine Ratio as a Prognostic Marker for Liver Failure Patients Treated by artificial liver support systems

2020 ◽  
Author(s):  
Shuilin Sun ◽  
Ling Chen ◽  
Guanlin Zhou ◽  
Lili Guo ◽  
Yunquan Cai ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support Systems ◽  
Cohort Analysis ◽  
Proton Nuclear Magnetic Resonance ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Time Activity ◽  
Middle Stage ◽  
Death Group

Abstract Background: To screen potential serum prognostic markers for patients with liver failure treated by artificial liver support systems (ALSSs).Methods: Serum samples were obtained from 57 liver-failure patients before and after ALSSs therapy and analyzed by proton nuclear magnetic resonance. The diagnostic values were evaluated by calculation of the area under a receiver-operating characteristic curve (AUROC). Two retrospective analyses were further employed.Results: Metabonomics analysis showed that ratios of creatine:creatinine, taurine:creatinine, and lactate:creatinine were significantly altered and restored to normal levels after ALSSs treatment. The ratio of lactate:creatinine showed the highest AUROC value (0.650), which was higher than that of the prothrombin time activity (PTA, 0.562). A total of 105 cases of retrospective analysis showed that serum lactate:creatinine ratios among the liver-failure patients were 0.038 ± 0.002 (survival group, n=48), 0.048 ± 0.005 (three-month death group, n=24), and 0.052 ± 0.005 (one-month death group, n=33), which was significantly negatively correlated with survival (r= - 0.26). Another retrospective cohort analysis (n=81) of the early to middle stage liver-failure patients treated by ALSSs showed that the AUROC of the lactate:creatinine ratio for diagnosis of those who survived for one subsequent month was 0.827, which was higher than that of PTA (0.628) and lactate (0.765).Conclusion: The serum lactate:creatinine ratio may be a more sensitive measure than either the PTA or the lactate to evaluate the prognosis of ALSSs treatment in early to middle stage of liver-failure patients. This finding is worthy of further study in clinical applications.

Extracorporeal Artificial Liver Support Systems

2010 ◽  
pp. 501-519 ◽  
Author(s):  
Rafael Bañares ◽  
María-Vega Catalina
Keyword(s):  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

scholarly journals Efficacy of a Larger Version of the Hybrid Artificial Liver Support System Using a Polyurethane Foam/Spheroid Packed-Bed Module in a Warm Ischemic Liver Failure Pig Model for Preclinical Experiments

2003 ◽  
Vol 12 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Yo-Ichi Yamashita ◽  
Mitsuo Shimada ◽  
Eiji Tsujita ◽  
Ken Shirabe ◽  
Hiroyuki Ijima ◽  
...  
Keyword(s):  
Liver Failure ◽  
Polyurethane Foam ◽  
Support System ◽  
Packed Bed ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Group Serum

We have reported the usefulness of a polyurethane foam packed-bed culture system of hepatocyte spheroids as a hybrid artificial liver support system (PUF-HALSS). The aim of this study was to evaluate in detail the efficacy in serum parameters regarding the liver function of a larger version of the PUF-HALSS containing 2 × 1010 porcine hepatocytes for clinical use in warm ischemic liver failure pigs. Warm ischemic liver failure pigs weighing 25 kg were divided into two groups: (1) a control group (n = 3), in which each pig was attached to a PUF-HALSS without hepatocytes, and (2) a HALSS group (n = 3), in which each pig was attached to a PUF-HALSS. In the HALSS group, the increase of blood ammonia was completely suppressed and blood lactate levels were significantly suppressed. The Fisher's ratio was better maintained, and the increase of total bile acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid was significantly suppressed in the HALSS group. Serum creatinine levels were significantly lower, and blood glucose levels were significantly higher in the HALSS group. Serum levels of tumor necrosis factor- a were not elevated in either group. In conclusion, the larger version of the PUF-HALSS demonstrated many advantages as a liver support system in warm ischemic liver failure pigs.

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