Extracorporeal Artificial Liver Support Systems

2010 ◽  
pp. 501-519 ◽  
Author(s):  
Rafael Bañares ◽  
María-Vega Catalina
Keyword(s):  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

A New Method to Increase the Adsorption of Protein-Bound Toxins in Artificial Liver Support Systems

2014 ◽  
Vol 38 (11) ◽  
pp. 954-962 ◽  
Author(s):  
Weiping Ding ◽  
Lili Zou ◽  
Sijie Sun ◽  
Weili Li ◽  
Dayong Gao
Keyword(s):  
Support Systems ◽  
New Method ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

Artificial Liver Support Systems in the Management of Complications of Cirrhosis

2008 ◽  
Vol 28 (1) ◽  
pp. 096-109 ◽  
Author(s):  
Vanessa Stadlbauer ◽  
Nathan Davies ◽  
Sambit Sen ◽  
Rajiv Jalan
Keyword(s):  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Management Of Complications ◽  
Complications Of Cirrhosis

Numerical Simulation and Experimental Validation of Bound Solute Dialysis in Artificial Liver Support Systems

2014 ◽  
Vol 971-973 ◽  
pp. 107-110
Author(s):  
Ying Ying Pei ◽  
Yang Xu ◽  
Yi Ze Sun ◽  
Da Yong Gao ◽  
Wei Ping Ding
Keyword(s):  
Experimental Data ◽  
Numerical Simulation ◽  
Support Systems ◽  
Open Loop ◽  
Operating Conditions ◽  
Transfer Model ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Theoretical Results

Bound solute dialysis in artificial liver support systems is one of approaches to remove protein-bound toxins from patients with liver disease. In this study, a theoretical mass transfer model for bound solute dialysis considering detailed local ultrafiltration was presented. Then, the numerical simulation was performed and the theoretical results were compared with the experimental data in two dialysis modes under various operating conditions, open-loop dialysis mode (OLM) and closed-loop dialysis mode (CLM).Our results show that the theoretical results agree well with the experimental data. The theoretical model presented here can be used to accurately predict the clearance of albumin-bound toxins and optimize the treatment strategy for clinical application.

scholarly journals PGI17 ARTIFICIAL LIVER SUPPORT SYSTEMS—A MEDICAL AND HEALTH ECONOMIC HTA-REPORT

2005 ◽  
Vol 8 (6) ◽  
pp. A123
Author(s):  
FP Hessel ◽  
K Grabein ◽  
P Schnell-Inderst ◽  
U Siebert ◽  
J Wasem
Keyword(s):  
Health Economic ◽  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

scholarly journals Serum Lactate: Creatinine Ratio as a Prognostic Marker for Liver Failure Patients Treated by artificial liver support systems

2020 ◽  
Author(s):  
Shuilin Sun ◽  
Ling Chen ◽  
Guanlin Zhou ◽  
Lili Guo ◽  
Yunquan Cai ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support Systems ◽  
Cohort Analysis ◽  
Proton Nuclear Magnetic Resonance ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Time Activity ◽  
Middle Stage ◽  
Death Group

Abstract Background: To screen potential serum prognostic markers for patients with liver failure treated by artificial liver support systems (ALSSs).Methods: Serum samples were obtained from 57 liver-failure patients before and after ALSSs therapy and analyzed by proton nuclear magnetic resonance. The diagnostic values were evaluated by calculation of the area under a receiver-operating characteristic curve (AUROC). Two retrospective analyses were further employed.Results: Metabonomics analysis showed that ratios of creatine:creatinine, taurine:creatinine, and lactate:creatinine were significantly altered and restored to normal levels after ALSSs treatment. The ratio of lactate:creatinine showed the highest AUROC value (0.650), which was higher than that of the prothrombin time activity (PTA, 0.562). A total of 105 cases of retrospective analysis showed that serum lactate:creatinine ratios among the liver-failure patients were 0.038 ± 0.002 (survival group, n=48), 0.048 ± 0.005 (three-month death group, n=24), and 0.052 ± 0.005 (one-month death group, n=33), which was significantly negatively correlated with survival (r= - 0.26). Another retrospective cohort analysis (n=81) of the early to middle stage liver-failure patients treated by ALSSs showed that the AUROC of the lactate:creatinine ratio for diagnosis of those who survived for one subsequent month was 0.827, which was higher than that of PTA (0.628) and lactate (0.765).Conclusion: The serum lactate:creatinine ratio may be a more sensitive measure than either the PTA or the lactate to evaluate the prognosis of ALSSs treatment in early to middle stage of liver-failure patients. This finding is worthy of further study in clinical applications.

scholarly journals Extracorporeal artificial liver support systems in the management of intractable cholestatic pruritus

2011 ◽  
Vol 31 ◽  
pp. 31-33 ◽  
Author(s):  
Valentin Fuhrmann ◽  
Andreas Drolz ◽  
Michael Trauner
Keyword(s):  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support
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