Initial hypotensive therapy of primary glaucoma with the domestic latanoprost generic: efficacy and safety

Purpose: a comparative study of the efficacy and safety of the Latanoprost-Optic drug and the original latanoprost drug administered to previously untreated patients with primary open-angle glaucoma (POAG). Material and methods. A double-blind, randomized, parallel-group study involved 60 patients (70 eyes) with newly diagnosed POAG, who were randomly divided into 2 groups of equal size. The patients of the main group (34 eyes) received Latanoprost-Optic, whilst the control group received the original preparation of latanoprost, 1 instillation in the evening. The reference points were the values of intraocular pressure, visual acuity, perimetric indices (standard deviation, standard deviation pattern), the average thickness of the retinal nerve fiber layer, the minimum width of the neuroretinal girdle, the thickness of the retinal nerve fiber layer in the macula, the thickness of the ganglion cell layer in the macula, the thickness of the inner plexiform layer, and the safety (adverse events). The observation period was 12 weeks. Results. After 2 weeks, both groups showed a statistically significant decrease in intraocular pressure, which remained stable after 6 and 12 weeks. The average decrease in intraocular pressure of those receiving Latanoprost-Optic was 30% and at no control point a statistically significant difference from the original drug was revealed. A positive dynamic of visual acuity, static perimetry indices and optical coherence tomography was registered, showing n significant intergroup differences. This may indicate that the drugs have an indirect neuroprotective effect. The adverse events included discomfort and redness of the bulbar conjunctiva, which were recorded in 7 out of 30 patients in the study group and in 6 out of 30 patients in the control group. All of them were mild and completely reversible. No serious or systemic adverse events were reported. Conclusion. Latanoprost-Optic has an efficacy comparable to that of the original latanoprost drug and has a comparable favorable safety profile.

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Does Septorhinoplasty-Related Periorbital Edema Affect Intraocular Pressure and Retina?

Ear Nose & Throat Journal ◽

10.1177/0145561319875734 ◽

2019 ◽

pp. 014556131987573

Author(s):

Oğuzhan Dikici ◽

Süay Özmen ◽

Gülçin Kazaz Dikici ◽

Nuray Bayar Muluk ◽

Çağla Çapkur Akkuzu

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Ganglion Cell Complex ◽

Open Rhinoplasty ◽

Periorbital Edema ◽

Fiber Layer ◽

Nerve Fiber Layer

Background: Open rhinoplasty has been performed for over 50 years. Rhinoplasty procedures have a risk of complications and it is important to follow each step diligently in order to avoid complications. Periorbital edema is the most common complication of septorhinoplasty. As far as we are aware, there are no studies in the available literature examining the impact of the septorhinoplasty on intraocular pressure and the retina. Objectives: The aim of this study was to evaluate the effects of septorhinoplasty-related periorbital edema on intraocular pressure and the retina by means of objective tests. Methods: Ten patients with phase 4 periorbital edema (5 males and 5 females) who underwent open rhinoplasty with bilateral lateral osteotomies were enrolled in the study. All the patients were examined by an eye specialist for visual acuity, intraocular pressure, retinal nerve fiber layer, and ganglion cell complex pathologies with optical coherence tomography preoperatively and postoperatively on the seventh day. Results: Preoperative and postoperative best-corrected visual acuity; intraocular pressure; average, superior, and inferior retinal nerve fiber layer thickness; and total, superior, and inferior ganglion cell complex thickness in both eyes for all patients were within normal limits. There was no statistical difference between preoperative and postoperative values ( P > .05). Conclusion: We concluded that periorbital edema after septorhinoplasty causes no significant complications affecting intraocular pressure and visual acuity. We believe that when osteotomies and local anesthetic injections are undertaken correctly, periorbital complications do not affect vision.

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Effects of testosterone on intraocular pressure, thicknesses of retinal nerve fiber layer, ganglion cell complex, macula and on ocular blood flow in female-to-male transgender persons

International Ophthalmology ◽

10.1007/s10792-021-01921-y ◽

2021 ◽

Author(s):

Oksan Alpogan ◽

Emin Erhan Donmez ◽

Ayşe Özlem Balık ◽

Fisun Vural ◽

Gizem Kaplan

Keyword(s):

Blood Flow ◽

Intraocular Pressure ◽

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Ocular Blood Flow ◽

Ganglion Cell Complex ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Transgender Persons

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Association between Rates of Retinal Nerve Fiber Layer Thinning after Intraocular Pressure–Lowering Procedures and Disc Hemorrhage

Ophthalmology Glaucoma ◽

10.1016/j.ogla.2019.11.002 ◽

2020 ◽

Vol 3 (1) ◽

pp. 7-13 ◽

Cited By ~ 2

Author(s):

Huiyuan Hou ◽

Sasan Moghimi ◽

Linda M. Zangwill ◽

James A. Proudfoot ◽

Tadamichi Akagi ◽

...

Keyword(s):

Intraocular Pressure ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Disc Hemorrhage ◽

Nerve Fiber Layer ◽

Pressure Lowering ◽

Retinal Nerve Fiber

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Changes in Intraocular Pressure and Corneal and Retinal Nerve Fiber Layer Thicknesses in Hypothyroidism

European Journal of Ophthalmology ◽

10.1177/112067210501500506 ◽

2005 ◽

Vol 15 (5) ◽

pp. 556-561 ◽

Cited By ~ 18

Author(s):

U.A. Bahçeci ◽

Ş. Özdek ◽

Z. Pehlivanli ◽

I. Yetkin ◽

M. Önol

Keyword(s):

Intraocular Pressure ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Scanning Laser ◽

Fiber Layer ◽

Serum Free ◽

Correlation Test ◽

Nerve Fiber Layer ◽

The Mean ◽

Spearman’S Correlation

Purpose To evaluate the changes in intraocular pressure (IOP), corneal thickness (CT), and retinal nerve fiber layer thickness (RNFLT) in patients with hypothyroidism before and after treatment. Methods A complete ophthalmic examination including visual acuity, IOP, anterior segment, and fundus examination together with CT and RNFLT measurements were performed for each patient with newly diagnosed hypothyroidism, at the initial diagnosis and the third and ninth months of the L-thyroxine treatment. Wilcoxon signed rank test and Spearman's correlation test were used for statistical evaluation of the results. Results A total of 56 eyes of 28 patients were included in the study. The mean IOP and CT values were found to decrease with medical treatment (p=0.000). There was no significant change in any of the RNFLT parameters measured with scanning laser Polarimeter after L-thyroxine treatment (Wilcoxon, p>0.05). The change in IOP levels was not correlated with the change in thyroid hormone levels (Spearman's correlation test, p>0.05). The mean increase in serum free T3 and serum free T4 levels and the mean decrease in serum TSH levels at the ninth month of the therapy were found to be correlated with the decrease in CT in the left eyes (Spearman's correlation test, R>0.4 and p<0.05). Conclusions Hypothyroidism seems to cause a reversible increase in CT and IOP. IOP changes may be secondary to CT changes. RNFLT parameters measured with scanning laser Polarimeter do not seem to be affected by hypothyroidism. When the CT is taken into account and the IOPs corrected for CT, the prevalence of glaucoma in hypothyroidism may not be as high as previously reported. This issue should be taken into account while assessing glaucoma in patients with hypothyroidism.

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Altered Retinal Nerve Fiber Layer Thickness and Choroid Thickness in Patients with Migraine

European Neurology ◽

10.1159/000494671 ◽

2018 ◽

Vol 80 (3-4) ◽

pp. 130-137 ◽

Cited By ~ 5

Author(s):

Ran Ao ◽

Rongfei Wang ◽

Mo Yang ◽

Shihui Wei ◽

Xuehui Shi ◽

...

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Migraine With Aura ◽

Retinal Nerve Fiber Layer ◽

Enhanced Depth Imaging ◽

Control Group ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Retinal Nerve Fiber

Background: Migraine is a chronic neurological disorder. However, its pathogenesis is still unclear. This study aimed to measure the posterior ocular structure in patients with migraine using enhanced depth imaging (EDI)-optical coherence tomography (OCT) and explore the probable pathogenesis of migraine. Methods: A total of 115 patients diagnosed with migraine and 50 healthy volunteers were recruited. These participants underwent an ocular examination to exclude the ocular diseases. Retinal nerve fiber layer thickness, macular thickness, and choroid thickness were assessed using EDI-OCT. Results: The nasal peripapillary retinal nerve fiber layer (pRNFL) was significantly thinner in the migraine with aura group (p = 0.001) than that in the control group. The inferior inner macular layer was thinner in the migraine with aura group (p = 0.005). The 3 subfields of choroid were significantly thinner in the migraine with aura group (p = 0.044, 0.008, and 0.029). However, there was no difference between the migraine without aura group and the control group. The nasal pRNFL in migraine with aura was negatively correlated with the product of duration (months) and number of attacks/month (p = 0.039). Conclusion: The changes in the ocular posterior structure may serve as evidence of the trigeminovascular system mechanism underlying migraine and transneuronal retrograde degeneration of the primary visual cortex, which reflects the cortical spreading depression.

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Choroidal thickness and retinal nerve fiber layer analysis in acute systemic brucellosis

European Journal of Inflammation ◽

10.1177/20587392211040666 ◽

2021 ◽

Vol 19 ◽

pp. 205873922110406

Author(s):

Kürşad Ramazan Zor ◽

Tuğba Arslan Gülen ◽

Gamze Yıldırım Biçer ◽

Erkut Küçük ◽

Ayfer İmre ◽

...

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Choroidal Thickness ◽

Control Group ◽

Fiber Layer ◽

Subfoveal Choroidal Thickness ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

The Mean ◽

Retinal Nerve Fiber

Introduction This study aims to detect changes in choroidal thickness and retinal nerve fiber layer (RNFL) thickness in acute stage brucellosis. Methods Fnewly diagnosed patients with acute brucellosis and 19 healthy individuals as control group were included in the study. Choroidal thickness and RNFL thickness were measured using the Spectral Domain Cirrus OCT Model 400 (Carl Zeiss Meditec, Jena, Germany) for each participant in the patient and control group. Results In the brucella group, in the right eyes, the mean nasal choroidal thickness was 272.77 ± 50.26 μm ( p = 0.689), the mean subfoveal choroidal thickness was 321.14 ± 33.08 μm ( p = 0.590), the mean temporal choroidal thickness was 278.86 ± 48.84 μm ( p = 0.478), and the mean RNFL thickness was 90.43 ± 8.93 μm ( p = 0.567). In the left eyes, the mean nasal choroidal thickness was 282.29 ± 48.93 μm ( p = 0.715), the mean subfoveal choroidal thickness was 316.79 ± 39.57 μm ( p = 0.540), the mean temporal choroidal thickness was 284.93 ± 50.57 μm ( p = 0.392), and the mean RNFL thickness was 92.64 ± 8.95 μm ( p = 0.813). Conclusion No difference was found between the control and the brucella groups regarding to all choroidal regions and RNFL thickness.

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