scholarly journals Impact of newly developed, next-generation artificial endocrine pancreas

2015 ◽  
Vol 62 (1.2) ◽  
pp. 41-44 ◽  
Author(s):  
Noriko Kambe ◽  
Shinji Kawahito ◽  
Naoji Mita ◽  
Kazumi Takaishi ◽  
Toshiko Katayama ◽  
...  
Keyword(s):  
Endocrine Pancreas ◽  
Next Generation ◽  
Artificial Endocrine Pancreas

scholarly journals Blood glucose control by an artificial endocrine pancreas in a patient with phaeochromocytoma

1985 ◽  
Vol 32 (5) ◽  
pp. 538-542
Author(s):  
Masayasu Hamaji ◽  
Masahiko Miyata ◽  
Ryuzo Kawamori ◽  
Motoaki Shichiri ◽  
Takashi Mashimo ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Endocrine Pancreas ◽  
Blood Glucose Control ◽  
Artificial Endocrine Pancreas

Metabolic response of normal man and insulin-infused diabetics to postprandial exercise

1982 ◽  
Vol 242 (5) ◽  
pp. E309-E316 ◽  
Author(s):  
J. D. Nelson ◽  
P. Poussier ◽  
E. B. Marliss ◽  
A. M. Albisser ◽  
B. Zinman
Keyword(s):  
Insulin Infusion ◽  
Closed Loop ◽  
Endocrine Pancreas ◽  
Metabolic Response ◽  
Insulin Requirement ◽  
Open Loop ◽  
Artificial Endocrine Pancreas ◽  
Intravenous Insulin ◽  
Fasting Glycemia ◽  
Identical Manner

Physical exercise is often performed during absorption of meals. We have characterized the metabolic response to 45 min of moderate exercise (approximately 55% of estimated maximal oxygen uptake) beginning 30 min after breakfast in seven healthy controls. Nine insulin-dependent diabetes were studied in an identical manner, with glycemia controlled by a closed-loop "artificial endocrine pancreas" controlled by a closed-loop "artificial endocrine pancreas" (AEP). Responses were compared to those during breakfast without exercise. In the controls, onset of exercise rapidly reversed the rise in both glycemia and insulin (IRI) that occurred with breakfast alone, both returning to fasting levels (glycemia, 80 +/- 3 mg/dl; IRI, 0.38 +/- 0.10 ng/ml). After exercise, small and transient increments occurred (glycemia, 33 +/- 6 mg/dl; IRI, 0.81 +/- 0.15 ng/ml). In the diabetics, prior overnight intravenous insulin normalized fasting glycemia (98 +/- 4 mg/dl), and its postbreakfast excursion was identical to that of controls, as were those of most measured substrates. Similarly, with exercise, glycemia returned rapidly to fasting levels, accompanied by an appropriate decrease in insulin infusion rates. "Free" IRI levels mirrored changes in infusion rates by the AEP, with a decrease in insulin requirement of 30% during exercise as compared to breakfast alone (P less than 0.05). Thus, in both diabetics treated with the AEP and in normals, the responses to postprandial exercise required rapid modulation of insulin delivery. To demonstrate the effect of postprandial exercise on preprogrammed open-loop insulin replacement, four diabetic subjects were studied during breakfast with and without exercise while receiving a fixed open-loop insulin infusion pattern (6.1 +/- 0.7 U over 140 +/- 8 min). The glycemic response to breakfast alone was entirely normalized. However, symptomatic hypoglycemia occurred in all subjects when exercise was initiated 30 min after breakfast. The diabetic responses to closed-loop insulin infusion provide important data in defining the appropriate preprogrammed open-loop insulin infusion pattern for postprandial exercise.

Biologic Activities of Biosynthetic Human Insulin in Healthy Volunteers and Insulin-dependent Diabetic Patients Monitored by the Artificial Endocrine Pancreas

Diabetes Care ◽  
1981 ◽  
Vol 4 (2) ◽  
pp. 155-162 ◽  
Author(s):  
S. Raptis ◽  
C. Karaiskos ◽  
F. Enzmann ◽  
D. Hatzidakis ◽  
C. Zoupas ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Human Insulin ◽  
Endocrine Pancreas ◽  
Diabetic Patients ◽  
Artificial Endocrine Pancreas ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Biosynthetic Human Insulin

scholarly journals What is artificial endocrine pancreas? Mechanism and history

2009 ◽  
Vol 15 (33) ◽  
pp. 4105 ◽  
Author(s):  
Kenro Nishida ◽  
Seiya Shimoda ◽  
Kenshi Ichinose ◽  
Eiichi Araki ◽  
Motoaki Shichiri
Keyword(s):  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas

scholarly journals The Development of a Counterregulatory System for an Artificial Endocrine Pancreas

1983 ◽  
Vol 59 (3) ◽  
pp. 273-286
Author(s):  
Tomonori SASAI
Keyword(s):  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas

In Vitro Culture and Transplantation of Encapsulated Human Fetal Islets as an Artificial Endocrine Pancreas

1989 ◽  
Vol 35 (3) ◽  
pp. 736-738
Author(s):  
ZHAO G. Wu ◽  
ZHI Q. SHI ◽  
ZHAO N. Lu ◽  
HUA YANG ◽  
FENG Y. SHI ◽  
...  
Keyword(s):  
In Vitro Culture ◽  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas ◽  
Fetal Islets

scholarly journals Impact of using a perioperative artificial endocrine pancreas in pancreatic resection

2020 ◽  
Vol 4 (5) ◽  
pp. 591-596
Author(s):  
Toshiaki Yoshimoto ◽  
Tetsuya Ikemoto ◽  
Yuji Morine ◽  
Satoru Imura ◽  
Yu Saito ◽  
...  
Keyword(s):  
Pancreatic Resection ◽  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas

An Artificial Endocrine Pancreas Containing Cultured Islets of Langerhans

2008 ◽  
Vol 4 (4) ◽  
pp. 275-278 ◽  
Author(s):  
Anthony Sun ◽  
Wolf Parisius ◽  
Hilda Macmorine ◽  
Michael Sefton ◽  
Robert Stone
Keyword(s):  
Islets Of Langerhans ◽  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas

A Bio-Artificial Endocrine Pancreas for the Treatment of Diabetes

1998 ◽  
Vol 30 (2) ◽  
pp. 485-489 ◽  
Author(s):  
S Hirotani ◽  
H Ohgawara ◽  
T Agishi ◽  
T Akaike ◽  
S Miyazaki
Keyword(s):  
Endocrine Pancreas ◽  
Artificial Endocrine Pancreas ◽  
Treatment Of Diabetes
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