The Anti-Apoptotic Mechanism of Action of a Water Soluble Curcumin Derivative and Mscs in Alzheimer Disease Induced In Rats

2013 ◽  
Vol 33 (2) ◽  
pp. 145-160
Author(s):  
MT Abdel Aziz ◽  
Ameen Rizk ◽  
HH Ahmed ◽  
LA Rashed ◽  
M Sohier ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mechanism Of Action ◽  
Water Soluble ◽  
Curcumin Derivative ◽  
Apoptotic Mechanism

scholarly journals Xylazine as a Drug of Abuse and Its Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Luz Silva-Torres ◽  
Christian Veléz ◽  
Lyvia Álvarez ◽  
Beatriz Zayas
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Dna Fragmentation ◽  
Mechanism Of Action ◽  
Umbilical Vein ◽  
Positive Control ◽  
Potential Health ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells ◽  
Apoptotic Mechanism

Human xylazine (XYL) abuse among addicts has received great interest due to its potential toxic effects upon addicts and the need to understand the mechanism of action associated with the potential health effects. XYL is an alpha-2 agonist restricted to veterinarian applications, without human medical applications. Our previous work demonstrated that XYL and its combination with cocaine (COC) and/or 6-monoacetylmorphine (6-MAM) induce cell death through an apoptotic mechanism. The aim of this study was to determine the effect of xylazine on the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as well as DNA damage on endothelial cell. Human umbilical vein endothelial cells (HUVEC) were treated with XYL (60 μM), COC (160 μM), 6-MAM (160 μM), camptothecin (positive control, 50 μM), XYL/COC (50 μM), XYL/6-MAM (50 μM), and XYL/COC/6-MAM (40 μM) for a period of 24 hours. Generation of intracellular ROS, RNS, and DNA fragmentation were analyzed using a fluorometric assay. Results reveal that XYL and 6-MAM increase levels of ROS; no induction of RNS production was observed. The combination of these drugs shows significant increase in DNA fragmentation in G2/M phase, while XYL, COC, and 6-MAM, without combination, present higher DNA fragmentation in G0/G1 phase. These findings support that these drugs and their combination alter important biochemical events aligned with an apoptotic mechanism of action in HUVEC.

scholarly journals Efficacy of a novel water soluble curcumin derivative versus Tadalafile in mediating erectile function

2015 ◽  
Vol 1 (5) ◽  
pp. 206-212
Author(s):  
SA.M. Zaahkouk ◽  
G.A Hesham ◽  
Yehia M. Hussein ◽  
H.M Atta ◽  
Fouad Hanan
Keyword(s):  
Erectile Function ◽  
Water Soluble ◽  
Curcumin Derivative

scholarly journals THE MECHANISM OF ACTION OF WATER-SOLUBLE VITAMINS

1962 ◽  
Vol 244 (2) ◽  
pp. 263
Author(s):  
A. V. S. DE REUCK ◽  
MAEVE O??CONNOR
Keyword(s):  
Mechanism Of Action ◽  
Water Soluble

White sesame seed water-soluble fraction enhances human neuroblast cell viability via an anti-apoptotic mechanism

2016 ◽  
Vol 36 (10) ◽  
pp. 1130-1139 ◽  
Author(s):  
Sana Ben Othman ◽  
Nakako Katsuno ◽  
Akemi Kitayama ◽  
Makoto Fujimura ◽  
Kohji Kitaguchi ◽  
...  
Keyword(s):  
Cell Viability ◽  
Soluble Fraction ◽  
Sesame Seed ◽  
Water Soluble ◽  
Water Soluble Fraction ◽  
Apoptotic Mechanism

scholarly journals Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)

2012 ◽  
Vol 4 (1) ◽  
Author(s):  
Mohamed T Abdel Aziz ◽  
Mohamed F El-Asmar ◽  
Ibrahim N El-Ibrashy ◽  
Ameen M Rezq ◽  
Abdulrahman L Al-Malki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Water Soluble ◽  
Short Term ◽  
Term Study ◽  
Short Term Study ◽  
Experimental Type ◽  
Curcumin Derivative

scholarly journals Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Mohamed Talaat Abdel Aziz ◽  
Ibrahim Naguib El Ibrashy ◽  
Dimitri P Mikhailidis ◽  
Ameen Mahmoud Rezq ◽  
Mohamed Abdel Aziz Wassef ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Water Soluble ◽  
Signaling Mechanisms ◽  
Experimental Type ◽  
Curcumin Derivative
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