scholarly journals Autologus Serum Therapy Efficacy as Adjunctive Treatment to Antihistaminics in Chronic Spontaneous Urticaria Patients.

2020 ◽  
Vol 1 (1) ◽  
pp. 29-41
Author(s):  
Heba El-Sayed
Keyword(s):  
Chronic Spontaneous Urticaria ◽  
Adjunctive Treatment ◽  
Therapy Efficacy ◽  
Serum Therapy

scholarly journals Autologous serum therapy: a viable option for chronic spontaneous urticaria

2020 ◽  
Vol 7 (1) ◽  
pp. 69
Author(s):  
Darshana Sundaresh ◽  
S. Kumaravel ◽  
M. Anbumalar
Keyword(s):  
Chronic Urticaria ◽  
Adjunctive Treatment ◽  
Autologous Serum ◽  
Viable Option ◽  
Positive Skin ◽  
Female Predominance ◽  
Quasi Experimental ◽  
Study Population ◽  
Serum Therapy

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is a common disorder causing decrease in quality of life of patients with associated morbidity, chronic dependence on medications and a huge pill burden. CU is multifactorial and a subset of patients have an autoimmune background for their condition which is confirmed by a positive skin reaction to ASST. This study compared the efficacy of Autologous serum therapy in both ASST positive and ASST negative patients by evaluating total severity score (TSS).</p><p class="abstract"><strong>Methods: </strong>This quasi experimental study was conducted on fifty patients were selected randomly and withdrawn from antihistaminic use. ASST was done for all patients and AST was administered to all patients in both groups for 9 weeks. The patients were followed up at 4 weeks and 12 weeks after completion of AST. TSS measurements were used as baseline and recorded weekly after each injections till 9 weeks then 4th and 12th week after completion of therapy.</p><p class="abstract"><strong>Results:</strong> 50 patients were the study population. The median age was 34.7 years with a female predominance. 23 patients were ASST positive and the rest were negative. Following treatment, ASST positive group had 69% improvement in TSS and ASST negative group had 61.5% improvement in TSS. There was statistically significant differences following treatment compared to baseline and between the two groups.</p><p><strong>Conclusions:</strong> AST as an adjunctive treatment for chronic urticaria shows promise for patients irrespective of ASST positivity and is more effective for ASST positive patients.</p>

Modern anti-IgE therapies in children with chronic spontaneous urticaria: clinical cases

2021 ◽  
Vol 17 (4) ◽  
pp. 85-89
Author(s):  
Inna A. Larkova ◽  
Vera A. Revyakina
Keyword(s):  
Chronic Urticaria ◽  
Clinical Manifestations ◽  
Chronic Spontaneous Urticaria ◽  
First Line ◽  
Therapy Efficacy ◽  
Number Of Patients ◽  
H1 Antihistamines ◽  
Urticaria Treatment ◽  
Clinical Cases

The diagnostics and treatment of chronic urticaria is still a pressing problem for specialists of different profiles. Despite the fact that the first line drugs for urticaria treatment are non-sedating H1- antihistamines, there are a number of patients who do not respond to these medications even in their increased doses. This article presents clinical cases of anti-IgE-therapy efficacy in children suffering from urticaria and angioedema. CONCLUSION: The clinical cases demonstrate current possibilities of successful and safe anti-IgE-therapy of various clinical manifestations of chronic spontaneous urticaria and angioedema in children.

Clinical Response to Questions Regarding Outcomes and Therapy Efficacy

2010 ◽  
Vol 20 (3) ◽  
pp. 76-83 ◽  
Author(s):  
Joseph Donaher ◽  
Tom Gurrister ◽  
Irving Wollman ◽  
Tim Mackesey ◽  
Michelle L. Burnett
Keyword(s):  
Risk Factors ◽  
Clinical Response ◽  
Speech Language Pathologists ◽  
Specific Therapy ◽  
Therapy Efficacy ◽  
Therapy Program ◽  
Adults Who Stutter ◽  
Cure Rates

Parents of children who stutter and adults who stutter frequently ask speech-language pathologists to predict whether or not therapy will work. Even though research has explored risk-factors related to persistent stuttering, there remains no way to determine how an individual will react to a specific therapy program. This paper presents various clinicians’answers to the question, “What do you tell parents or adults who stutter when they ask about cure rates, outcomes, and therapy efficacy?”

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