Autoimmune thyroiditis and chronic spontaneous urticaria - case series

2018 ◽  
Author(s):  
Cristina Ene ◽  
Elena Madalan
Keyword(s):  
Autoimmune Thyroiditis ◽  
Case Series ◽  
Chronic Spontaneous Urticaria

scholarly journals Combination therapy of omalizumab with house dust mite immunotherapy in chronic spontaneous urticaria associated with sensitization to dust mites-case series

2021 ◽  
pp. 469-472
Author(s):  
P C Kathuria ◽  
Manisha Rai
Keyword(s):  
Combination Therapy ◽  
Disease Control ◽  
House Dust ◽  
House Dust Mite ◽  
Immunoglobulin E ◽  
Combined Therapy ◽  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Dust Mite ◽  
Urticaria Activity Score

Chronic spontaneous urticaria (CSU) is a heterogeneous disorder with recurrent pruritic wheals and/or angioedema. The anti-immunoglobulin E (omalizumab) is used in CSU patients resistant to four-fold second-generation anti-histamines. Most clinical trials have experienced relapse after stopping omalizumab treatment. Here, we present a case series of five cases of chronic atopic urticarial concomitant allergic rhinitis and asthma which have shown immunologically significant positivity to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Disease control was achieved (Urticaria Activity Score 7 <6) in four cases by combination therapy of omalizumab with house dust mite (HDM) Allergen Immunotherapy (AIT) and remained sustained for three years on follow-up even after discontinuation of AIT for one year. We hypothesize that this combined therapy may contribute to enhanced clinical efficacy, safety, and faster achievement of disease control in CSU.

scholarly journals COVID-19 Disease Leading to Chronic Spontaneous Urticaria Exacerbation: A Romanian Retrospective Study

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1144
Author(s):  
Ioana Adriana Muntean ◽  
Irena Pintea ◽  
Ioana Corina Bocsan ◽  
Carmen Teodora Dobrican ◽  
Diana Deleanu
Keyword(s):  
Inflammatory Markers ◽  
Clinical Presentation ◽  
Significant Proportion ◽  
Case Series ◽  
Treated Group ◽  
Severe Form ◽  
Chronic Spontaneous Urticaria ◽  
Retrospective Case ◽  
Markers Of Inflammation ◽  
Urticaria Activity Score

(1) Background: The COVID-19 pandemic has resulted in the exacerbation of various chronic diseases. Due to the potential impact of SARS-CoV-2 on mast cells, we aimed to analyze the relevance of COVID-19 disease on chronic spontaneous urticaria (CSU) clinical presentation and biological profile. (2) Methods: This study is a retrospective case series of patients with CSU diagnosed and treated in the Allergy Department of the Professor Doctor Octavian Fodor RIGH, (Cluj-Napoca, Romania). Patients were assessed for disease activity and level of control with the weekly urticaria activity score and the visual analogue scale. Results were correlated with COVID-19 severity and with nonspecific markers of inflammation during and after the SARS-CoV-2 infection. (3) Results: SARS-CoV-2 impacted a significant proportion (33%) of the CSU patients, of which 71% developed a moderate-severe form of COVID-19. Most of the patients (68%) had moderate-severe forms of CSU and 65% took AH1 treatment (one dose, two-fold dose or four-fold dose). The rest of them (35%) received the second-line treatment (40.3% Omalizumab, 53% Prednisolone and 4.8% Cyclosporine). In Omalizumab treated group of UCS patients we observed that COVID-19 disease was not severe. We established a positive correlation between the severity of the infection and that of the CSU clinical presentation, with most bothersome symptoms of urticaria being experienced by moderate to severe COVID-19 CSU patients (47%). Inflammatory markers were positively correlated (p = 0.01) with a more severe clinical profile of CSU, in accordance with our hypothesis that the level of inflammation triggered by COVID-19 disease has a role in CSU exacerbation. The non-specific inflammatory markers, such as CRP, were positively associated with the UAS7 score (R2 = 0.363; p = 0.001). An increased rate of exacerbation of CSU was observed in moderate-severe COVID-19 infection. 4) Conclusions: COVID-19 disease can result in the exacerbation of chronic spontaneous urticaria, more likely in moderate to severe forms of infection.

Rarity of Encephalopathy Associated with Autoimmune Thyroiditis: A Case Series from Mayo Clinic from 1950 to 1996

Thyroid ◽  
2002 ◽  
Vol 12 (5) ◽  
pp. 393-398 ◽  
Author(s):  
Anna M. Sawka ◽  
Vahab Fatourechi ◽  
Bradley F. Boeve ◽  
Bahram Mokri
Keyword(s):  
Autoimmune Thyroiditis ◽  
Mayo Clinic ◽  
Case Series

scholarly journals A Case Series Study of Eighty-Five Chronic Spontaneous Urticaria Patients Referred to a Tertiary Care Center

2014 ◽  
Vol 26 (1) ◽  
pp. 73 ◽  
Author(s):  
Line Kibsgaard ◽  
Anna Cecile Lefevre ◽  
Mette Deleuran ◽  
Christian Vestergaard
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Tertiary Care Center ◽  
Case Series Study ◽  
Series Study

Chronic Spontaneous Urticaria

2015 ◽  
Vol 20 (3) ◽  
pp. 241-243 ◽  
Author(s):  
Natasha Gattey ◽  
Bahar Bahrani ◽  
Peter R. Hull
Keyword(s):  
Autoimmune Diseases ◽  
Autoimmune Thyroiditis ◽  
Age Of Onset ◽  
Average Duration ◽  
Chronic Spontaneous Urticaria ◽  
Duration Of Symptoms ◽  
Disturbed Sleep ◽  
Significant Disability ◽  
History Of ◽  
The Mean

Background: Chronic spontaneous urticaria (CSU) is urticaria persisting for more than 6 weeks with no identifiable provoking cause and associated with significant disability. Objectives: The aim of this study was to survey patients with CSU with a view to establishing prognosis, efficacy of treatments, suspected causality, and effects on lifestyle. Methods: One hundred seventy-four patients with CSU were seen between 2003 and 2013. A questionnaire was sent to all, and 101 participated. Results: The ratio of female to male participants was 4:1. The mean age of onset was 36 years. The average duration of symptoms was 8.8 years, with a range of 0.33 to 55 years. Seven percent of participants had autoimmune thyroiditis, and another 17% had various other autoimmune diseases. Common symptoms were pruritus, disturbed sleep, and anxiety. Slightly more than 70% had missed work or school. Most were frustrated at the lack of efficacy of treatments. Conclusions CSU is frequently associated with a history of autoimmune diseases. It may persist for decades and causes significant disruption to lifestyle.

Efficacy of omalizumab treatment for pediatric chronic spontaneous urticaria: A multi‐center retrospective case series

2020 ◽  
Vol 37 (6) ◽  
pp. 1051-1054
Author(s):  
Anne Ari ◽  
Yael Levy ◽  
Nirit Segal ◽  
Ramit Maoz‐Segal ◽  
Shira Benor ◽  
...  
Keyword(s):  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Retrospective Case ◽  
Retrospective Case Series

scholarly journals Successful Treatment of Chronic Spontaneous Urticaria Associated with Autoimmune Thyroiditis: Clinical Case

2019 ◽  
Vol 16 (4) ◽  
pp. 229-233
Author(s):  
Vera G. Kalugina ◽  
Leyla S. Namazova-Baranova ◽  
Elena A. Vishnyova ◽  
Anna A. Alexeyeva ◽  
Yliya Levina ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Autoimmune Thyroiditis ◽  
Clinical Case ◽  
Chronic Spontaneous Urticaria

Omalizumab in children and adolescents with chronic spontaneous urticaria: Case series and review of the literature

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Stefano Passanisi ◽  
Stefania Arasi ◽  
Lucia Caminiti ◽  
Giuseppe Crisafulli ◽  
Giuseppina Salzano ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Review Of The Literature

scholarly journals Brain Injury Associated with Chronic Spontaneous Urticaria: a Kounis-Like Syndrome?

2020 ◽  
Vol 77 (4) ◽  
pp. 345-347
Author(s):  
Luis Santiago ◽  
Margarida Gonçalo
Keyword(s):  
Brain Injury ◽  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Neurological Manifestations ◽  
Cerebral Vasculature ◽  
Vascular Risk ◽  
Kounis Syndrome ◽  
Neurologic Symptoms ◽  
Coagulation Abnormalities ◽  
Multiple Recurrences

‘Kounis Syndrome’ is an acute coronary artery event due to an artery spasm occurring during immediate hypersensi- tivity reactions or chronic spontaneous urticaria. Recently it has been reported in other systems, including the cerebral vasculature. We present a case series of three patients observed between January 2016 and December 2018 with acute and transient brain injury associated with concomitant exacerbation of chronic spontaneous urticaria, including one patient with multiple recurrences of neurologic symptoms during exacerbations of urticaria. Minor imaging defects were observed in two patients, but there were no apparent vascular risk factors or coagulation abnormalities that might explain neurologic symptoms. Chronic spontaneous urticaria, through activation of mast cells and mediator release, seems capable of inducing cerebral arterial aggression. The authors want to call the attention to this possible association, reinforcing the need to keep urticaria under control to prevent neurological manifestations.

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