scholarly journals Autologous serum therapy: a viable option for chronic spontaneous urticaria

2020 ◽  
Vol 7 (1) ◽  
pp. 69
Author(s):  
Darshana Sundaresh ◽  
S. Kumaravel ◽  
M. Anbumalar
Keyword(s):  
Chronic Urticaria ◽  
Adjunctive Treatment ◽  
Autologous Serum ◽  
Viable Option ◽  
Positive Skin ◽  
Female Predominance ◽  
Quasi Experimental ◽  
Study Population ◽  
Serum Therapy

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is a common disorder causing decrease in quality of life of patients with associated morbidity, chronic dependence on medications and a huge pill burden. CU is multifactorial and a subset of patients have an autoimmune background for their condition which is confirmed by a positive skin reaction to ASST. This study compared the efficacy of Autologous serum therapy in both ASST positive and ASST negative patients by evaluating total severity score (TSS).</p><p class="abstract"><strong>Methods: </strong>This quasi experimental study was conducted on fifty patients were selected randomly and withdrawn from antihistaminic use. ASST was done for all patients and AST was administered to all patients in both groups for 9 weeks. The patients were followed up at 4 weeks and 12 weeks after completion of AST. TSS measurements were used as baseline and recorded weekly after each injections till 9 weeks then 4th and 12th week after completion of therapy.</p><p class="abstract"><strong>Results:</strong> 50 patients were the study population. The median age was 34.7 years with a female predominance. 23 patients were ASST positive and the rest were negative. Following treatment, ASST positive group had 69% improvement in TSS and ASST negative group had 61.5% improvement in TSS. There was statistically significant differences following treatment compared to baseline and between the two groups.</p><p><strong>Conclusions:</strong> AST as an adjunctive treatment for chronic urticaria shows promise for patients irrespective of ASST positivity and is more effective for ASST positive patients.</p>

scholarly journals Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria

2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Cost Effective ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
P Value ◽  
Prick Test ◽  
H1 Antihistamines ◽  
Serum Therapy

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.

scholarly journals EFFECTIVENESS OF AUTOLOGOUS SERUM THERAPY IN CHRONIC URTICARIA: A PROSPECTIVE OBSERVATIONAL STUDY IN TERTIARY CARE HOSPITAL

2016 ◽  
Vol 5 (17) ◽  
pp. 822-827
Author(s):  
Rakesh Kumar Patel ◽  
Anil Kumar Gupta ◽  
Santosh Kumar Singh ◽  
Harleen Chhachhi ◽  
Pawan Kumar Patel ◽  
...  
Keyword(s):  
Observational Study ◽  
Chronic Urticaria ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Autologous Serum ◽  
Care Hospital ◽  
Serum Therapy

scholarly journals Autologous serum therapy in chronic urticaria: Old wine in a new bottle

2008 ◽  
Vol 74 (2) ◽  
pp. 109 ◽  
Author(s):  
AK Bajaj ◽  
Abir Saraswat ◽  
Amitabh Upadhyay ◽  
Rajetha Damisetty ◽  
Sandipan Dhar
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Gymnastic and Warm Compression Effect on Dysmenohrea Adolescence Overcoming Behavior

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Deswani Kasim ◽  
Sri Maryani Syahlan
Keyword(s):  
Young Women ◽  
Reproductive Organs ◽  
Pain Scale ◽  
Learning Activities ◽  
Control Group ◽  
Nursing Interventions ◽  
Compression Effect ◽  
Quasi Experimental ◽  
Study Population

Changes that occur in young women entering puberty are the functioning of all reproductive organs, one of which is marked by the onset of menstruation that can cause pain during menstruation which is also called dysmenorrhea. Dysmenorrhea is a condition where a woman experiences pain before menstruation and during menstruation. Dysmenorrhea can interfere with learning activities and indirectly can also affect the productivity and quality of life of adolescents. The purpose of the study was to determine the effect of gymnastics and warm compresses on the management of dysmenorrhea and pain scale. The research design used the quasi-experimental design with the non-randomized pretest-posttest control group. The study population was 60 respondents, the results of the study of the effect of warm gymnastics and compress in reducing teenage dysmenorrhea dysmenorrhea with controlled gymnastics and warm compresses  Gymnastics and warm compresses can be recommended for teenagers and as part of nursing interventions to deal with dysmenorrhea.

scholarly journals A study of autologous serum skin test and autologous serum therapy in chronic urticaria

2018 ◽  
Vol 4 (2) ◽  
pp. 246
Author(s):  
Bharti Patel ◽  
Komal Kapadia ◽  
Khushbu Chauhan ◽  
Neela Bhuptani
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Quality Index ◽  
Life Quality ◽  
Autologous Serum ◽  
Effective Parameters ◽  
Positive Skin ◽  
Autologous Serum Skin Test ◽  
Before And After ◽  
Life Quality Index

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is a vexing problem and patients suffer from the morbidity that arise from irritable itch and wheals and are also subjected to a huge antihistamine pill burden. A subset of patients with CU may have an autoimmune basis for their condition, as shown by a positive skin test to ASST. The objective of the study was to compare efficacy of AST in ASST positive and negative patients and its impact on dermatology life quality index (DLQI) in patients, before and after AST.</p><p class="abstract"><strong>Methods:</strong> A prospective, interventional study was conducted in the Department of dermatology (Skin) OPD of our institute from October 2016 to October 2017. Fifty patients were selected randomly and antihistaminics were withdrawn before ASST. Test was performed in all patients and AST was given for 9 weeks in both (ASST positive &amp; negative) groups, along with tablet levocetrizine on demand basis and followed for 4 weeks after completion of 9 weeks of therapy. Total severity score (TSS), urticaria activity score (UAS), dermatologic life quality index (DLQI) were used as primary effective parameters and were recorded at baseline and weekly after each injections of AST.<strong></strong></p><p class="abstract"><strong>Results:</strong> UAS and TSS showed significant improvement (&gt;50%) after 5th week in both group patients. DLQI showed higher improvement in ASST positive patients.</p><p class="abstract"><strong>Conclusions:</strong> We found significant improvement in ASST positive and ASST negative patients but ASST positive patients required more time to experience the benefit of AST.</p><p class="abstract"> </p>

scholarly journals Autologous serum therapy in chronic urticaria

2019 ◽  
Vol 5 (4) ◽  
pp. 275-279
Author(s):  
Surendran K A K ◽  
◽  
Nanjundaswamy B L ◽  
Sathish S ◽  
Bangaru H ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Autologous serum therapy in chronic urticaria: A promising complement to antihistamines

2014 ◽  
Vol 59 (4) ◽  
pp. 375 ◽  
Author(s):  
NilayKanti Das ◽  
Panchami Debbarman ◽  
Amrita Sil ◽  
PiyushKanti Datta ◽  
Debabrata Bandyopadhyay
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

scholarly journals Evaluation of Serum Substance P Level in Chronic Urticaria and Correlation with Disease Severity

2020 ◽  
Author(s):  
Javad Fadaee ◽  
Maryam Khoshkhui ◽  
Maryam Emadzadeh ◽  
Seyed Isaac Hashemy ◽  
Reza Farid Hosseini ◽  
...  
Keyword(s):  
Substance P ◽  
Serum Level ◽  
Chronic Urticaria ◽  
Healthy Subjects ◽  
Background Information ◽  
Autologous Serum ◽  
Control Group ◽  
Autologous Serum Skin Test ◽  
Urticaria Activity Score

Substance P (SP) is a neurotransmitter emitted from neurons that plays a role in the pathogenesis of itching conditions including chronic urticarial (CU). The present research aims to investigate the serum level of S.P among CU patients and compare them with healthy subjects and explore how it correlates with the severity of urticaria. The present research was conducted on 87 CU patients who visited the allergy clinic of Ghaem Hospital, Mashhad, Iran from October 2017 to June 2018. Besides, 86 healthy subjects were recruited as the control group. Background information of patient was collected including age, sex, duration of the disease and the co-occurrence of angioedema. S.P serum level was measured in two groups by ELISA method. In the patients group, the autologous serum skin test (ASST) was performed along with the urticaria evaluation questionnaire include Urticaria Activity Score 7 (UAS7), Urticaria Control Test (UCT) and Chronic Urticaria Quality of Life (CU-Q2OL). Among the patients, the SP serum level showed to be about two times higher than the healthy subjects (p˂0.001). SP showed to be increased as patients’ age grew (p=0.010). In patients with a positive ASST, SP level was higher (p=0.012). No correlation was found between SP and the presence of angioedema among patients. There was no correlation between the SP serum level and the scores obtained from urticaria evaluation questionnaires. SP among CU patients was higher than healthy subjects. SP was also higher among female, older and positive ASST patients. The SP value was not correlated with the severity of urticaria, angioedema. In conclusion, Using SP antagonist drugs could be a potential treatment for chronic urticaria.

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