Drug Utilisation Review (DUR) of the Third Generation Cephalosporins

Drugs ◽  
1995 ◽  
Vol 50 (3) ◽  
pp. 423-439 ◽  
Author(s):  
Ammishaddai Adu ◽  
Carol L. Armour
Keyword(s):  
Drug Utilisation ◽  
Drug Utilisation Review ◽  
Third Generation ◽  
Utilisation Review ◽  
The Third ◽  
Third Generation Cephalosporins

Third-Generation and Investigational Cephalosporins: I. Structure-Activity Relationships and Pharmacokinetic Review

1983 ◽  
Vol 17 (7-8) ◽  
pp. 507-515 ◽  
Author(s):  
Pamela Garzone ◽  
James Lyon ◽  
Victor L. Yu
Keyword(s):  
Classification Scheme ◽  
Third Generation ◽  
Serum Concentrations ◽  
New Agents ◽  
The Third ◽  
Structure Activity ◽  
Pharmacokinetic Properties ◽  
Fluid Penetration ◽  
Third Generation Cephalosporins ◽  
Antibacterial Spectrum

The structure-relationships and pharmacokinetic properties of the new second- and third-generation cephalosporins are reviewed. The new second-generation cephalosporins include ceforanide, cefotiam, and cefuroxime. The third-generation cephalosporins include cefmenoxime, cefoperazone, cefotaxime, cefsulodin, ceftazidime, ceftizoxime, ceftriaxone, and moxalactam. These new cephalosporins are semisynthetic analogs with different chemical substitutions on a 7-aminocephalosporanic nucleus. As a result of these chemical modifications, improvements in the antibacterial spectrum as well as pharmacokinetic properties have occurred. In general, the new cephalosporins have longer half-lives, higher and prolonged serum concentrations, and increased cerebrospinal fluid penetration. Selected cephalosporins also have increased biliary tract concentrations. A classification scheme for these new agents, based on generation and susceptibility to Pseudomonas aeruginosa, is presented.

Do Practice Guidelines Augment Drug Utilisation Review?

1997 ◽  
Vol 12 (6) ◽  
pp. 648-666 ◽  
Author(s):  
Elizabeth A. Chrischilles ◽  
Kathleen Gondek
Keyword(s):  
Practice Guidelines ◽  
Drug Utilisation ◽  
Drug Utilisation Review ◽  
Utilisation Review

Medicaid Drug Utilisation Review Under OBRA 1990

1992 ◽  
Vol 2 (5) ◽  
pp. 363-370 ◽  
Author(s):  
Thomas R. Fulda ◽  
Steven L. Hass
Keyword(s):  
Drug Utilisation ◽  
Drug Utilisation Review ◽  
Utilisation Review
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