Development and Validation of a Rat Model for Examining the AT1 and ETA Receptor-Blocking Activity of Dual AT1 and ETA Receptor Blockers

2009 ◽  
Vol 16 (2) ◽  
pp. 39-45
Author(s):  
Ram Gupta ◽  
Anookh Mohanan ◽  
Deepa Joshi
Keyword(s):  
Rat Model ◽  
Receptor Blocking ◽  
Blocking Activity ◽  
Eta Receptor ◽  
Receptor Blockers ◽  
Development And Validation

scholarly journals Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: Effect of angiotensin receptor blockers

2010 ◽  
Vol 62 (5) ◽  
pp. 1319-1328 ◽  
Author(s):  
Takeo Sakuta ◽  
Yoshitaka Morita ◽  
Minoru Satoh ◽  
David A. Fox ◽  
Naoki Kashihara
Keyword(s):  
Rat Model ◽  
Angiotensin Receptor Blockers ◽  
Renin Angiotensin System ◽  
Vascular Damage ◽  
Angiotensin Receptor ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Receptor Blockers

Histamine H2-receptor blocking activity of ranitidine analogues containing 3-amino-4-alkylaminofurazan moieties

1989 ◽  
Vol 21 (1) ◽  
pp. 115-116
Author(s):  
M ORSETTI ◽  
L OGGERO ◽  
G SORBA
Keyword(s):  
Histamine H2 Receptor ◽  
Receptor Blocking ◽  
H2 Receptor ◽  
Blocking Activity

Development and validation of a UPLC-DAD method for the simultaneous quantification of eight antihypertensive drugs in the pharmaceutical matrix

2020 ◽  
Author(s):  
Miloud El Karbane ◽  
Yassine Hameda Benchekroun ◽  
Fatima Zahra Abousalih ◽  
Ismail Bennani ◽  
Mohamed Azougagh ◽  
...  
Keyword(s):  
Antihypertensive Drugs ◽  
Fixed Dose ◽  
Good Resolution ◽  
Buffer Solution ◽  
Pharmaceutical Dosage Forms ◽  
Ich Guidelines ◽  
Dihydropyridine Calcium Channel Blocker ◽  
Receptor Blockers ◽  
Dose Combination ◽  
Development And Validation

Abstract Background Hypertension is a critical health problem; it is a prevalent risk factor for cardiovascular disease. Many treatments to combat hypertension are available, while several patients are resistant to the standard therapeutic approaches. The association of two or more substances in a fixed-dose combination is effective and tolerated to substitute the standard therapeutic approach. Objective New UPLC-DAD method was developed and validated to assay a combination of eight antihypertensive drugs including a diuretic: hydrochlorothiazide, dihydropyridine calcium channel blocker: Amlodipine and angiotensin II type 1 receptor blockers (sartans): valsartan, candesartan, eprosartan, olmesartan, losartan, and irbesartan in the pharmaceutical matrix. Methods Chromatographic separation was performed on an Acquity® UPLC C18 1.7 µm 2.1 × 100 mm column, with a gradient of buffer solution and acetonitrile, in the proportion of (80:20 v/v). Results Good resolution was obtained, and an optimal analysis time of less than 5 min was achieved. The method was validated according to the International Conference on Harmonization (ICH) guidelines following the classical approach and accuracy profile, it is shown to be suitable for intended applications. The method was successfully used for quality control laboratories and the determination of these drugs combination in pharmaceutical dosage forms.

Anti-ulcer compound from Voacanga africana with possible histamine H2 receptor blocking activity

Phytomedicine ◽  
2000 ◽  
Vol 7 (6) ◽  
pp. 509-515 ◽  
Author(s):  
P.V. Tan ◽  
B. Nyasse
Keyword(s):  
Histamine H2 Receptor ◽  
Receptor Blocking ◽  
H2 Receptor ◽  
Blocking Activity

scholarly journals Studies on Cardiovascular Drugs. IV. : Adrenergic β-Receptor Blocking Activity of New Catechol Derivatives in the Guinea Pig Tracheal Strip

1971 ◽  
Vol 91 (10) ◽  
pp. 1037-1041 ◽  
Author(s):  
MICHIO NAKANISHI ◽  
HIROSHI IMAMURA ◽  
TADAO NAKAMURA ◽  
TOMOHIKO KIMURA
Keyword(s):  
Guinea Pig ◽  
Cardiovascular Drugs ◽  
Receptor Blocking ◽  
Beta Receptor ◽  
Blocking Activity

Carbamazepine derivatives with P2X4 receptor-blocking activity

2014 ◽  
Vol 22 (3) ◽  
pp. 1077-1088 ◽  
Author(s):  
Maoqun Tian ◽  
Aliaa Abdelrahman ◽  
Stephanie Weinhausen ◽  
Sonja Hinz ◽  
Stefanie Weyer ◽  
...  
Keyword(s):  
Receptor Blocking ◽  
P2x4 Receptor ◽  
Blocking Activity
Sign in / Sign up

Export Citation Format

Share Document