scholarly journals Characterization of the mammalian DNA polymerase gene(s) and enzyme(s). Annual progress report

10.2172/89557 ◽  
1995 ◽  
Author(s):  
N.C. Mishra

2009 ◽  
Vol 297 (2) ◽  
pp. 180-188 ◽  
Author(s):  
Heejin Bae ◽  
Kee Pum Kim ◽  
Jung Min Song ◽  
Jun-Hwan Kim ◽  
Joo-Sung Yang ◽  
...  


2001 ◽  
Vol 82 (11) ◽  
pp. 2761-2765 ◽  
Author(s):  
Tomoko Kamiyama ◽  
Masahiko Kurokawa ◽  
Kimiyasu Shiraki

The nucleotide changes of the DNA polymerase gene and the susceptibility of acyclovir (ACV)-resistant varicella-zoster virus (VZV) mutants to anti-herpetic drugs were determined and compared to those of herpes simplex virus type 1 (HSV-1) mutants. The seven ACV-resistant VZV mutants were classified into three groups, N779S, G805C and V855M, according to the sequences of their DNA polymerase genes. The amino acid substitutions N779S and G805C were identical in position to the N815S and G814C mutations in the HSV-1 DNA polymerase mutants, respectively, and the V855M amino acid substitution was similar to the HSV-1 V892M mutation. All three groups of VZV mutants were susceptible to ACV, phosphonoacetic acid, vidarabine and aphidicolin, at levels similar to those seen with the respective HSV-1 mutants, except for subtle differences that were due possibly to the non-conserved regions in their sequences. Although both the HSV-1 and the VZV DNA polymerase genes show 53% sequence similarity, both viruses essentially show a similar biochemical behaviour.



1998 ◽  
Vol 79 (12) ◽  
pp. 3049-3053 ◽  
Author(s):  
C Springfeld ◽  
G Darai ◽  
R Kehm ◽  
U Bahr ◽  
C A Tidona


1991 ◽  
Vol 65 (9) ◽  
pp. 4670-4680 ◽  
Author(s):  
I A Teo ◽  
B E Griffin ◽  
M D Jones


Virology ◽  
2005 ◽  
Vol 331 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Adam L. Vanarsdall ◽  
Kazuhiro Okano ◽  
George F. Rohrmann


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