Recent Advances on Nitric Oxide in the Upper Airways

2016 ◽  
Vol 23 (24) ◽  
pp. 2736-2745 ◽  
Author(s):  
Mauro Maniscalco ◽  
Andrea Bianco ◽  
Gennaro Mazzarella ◽  
Andrea Motta
Keyword(s):  
Nitric Oxide ◽  
Upper Airways ◽  
Recent Advances

scholarly journals Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria?

2018 ◽  
Vol 46 (5) ◽  
pp. 1107-1118 ◽  
Author(s):  
Lauren K. Wareham ◽  
Hannah M. Southam ◽  
Robert K. Poole
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Hydrogen Sulfide ◽  
Small Molecule ◽  
Toxic Effects ◽  
Gaseous Molecule ◽  
Recent Advances ◽  
Definition Of

A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H2S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles in addition to their toxic effects. However, strict application of the criteria proposed for a gasotransmitter leads us to conclude that the term ‘small molecule signalling agent’, as proposed by Fukuto and others, is preferable terminology.

Nitric oxide in upper airways inflammatory diseases

2007 ◽  
Vol 56 (2) ◽  
pp. 58-69 ◽  
Author(s):  
M. Maniscalco ◽  
M. Sofia ◽  
G. Pelaia
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Diseases ◽  
Upper Airways

Recent advances in stress research: Focus on nitric oxide

2015 ◽  
Vol 765 ◽  
pp. 406-414 ◽  
Author(s):  
Kavita Gulati ◽  
Jagdish Chandra Joshi ◽  
Arunabha Ray
Keyword(s):  
Nitric Oxide ◽  
Research Focus ◽  
Stress Research ◽  
Recent Advances

scholarly journals Nitric oxide gas inhalation to prevent COVID-2019 in healthcare providers

2020 ◽  
Author(s):  
Stefano Gianni ◽  
Bijan Safaee Fakhr ◽  
Caio Cesar Araujo Morais ◽  
Raffaele Di Fenza ◽  
Grant Larson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Massachusetts General Hospital ◽  
Healthcare Providers ◽  
Severe Pneumonia ◽  
Control Group ◽  
Positive Real ◽  
Research Committee ◽  
Upper Airways ◽  
Scientific Meetings ◽  
Gas Inhalation

AbstractIntroductionIn human hosts, SARS-CoV-2 causes a respiratory syndrome (named COVID-19) which can range from a mild involvement of the upper airways to a severe pneumonia with acute respiratory syndrome that requires mechanical ventilation in an intensive care unit (ICU). Hospital-associated transmission is an important route of spreading for the SARS-CoV-2 virus and healthcare providers are at the highest risk. As of February 2020, 1716, Chinese healthcare workers had confirmed SARS-CoV-2 infections and at least 6 died. Unfortunately, there is currently no vaccine or pharmacological prophylaxis to decrease the risk of healthcare providers contracting the infection.Methods and analysisWe will randomize 470 healthcare providers scheduled to work with COVID 19 patients to receive nitric oxide gas administration (NO group, n=235) or no gas administration (control group, n=235). The primary endpoint of this study is the incidence of subjects with COVID-19 disease at 14 days from enrollment. Secondary endpoints are the proportion of healthcare providers who present a positive real time RT-PCR test for SARS-CoV- 2 14 days after enrollment, the proportion of healthcare providers requiring quarantine, and the total number of quarantine days in the two groups.Ethics and disseminationThe trial protocol is under the approval of The Partners Human Research Committee of Massachusetts General Hospital (Boston, USA) and recruitment is expected to start in April 2020. The results of this study will be published in scientific journals and presented at scientific meetings.

scholarly journals Recent Advances in Predicting Protein S-Nitrosylation Sites

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Qian Zhao ◽  
Jiaqi Ma ◽  
Fang Xie ◽  
Yu Wang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Drug Development ◽  
Posttranslational Modifications ◽  
Essential Role ◽  
Protein S ◽  
Covalent Modification ◽  
Biological Mechanism ◽  
Future Perspectives ◽  
Recent Advances ◽  
Related Drug

Protein S-nitrosylation (SNO) is a process of covalent modification of nitric oxide (NO) and its derivatives and cysteine residues. SNO plays an essential role in reversible posttranslational modifications of proteins. The accurate prediction of SNO sites is crucial in revealing a certain biological mechanism of NO regulation and related drug development. Identification of the sites of SNO in proteins is currently a very hot topic. In this review, we briefly summarize recent advances in computationally identifying SNO sites. The challenges and future perspectives for identifying SNO sites are also discussed. We anticipate that this review will provide insights into research on SNO site prediction.

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