Comparative Binding Energy (COMBINE) Analysis of Human Neutrophil Elastase Inhibition by Pyridone-containing Trifluoromethylketones

2001 ◽  
Vol 4 (8) ◽  
pp. 627-642 ◽  
Author(s):  
Carmen Cuevas ◽  
Manuel Pastor ◽  
Carlos Perez ◽  
Federico Gago
Keyword(s):  
Binding Energy ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Combine Analysis ◽  
Human Neutrophil Elastase ◽  
Comparative Binding

Human neutrophil elastase inhibitory activity of Solanum dulcamara extracts

2006 ◽  
Vol 27 (S 1) ◽  
Author(s):  
K Jenett-Siems ◽  
U Friedrich ◽  
MF Melzig
Keyword(s):  
Inhibitory Activity ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Solanum Dulcamara

scholarly journals Flavonoids as inhibitors of human neutrophil elastase

2021 ◽  
Vol 36 (1) ◽  
pp. 1016-1028
Author(s):  
Katarzyna Jakimiuk ◽  
Jakub Gesek ◽  
Atanas G. Atanasov ◽  
Michał Tomczyk
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase

Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones

1994 ◽  
Vol 37 (26) ◽  
pp. 4538-4553 ◽  
Author(s):  
Michael R. Angelastro ◽  
Larry E. Baugh ◽  
Philippe Bey ◽  
Joseph P. Burkhart ◽  
Teng-Man Chen ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Orally Active

Optimisation of a human neutrophil elastase assay and investigation of the effect of sesquiterpene lactones

Biologicals ◽  
2005 ◽  
Vol 33 (3) ◽  
pp. 175-184 ◽  
Author(s):  
Karin Schorr ◽  
Anita Rott ◽  
FernandoBatista Da Costa ◽  
Irmgard Merfort
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Sesquiterpene Lactones ◽  
Human Neutrophil Elastase

scholarly journals Elastase as a marker for neutrophilic myeloid cells.

1984 ◽  
Vol 32 (4) ◽  
pp. 389-394 ◽  
Author(s):  
J A Kramps ◽  
P van der Valk ◽  
M M van der Sandt ◽  
J Lindeman ◽  
C J Meijer
Keyword(s):  
Cell Lines ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Myeloid Cells ◽  
Hematopoietic Cell ◽  
Human Neutrophil Elastase ◽  
Specific Marker ◽  
Neoplastic Cells ◽  
Myeloproliferative Diseases ◽  
Myelomonocytic Leukemia

The immunohistochemical results obtained with antibodies directed against human neutrophil elastase is described. It was found that neutrophil elastase can be used as a specific marker of cells of the neutrophilic lineage. In normal hematopoietic cell preparations, only promyelocytes and more differentiated myeloid cells stain positive for elastase. In acute or chronic myeloid and myelomonocytic leukemia, the same neutrophil myeloid cells stain positive, whereas neoplastic cells of the monocytoid line are negative. Using elastase in conjunction with other markers, it is possible to differentiate easily the involvement of different cell lines in myeloproliferative diseases.

Synthesis of peptidyl fluoromethyl ketones and peptidyl .alpha.-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

1990 ◽  
Vol 33 (1) ◽  
pp. 394-407 ◽  
Author(s):  
Norton P. Peet ◽  
Joseph P. Burkhart ◽  
Michael R. Angelastro ◽  
Eugene L. Giroux ◽  
Shujaath Mehdi ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Cathepsin G ◽  
Human Neutrophil Elastase ◽  
Pancreatic Elastase ◽  
Keto Esters ◽  
Porcine Pancreatic Elastase

scholarly journals Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels

2009 ◽  
Vol 10 (6) ◽  
pp. 1484-1489 ◽  
Author(s):  
Alex A. Aimetti ◽  
Mark W. Tibbitt ◽  
Kristi S. Anseth
Keyword(s):  
Ethylene Glycol ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

2011 ◽  
Vol 33 (S1) ◽  
pp. E73-E101 ◽  
Author(s):  
Susana D. Lucas ◽  
Elsa Costa ◽  
Rita C. Guedes ◽  
Rui Moreira
Keyword(s):  
Molecular Weight ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Low Molecular Weight ◽  
Human Neutrophil Elastase
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