Solid-phase Bromination and Suzuki Coupling of 2-Carboxyindoles

2001 ◽  
Vol 4 (6) ◽  
pp. 521-524 ◽  
Author(s):  
J. Tois ◽  
R. Franzen ◽  
O. Aitio ◽  
I. Laakso ◽  
J. Huuskonen ◽  
...  
Keyword(s):  
Solid Phase ◽  
Suzuki Coupling

Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling

2011 ◽  
Vol 64 (5) ◽  
pp. 540 ◽  
Author(s):  
Jae Wook Lee ◽  
Hyung-Ho Ha ◽  
Marc Vendrell ◽  
Jacqueline T. Bork ◽  
Young-Tae Chang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Structural Diversity ◽  
Suzuki Coupling ◽  
Purification Step ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Triazine Derivatives ◽  
Polymer Supported

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.

Rapid microwave-assisted Suzuki coupling on solid-phase

1996 ◽  
Vol 37 (45) ◽  
pp. 8219-8222 ◽  
Author(s):  
Mats Larhed ◽  
Gunnar Lindeberg ◽  
Anders Hallberg
Keyword(s):  
Solid Phase ◽  
Suzuki Coupling ◽  
Microwave Assisted

ChemInform Abstract: Rapid Microwave-Assisted Suzuki Coupling on Solid-Phase.

ChemInform ◽  
2010 ◽  
Vol 28 (7) ◽  
pp. no-no ◽  
Author(s):  
M. LARHED ◽  
G. LINDEBERG ◽  
A. HALLBERG
Keyword(s):  
Solid Phase ◽  
Suzuki Coupling ◽  
Microwave Assisted

Suzuki coupling reaction for the solid-phase preparation of 5-substituted nicotinic acid derivatives

2005 ◽  
Vol 46 (4) ◽  
pp. 581-585 ◽  
Author(s):  
Joan-Carles Fernàndez ◽  
Laia Solé-Feu ◽  
Dolors Fernández-Forner ◽  
Natalia de la Figuera ◽  
Pilar Forns ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Solid Phase ◽  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Suzuki Coupling Reaction ◽  
Nicotinic Acid Derivatives

Solid-Phase Suzuki Coupling for C−C Bond Formation

1996 ◽  
Vol 61 (15) ◽  
pp. 5169-5171 ◽  
Author(s):  
Joseph W. Guiles ◽  
Sigmond G. Johnson ◽  
William V. Murray
Keyword(s):  
Solid Phase ◽  
Bond Formation ◽  
Suzuki Coupling

Efficient synthesis of 3-substituted 2-arylindoles via Suzuki coupling reactions on the solid phase

2001 ◽  
Vol 42 (29) ◽  
pp. 4751-4754 ◽  
Author(s):  
Han-Cheng Zhang ◽  
Hong Ye ◽  
Kimberly B White ◽  
Bruce E Maryanoff
Keyword(s):  
Solid Phase ◽  
Suzuki Coupling ◽  
Coupling Reactions ◽  
Efficient Synthesis

scholarly journals Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications

2011 ◽  
Vol 7 ◽  
pp. 1294-1298 ◽  
Author(s):  
Bruno Piqani ◽  
Wei Zhang
Keyword(s):  
Microwave Heating ◽  
Multicomponent Reaction ◽  
High Efficiency ◽  
Solid Phase ◽  
Biginelli Reaction ◽  
Suzuki Coupling ◽  
Atom Economy ◽  
Fast Reaction ◽  
Diversity Oriented Synthesis ◽  
Biginelli Reactions

Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency of the diversity-oriented synthesis is achieved by conducting a multicomponent reaction for improved atom economy, under microwave heating for fast reaction, and with fluorous solid-phase extractions (F-SPE) for ease of purification.

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