Cell-Mediated and Humoral Immune Responses to Bordetella pertussis Inactivated Whole-Cells Encapsulated Alginate Microspheres as a New Vaccine Candidate

2017 ◽  
Vol 18 (7) ◽  
Author(s):  
Naser M. Dounighi ◽  
Fereshteh Shahcheraghi ◽  
Mehdi Razzaghi-Abyaneh ◽  
Mojtaba Nofeli ◽  
Hossein Zolfagharian
Keyword(s):  
Immune Responses ◽  
Bordetella Pertussis ◽  
Vaccine Candidate ◽  
Whole Cells ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Humoral Immune Responses in a Human Case of Glanders

2012 ◽  
Vol 19 (5) ◽  
pp. 814-816 ◽  
Author(s):  
David M. Waag ◽  
Marilyn J. England ◽  
David DeShazer
Keyword(s):  
Immune Responses ◽  
Burkholderia Pseudomallei ◽  
Human Case ◽  
Burkholderia Mallei ◽  
Baseline Serum ◽  
Content Type ◽  
Whole Cells ◽  
Humoral Immune ◽  
Diagnostic Antigen ◽  
Humoral Immune Responses

ABSTRACTWithin 2 months of acquiring glanders, a patient developed 8-, 16-, and 4-fold increases, respectively, in specific IgA, IgG, and IgM serological titers againstBurkholderia mallei. Within 14 months of infection, the titers decreased to the baseline. Serum from this patient was also highly reactive againstBurkholderia pseudomalleiwhole cells.Burkholderia malleiwhole cells did not react with sera from patients with other diseases. Therefore, an assay using aB. malleicellular diagnostic antigen may be useful for the serodiagnosis of glanders.

Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

Cytokine ◽  
2015 ◽  
Vol 74 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Franciele Maira Moreira Batista Tomaz ◽  
Adriana Antônia da Cruz Furini ◽  
Marcela Petrolini Capobianco ◽  
Marinete Marins Póvoa ◽  
Pamella Cristina Alves Trindade ◽  
...  
Keyword(s):  
Immune Responses ◽  
Endemic Area ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Brazilian Amazon ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Vaccine Candidate Antigen ◽  
Malaria Vaccine Candidate ◽  
Candidate Antigen

scholarly journals A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

2020 ◽  
Author(s):  
Di Yin ◽  
Sikai Ling ◽  
Xiaolong Tian ◽  
Yang Li ◽  
Zhijue Xu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Neutralizing Antibodies ◽  
Vaccine Candidate ◽  
Emerging Infectious Diseases ◽  
Innate Immune ◽  
Transduction Efficiency ◽  
Vaccine Platform ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Further Development

ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for which a vaccine is urgently needed to control its spreading. To facilitate the representation of a native-like immunogen without being infectious, here, we reported a SARS-CoV-2 vaccine candidate (designated ShaCoVacc) by incorporating spike-encoding mRNA inside and decorating spike protein on the surface of the virus simulating particles (VSPs) derived from lentiviral particles. We characterized the mRNA copy number, glycosylation status, transduction efficiency, and innate immune property of the new vaccine platform. Importantly, we showed the ShaCoVacc induced strong spike-specific humoral immune responses and potent neutralizing activities by a single injection. Additionally, we disclosed the epitopes of spike-specific antibodies using peptide microarray and revealed epitopes susceptible to specific neutralizing antibodies. These results support further development of ShaCoVacc as a candidate vaccine for COVID-19 and VSP may serve as a new vaccine platform for emerging infectious diseases.

Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649–684, a mucosal subunit HIV/AIDS vaccine candidate

Vaccine ◽  
2006 ◽  
Vol 24 (23) ◽  
pp. 5047-5055 ◽  
Author(s):  
Nobuyuki Matoba ◽  
Brian C. Geyer ◽  
Jacquelyn Kilbourne ◽  
Annette Alfsen ◽  
Morgane Bomsel ◽  
...  
Keyword(s):  
Immune Responses ◽  
Vaccine Candidate ◽  
Humoral Immune ◽  
Aids Vaccine ◽  
Humoral Immune Responses ◽  
Hiv Aids

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization
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