Enhanced Mefenamic Acid Release from Poloxamer-Silicon Dioxide Gel Filled in Hard Gelatin Capsules – An application of Liquid Semisolid Matrix Technology for Insoluble Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Misbah Sultana ◽  
Safia Sultana ◽  
Khalid Hussain ◽  
Tariq Saeed ◽  
Mobashar Ahmad Butt ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Stability Studies ◽  
Gelatin Capsules ◽  
First Order ◽  
Long Term Stability ◽  
First Order Kinetics ◽  
Acid Release ◽  
Model Drug ◽  
Hard Gelatin Capsules

Introduction: : Liquid semisolid matrix (LSSM) technology involves the filling of drug-mixed gel in hard gelatin capsules for different applications. Methods: In continuation of our previous work on LSSM technology, 10% (w/w) of practically insoluble model drug, mefenamic acid was incorporated in gels of different poloxamers with 8% (w/w) SiO2. Gels exhibited plasticity or pseudoplasticity along thixotropy at 2 and 24 h enabling their easy filling into hard gelatin capsules without content seepage. Mefenamic acid gels prepared with L64 and L92 maintained their apparent viscosities for the study period of one month. Around 100% mefenamic acid was released within 90 min from L64- and in 150 min from L92-SiO2 gels, both with first-order kinetics. Results: In 12 month long-term stability studies, only mefenamic acid-L64-SiO gel at 30°C/65% RH indicated dispersion stability with similar rheology and release pattern to that at 2, 24 and 30 days. Conclusion: No chemical drug-polymer interactions were found in FTIR. The release of practically insoluble mefenamic acid could be enhanced from gel formulated with L64 and SiO2.

scholarly journals Long-term stability studies of a semiconductor photoelectrode in three-electrode configuration

2019 ◽  
Vol 7 (48) ◽  
pp. 27612-27619 ◽  
Author(s):  
Srinivas Vanka ◽  
Kai Sun ◽  
Guosong Zeng ◽  
Tuan Anh Pham ◽  
Francesca Maria Toma ◽  
...  
Keyword(s):  
Electrode Configuration ◽  
Stability Studies ◽  
Term Stability ◽  
Long Term Stability

GaN/Si photocathode exhibits an ultrahigh stability of 3000 h under AM 1.5G one-sun illumination.

On the Kinetics Description of Below-Tg Structural Relaxation in Network Glass Formers

2013 ◽  
Vol 200 ◽  
pp. 162-167 ◽  
Author(s):  
Valentina Balitska ◽  
Roman Golovchak ◽  
Oleh Shpotyuk
Keyword(s):  
Structural Relaxation ◽  
Chalcogenide Glasses ◽  
Glassy Matrix ◽  
Physical Ageing ◽  
Exponential Behavior ◽  
First Order ◽  
First Order Kinetics ◽  
Network Glass ◽  
Arsenic Selenides

Phenomenological description of below-Tg structural relaxation known as long-term natural physical ageing in network glass formers exemplified by chalcogenide glasses of binary arsenic selenides was adequately developed within formalism of first-order kinetics. This kinetics was shown to obey a character stretched exponential behavior being treated as sequence of aligning-shrinkage stages throughout glassy matrix.

Modeling effects of system frequency variation in long-term stability studies

1996 ◽  
Vol 11 (2) ◽  
pp. 827-832 ◽  
Author(s):  
R.K. Varma ◽  
R.M. Mathur ◽  
G.J. Rogers ◽  
P. Kundur
Keyword(s):  
Frequency Variation ◽  
Stability Studies ◽  
Term Stability ◽  
Long Term Stability ◽  
System Frequency

scholarly journals Release of selected amino acids from zinc carriers

2016 ◽  
Vol 66 (2) ◽  
pp. 269-277
Author(s):  
Renata Dyja ◽  
Barbara Dolińska ◽  
Florian Ryszka
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Molar Ratio ◽  
Time Intervals ◽  
Solubility In Water ◽  
First Order ◽  
First Order Kinetics ◽  
Acid Release ◽  
Co Precipitation ◽  
Low Solubility

Abstract The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1–4.6 μmol of histidine or 8.7–9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9–11.2 μmol) is limited by the tyrosine low solubility in water.

POLYNOMIAL MAP FACTORIZATION OF SYMPLECTIC MAPS

2003 ◽  
Vol 14 (06) ◽  
pp. 847-854 ◽  
Author(s):  
GOVINDAN RANGARAJAN
Keyword(s):  
Integration Method ◽  
Symplectic Integration ◽  
Stability Studies ◽  
Symplectic Maps ◽  
Long Term Stability ◽  
Polynomial Map ◽  
Symplectic Map ◽  
Integration Algorithms ◽  
Three Degree Of Freedom

Long-term stability studies of nonlinear Hamiltonian systems require symplectic integration algorithms which are both fast and accurate. In this paper, we study a symplectic integration method wherein the symplectic map representing the Hamiltonian system is refactorized using polynomial symplectic maps. This method is analyzed for the three degree of freedom case. Finally, we apply this algorithm to study a large particle storage ring.

scholarly journals Preparation and long term stability studies of carbon dioxide adsorbents based on hyperbranched polymers

Polimery ◽  
2020 ◽  
Vol 65 (03) ◽  
pp. 174-183 ◽  
Author(s):  
Pawel G. Parzuchowski ◽  
Magdalena Mazurek ◽  
Aleksandra Swiderska ◽  
Marlena Roguszewska ◽  
Karolina Rolinska ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Hyperbranched Polymers ◽  
Stability Studies ◽  
Term Stability ◽  
Long Term Stability
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