Memapsin 2 (Beta-Secretase) Inhibitors: Drug Development

2008 ◽  
Vol 5 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Arun Ghosh ◽  
Nagaswamy Kumaragurubaran ◽  
Ling Hong ◽  
Gerald Koelsh ◽  
Jordan Tang
Keyword(s):  
Drug Development ◽  
Beta Secretase ◽  
Memapsin 2

Amyloid‐beta reduction by memapsin 2 (beta‐secretase) immunization

2007 ◽  
Vol 21 (12) ◽  
pp. 3184-3196 ◽  
Author(s):  
Wan‐Pin Chang ◽  
Deborah Downs ◽  
Xiang‐Ping Huang ◽  
Huining Da ◽  
Kar‐Ming Fung ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Beta Secretase ◽  
Memapsin 2

O1-06-03: Memapsin 2 (beta-secretase, BACE) immunization as therapy for Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S20-S21
Author(s):  
Wan-Pin Chang ◽  
Gerald Koelsch ◽  
Deborah Downs ◽  
Kar-Ming Fung ◽  
Huining Da ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Secretase ◽  
Memapsin 2

Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality

2007 ◽  
Vol 4 (4) ◽  
pp. 418-422 ◽  
Author(s):  
Arun Ghosh ◽  
Geoffrey Bilcer ◽  
Lin Hong ◽  
Gerald Koelsch ◽  
Jordan Tang
Keyword(s):  
Secretase Inhibitor ◽  
Beta Secretase ◽  
Memapsin 2 ◽  
Inhibitor Drug

P2-323: Memapsin 2 (beta-secretase, BACE) immunization as specific and safe therapy for Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T467-T467
Author(s):  
Wan-Pin Chang ◽  
Huining Da ◽  
Xiangping Huang ◽  
Deborah Downs ◽  
Kar-Ming Fung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Secretase ◽  
Memapsin 2

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

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