scholarly journals Human aspartic protease memapsin 2 cleaves the beta -secretase site of beta -amyloid precursor protein

2000 ◽  
Vol 97 (4) ◽  
pp. 1456-1460 ◽  
Author(s):  
X. Lin ◽  
G. Koelsch ◽  
S. Wu ◽  
D. Downs ◽  
A. Dashti ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Beta Secretase ◽  
Memapsin 2

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

Structural Features of Human Memapsin 2 (β-Secretase) and their Biological and Pathological Implications

2004 ◽  
Vol 36 (12) ◽  
pp. 787-792 ◽  
Author(s):  
Lin Hong ◽  
Xiangyuan He ◽  
Xiangping Huang ◽  
Wanpin Chang ◽  
Jordan Tang
Keyword(s):  
Amyloid Precursor Protein ◽  
Transmembrane Domain ◽  
Amyloid Β ◽  
Structural Features ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
The Past ◽  
Memapsin 2 ◽  
Β Amyloid ◽  
Major Target

Abstract Memapsin 2 (β-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of β-amyloid precursor protein (APP) leading to the production of amyloid-β (Aβ), a major factor in the pathogenesis of Alzheimer's disease (AD). Since memapsin 2 is a major target for the development of inhibitor drugs for AD, it has been intensively studied during the past five years. Here we discuss the structural features of the catalytic/specificity apparatus, transmembrane domain, cytosolic domain and the implications of these features in the physiological and pathological roles of this protease.

scholarly journals The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

1990 ◽  
Vol 265 (16) ◽  
pp. 8983-8985 ◽  
Author(s):  
S Sinha ◽  
H F Dovey ◽  
P Seubert ◽  
P J Ward ◽  
R W Blacher ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein
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