On the Origins of Hepatitis C Virus NS5B Polymerase Inhibitory Activity Using Machine Learning Approaches

2015 ◽  
Vol 15 (18) ◽  
pp. 1814-1826 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Veda Prachayasittikul ◽  
Nuttapat Anuwongcharoen ◽  
Watshara Shoombuatong ◽  
Virapong Prachayasittikul ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Inhibitory Activity ◽  
Learning Approaches ◽  
Ns5b Polymerase

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

2016 ◽  
Vol 17 (13) ◽  
pp. 1560-1576 ◽  
Author(s):  
Yuanchao Xie ◽  
Comfort Alicha Ogah ◽  
Xiangrui Jiang ◽  
Jianfeng Li ◽  
Jingshan Shen
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nucleoside Inhibitors ◽  
Ns5b Polymerase

The discovery and structure–activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase

2010 ◽  
Vol 20 (9) ◽  
pp. 2968-2973 ◽  
Author(s):  
Matthew G. LaPorte ◽  
Tandy L. Draper ◽  
Lori E. Miller ◽  
Charles W. Blackledge ◽  
Lara K. Leister ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Ns5b Polymerase

Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase

2005 ◽  
Vol 48 (14) ◽  
pp. 4547-4557 ◽  
Author(s):  
Steven Harper ◽  
Salvatore Avolio ◽  
Barbara Pacini ◽  
Marcello Di Filippo ◽  
Sergio Altamura ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Hepatitis C Virus Rna ◽  
Allosteric Inhibitors ◽  
Virus Rna ◽  
Ns5b Polymerase

Phosphoramidate Dinucleosides as Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

2011 ◽  
Vol 90 (2) ◽  
pp. A75
Author(s):  
S. Priet ◽  
I. Zlatev ◽  
I. Barvik ◽  
J. Neyts ◽  
H. Dutartre ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Polymerase Activity ◽  
Subgenomic Replicon ◽  
Ns5b Polymerase

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements

2013 ◽  
Vol 91 (1) ◽  
pp. 66-81 ◽  
Author(s):  
Pierre L. Beaulieu ◽  
René Coulombe ◽  
James Gillard ◽  
Christian Brochu ◽  
Jianmin Duan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Carboxylic Acid ◽  
Allosteric Inhibitors ◽  
Subgenomic Replicon ◽  
Structure Activity ◽  
Hcv Ns5b ◽  
Acid Function ◽  
Ns5b Polymerase

Acylsulfonamide and acylsulfamide as surrogates for the carboxylic acid function of N-acetamide-indole-6-carboxylic acids were evaluated as allosteric inhibitors of hepatitis C virus (HCV) NS5B polymerase. Several analogs displayed excellent antiviral potency against both 1a and 1b HCV genotypes in cell-based subgenomic replicon assays. Structure–activity relationships (SAR) are discussed in the context of the crystal structure of an inhibitor − NS5B polymerase complex. Absorption, distribution, metabolism, and excretion pharmacokinetic (ADME-PK) properties of this class of inhibitors are also described.

Syntheses of nucleosides with 2′-spirolactam and 2′-spiropyrrolidine moieties as potential inhibitors of hepatitis C virus NS5B polymerase

2014 ◽  
Vol 55 (28) ◽  
pp. 3813-3816 ◽  
Author(s):  
Qun Dang ◽  
Zhibo Zhang ◽  
Bingyu Tang ◽  
Yang Song ◽  
Ling Wu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Potential Inhibitors ◽  
Ns5b Polymerase

3D-QSAR and molecular docking studies on designing inhibitors of the hepatitis C virus NS5B polymerase

2016 ◽  
Vol 1117 ◽  
pp. 227-239 ◽  
Author(s):  
Wenlian Li ◽  
Hongzong Si ◽  
Yang Li ◽  
Cuizhu Ge ◽  
Fucheng Song ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
3D Qsar ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Ns5b Polymerase
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