Synthesis and DFT Study on Hantzsch Reaction to Produce Asymmetrical Compounds of 1,4-Dihydropyridine Derivatives for P-Glycoprotein Inhibition as Anticancer Agent

2018 ◽  
Vol 13 (2) ◽  
pp. 255-264 ◽  
Author(s):  
Shirin Mollazadeh ◽  
Fatemeh Moosavi ◽  
Farzin Hadizadeh ◽  
Mahmoud Seifi ◽  
Javad Behravan ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Dft Study ◽  
Hantzsch Reaction ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition ◽  
Dihydropyridine Derivatives

Synthesis and In vitro P-Glycoprotein Inhibitory Activity of Novel 1,4-Dihydropyridine Derivatives

2014 ◽  
Vol 7 (3) ◽  
pp. 2544-2552
Author(s):  
Sirisha Kalam ◽  
Rajyalaxmi I ◽  
Olivia S
Keyword(s):  
Microwave Irradiation ◽  
Spectral Data ◽  
Inhibitory Activity ◽  
Hantzsch Reaction ◽  
P Glycoprotein ◽  
Dihydropyridine Derivatives ◽  
Mdr Reversal

Two series of new symmetrical 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl/heteroaryl)-carbamoyl-1,4-dihydropyridines (4a-f) and asymmetrical 4-aryl-2,6-dimethyl-3-N-(aryl/hetero-aryl)-carbamoyl-5-ethyl carboxylate-1,4-dihydro-pyridines (5a-f) have been synthesized by simple, economical and eco-friendly, modified Hantzsch reaction using                               N-aryl/heteroarylacetoacetamides (3a-c), ethylaceto-acetate (for asymmetric),  arylaldehydes and urea in presence of catalytic amounts of LiBr/Iodine and by microwave irradiation methods. The newly synthesized compounds were characterized by physical and spectral data, and evaluated for their possible in vitro MDR reversal activity by everted sac method using verapamil as standard P-gp inhibitor and domperidone as the standard P-gp substrate. Amongst the compounds tested, compound 4f exhibited the highest in vitro P-gp inhibitory activity. It was found to be more potent than the standard verapamil.  

Clinical evaluation of P-glycoprotein inhibition by venetoclax: a drug interaction study with digoxin

Xenobiotica ◽  
2017 ◽  
Vol 48 (9) ◽  
pp. 904-910 ◽  
Author(s):  
Manoj S. Chiney ◽  
Rajeev M. Menon ◽  
Orlando F. Bueno ◽  
Bo Tong ◽  
Ahmed Hamed Salem
Keyword(s):  
Drug Interaction ◽  
Clinical Evaluation ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition

99mTc-Sestamibi, A Sensitive Probe for In Vivo Imaging of P-Glycoprotein Inhibition by Modulators and mdr1 Antisense Oligodeoxynucleotides

2006 ◽  
Vol 8 (6) ◽  
pp. 333-339 ◽  
Author(s):  
Veronika Jekerle ◽  
Jing-Hung Wang ◽  
Deborah A. Scollard ◽  
Raymond M. Reilly ◽  
Michael Wiese ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Antisense Oligodeoxynucleotides ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition ◽  
99Mtc Sestamibi

In vitro and in silico evaluation of P-glycoprotein inhibition through 99m Tc-methoxyisobutylisonitrile uptake

2018 ◽  
Vol 93 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Seyed Sajad Hosseini Balef ◽  
Majid Piramoon ◽  
Seyed Jalal Hosseinimehr ◽  
Hamid Irannejad
Keyword(s):  
In Silico ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition

Effect of treatment period with LC478, a disubstituted adamantayl derivative, on P-glycoprotein inhibition: its application to increase docetaxel absorption in rats

Xenobiotica ◽  
2019 ◽  
Vol 50 (7) ◽  
pp. 863-874
Author(s):  
Seung Yon Han ◽  
Eun-Sun Kim ◽  
Byoung Hoon You ◽  
Hee-Sung Chae ◽  
Qili Lu ◽  
...  
Keyword(s):  
Treatment Period ◽  
P Glycoprotein ◽  
Effect Of Treatment ◽  
Glycoprotein Inhibition
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