In Situ Gelling Ophthalmic Drug Delivery System: An Overview and Its Applications

2015 ◽  
Vol 9 (3) ◽  
pp. 242-253 ◽  
Author(s):  
Ravi Sheshala ◽  
Yong Kok ◽  
Jun Ng ◽  
Raghu Thakur ◽  
Kamal Dua
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

Effect of carrageenan and potassium chloride on an in situ gelling ophthalmic drug delivery system based on methylcellulose

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60386-60391 ◽  
Author(s):  
Biplab Bhowmick ◽  
Gunjan Sarkar ◽  
Dipak Rana ◽  
Indranil Roy ◽  
Nayan Ranjan Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potassium Chloride ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Model Drug ◽  
In Situ Gelling ◽  
Ophthalmic Formulation

Our research is devoted to developing a methylcellulose (MC) basedin situgelling ophthalmic formulation using pilocarpine hydrochloride as a model drug, containing different proportions of i (iota)-carrageenan and potassium chloride.

scholarly journals Research progress of in-situ gelling ophthalmic drug delivery system

2019 ◽  
Vol 14 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Yumei Wu ◽  
Yuanyuan Liu ◽  
Xinyue Li ◽  
Dereje Kebebe ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
In Situ Gelling

scholarly journals pH Triggered In-situ Gelling Ophthalmic Drug Delivery System

2018 ◽  
Vol 8 (01) ◽  
Author(s):  
Kurniawansyah I S ◽  
Rahmi F ◽  
Sopyan I
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Eye Drops ◽  
Ophthalmic Drug Delivery ◽  
Short Period ◽  
Ophthalmic Drug ◽  
In Situ Gelling

Eyes are delicate and most vital organs of the body whose defence mechanism restricts entry of exogenous substance. Conventional drug delivery systems get washed off within a short period of time that usually cause poor bioavailability and therapeutic responses because high tear fluid turnover and dynamics cause rapid elimination of the drug from the eye. In-situ gelling ophthalmic drug delivery system is one of the new methods that is developed to overcome this bioavailability problems. In-situ gelling systems are viscous polymerbased liquids that exhibit sol-to-gel phase transition on the ocular surface due to a change in a specific physicochemical parameter like temperature, ionic strength, or pH triggered in-situ systems. Using this formulation of pH triggered in-situ gel systems, the release of drug can be sustained for longer periods of time, therapeutically more efficacious, non-irritant and stable than conventional eye drops.

Modified PLA nano in situ gel: A potential ophthalmic drug delivery system

2011 ◽  
Vol 86 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Ramesh C. Nagarwal ◽  
Rakesh Kumar ◽  
M. Dhanawat ◽  
J.K. Pandit
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug
Sign in / Sign up

Export Citation Format

Share Document