Corrigendum: Inhibitory Effect of Codeine on Sucrase Activity

2021 ◽  
Vol 14 (3) ◽  
pp. 232-232
Author(s):  
Dariush Minai-Tehrani ◽  
Saeed Minoui ◽  
Marzie Sepehre ◽  
Zohre Sharif-Khodai ◽  
Tooka Aavani
Keyword(s):  
Drug Metabolism ◽  
Inhibitory Effect ◽  
Typographical Error ◽  
Sucrase Activity ◽  
Fourth Author

A typographical error appeared in the author’s name of the article entitled “Inhibitory Effect of Codeine on Sucrase Activity“ by Dariush Minai-Tehrani, Saeed Minoui, Marzie Sepehre, Zohre Sharif-Khodai, Tooka Aavani, Drug Metabolism Letters, 2009; 3(1): 58-60. [1]. Details of the error and a correction are provided here. The fourth author#039;s name in this article was misspelled. Hence it should be read as "Zohreh Sharifkhodaei" as per the request of the author. We regret the error and apologize to readers. The original article can be found online at: https://www.eurekaselect.com/93132/article Original: Zohre Sharif-Khodai Corrected: Zohreh Sharifkhodaei

Lack of inhibitory effect of wood creosote on cytochrome P450‐mediated drug metabolism

2021 ◽  
Author(s):  
Hirokazu Chokki ◽  
Yuki Nishimura ◽  
Mariko Iwase ◽  
Norimitsu Kurata ◽  
Koichiro Shinya ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Inhibitory Effect ◽  
Wood Creosote

scholarly journals Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity

2006 ◽  
Vol 95 (5) ◽  
pp. 933-938 ◽  
Author(s):  
Tsuneyuki Oku ◽  
Mai Yamada ◽  
Mariko Nakamura ◽  
Naoki Sadamori ◽  
Sadako Nakamura
Keyword(s):  
Brush Border Membrane ◽  
Sucrose Solution ◽  
Membrane Vesicles ◽  
Inhibitory Effect ◽  
Morus Alba ◽  
Inhibitory Effects ◽  
Sucrase Activity ◽  
Inhibitory Activities ◽  
Small Intestinal ◽  
Fasted Rats

The inhibitory effect on human and rat intestinal disaccharidase by the extractive from the leaves ofMorus alba (ELM) containing 0·24% 1-deoxynojirimycin equivalent and its inhibitory activities were investigated by the modified Dahlqvist method. In the presence of 1000-fold diluted ELM solution, the sucrase activity of four human samples was inhibited by 96% and that of maltase and isomaltase by 95 and 99 %, respectively. The activities of trehalase and lactase were inhibited by 44 and 38 %, respectively. The human disaccharidase activities varied from sample to sample because the samples were obtained from different resected regions after surgery. However, the ratio of the inhibitory effect for sucrase, maltase, isomaltase, trehalase and lactase was very similar among the four samples, and also that of resembled rat intestinal disaccharides. The inhibitory constant of the 1-deoxynojirimycin equivalent for sucrase, maltase and isomaltase was 2·1× 10−4, 2·5 × 10−4 and 4·5 10−4μM, respectively, and these inhibitory activities were shown, using rat brush border membrane vesicles, to be competitive. These results demonstrate that digestion is inhibited when an appropriate amount of ELM is orally ingested with sucrose or polysaccharide in man. When ELM was orally administered in a sucrose solution to fasted rats, the elevation in blood glucose was significantly suppressed, depending on the concentration of ELM given. These results suggest that ELM could be used as an ingredient in health foods and in foods that help to prevent diabetes.

Inhibitory effect of tranylcypromine on hepatic drug metabolism in the rat

1982 ◽  
Vol 31 (16) ◽  
pp. 2679-2683 ◽  
Author(s):  
Pierre-M. Bélanger ◽  
Ameyo Atitsé-Gbeassor
Keyword(s):  
Drug Metabolism ◽  
Inhibitory Effect ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

Inhibitory Effect of Codeine on Sucrase Activity

2009 ◽  
Vol 3 (1) ◽  
pp. 58-60 ◽  
Author(s):  
Dariush Minai-Tehrani ◽  
Saeed Minoui ◽  
Marzie Sepehre ◽  
Zohre Sharif-Khodai ◽  
Tooka Aavani
Keyword(s):  
Inhibitory Effect ◽  
Sucrase Activity

scholarly journals The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Lingti Kong ◽  
Chunli Song ◽  
Linhu Ye ◽  
Daohua Guo ◽  
Meiling Yu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Ischemic Stroke ◽  
Drug Metabolism ◽  
Human Liver ◽  
Dose Adjustment ◽  
Biological Activities ◽  
Liver Microsomes ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Human Cytochrome

Vinpocetine is a derivative of the alkaloid vincamine, which had been prescribed for chronic cerebral vascular ischemia and acute ischemic stroke or used as a dietary supplement for its several different mechanisms of biological activities. However, information on the cytochrome P450 (CYP) enzyme-mediated drug metabolism has not been previously studied. The present study was performed to investigate the effects of vinpocetine on CYPs activity, and cocktail method was used, respectively. To evaluate the effects of vinpocetine on the activity of human CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, human liver microsomes were utilized to incubate with the mixed CYPs probe substrates and the target components. The results indicate that vinpocetine exhibited weak inhibitory effect on the CYP2C9, where the IC50value is 68.96 μM, whereas the IC50values for CYP3A4, CYP2C19, CYP2D6, and CYP2E1 were all over range of 100 μM, which showed that vinpocetine had no apparent inhibitory effects on these CYPs. In conclusion, the results indicated that drugs metabolized by CYP2C9 coadministrated with vinpocetine may require attention or dose adjustment.

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