scholarly journals Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage

2009 ◽  
Vol 3 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Yan-Ping Huang ◽  
Yong-Ping Zheng
Keyword(s):  
Articular Cartilage ◽  
Intravascular Ultrasound ◽  
High Frequency ◽  
Quantitative Assessment ◽  
The Body ◽  
High Frequency Ultrasound ◽  
Surface Reflection ◽  
Before And After ◽  
Highly Correlated

Conventional ultrasound examination of the articular cartilage performed externally on the body surface around the joint has limited accuracy due to the inadequacy in frequency used. In contrast to this, minimally invasive arthroscopy-based ultrasound with adequately high frequency may be a better alternative to assess the cartilage. Up to date, no special ultrasound transducer for imaging the cartilage in arthroscopic use has been designed. In this study, we introduced the intravascular ultrasound (IVUS) for this purpose. An IVUS system with a catheter-based probe (Ø ≈ 1mm) was used to measure the thickness and surface acoustical reflection of the bovine patellar articular cartilage in vitro before and after degeneration induced by enzyme treatments. Similar measurement was performed using another high frequency ultrasound system (Vevo) with a probe of much larger size and the results were compared between the two systems. The thickness measured using IVUS was highly correlated (r = 0.985, p < 0.001) with that obtained by Vevo. Thickness and surface reflection amplitude measured using IVUS on the enzymatically digested articular cartilage showed changes similar to those obtained by Vevo, which were expectedly consistent with previous investigations. IVUS can be potentially used for the quantitative assessment of articular cartilage, with its ready-to-use arthroscopic feature.

3-D High-Frequency Ultrasound Backscatter Analysis of Human Articular Cartilage

2014 ◽  
Vol 40 (1) ◽  
pp. 244-257 ◽  
Author(s):  
Nils Männicke ◽  
Martin Schöne ◽  
Matthias Gottwald ◽  
Felix Göbel ◽  
Michael L. Oelze ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
High Frequency ◽  
Human Articular Cartilage ◽  
High Frequency Ultrasound ◽  
Ultrasound Backscatter ◽  
Frequency Ultrasound

In vitro and in vivo high‐frequency ultrasound response of microbubbles

2006 ◽  
Vol 119 (5) ◽  
pp. 3438-3438
Author(s):  
Orlando Aristizábal ◽  
Daniel H. Turnbull ◽  
Jeffrey A. Ketterling
Keyword(s):  
High Frequency ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound

In vitro study of a multi-layer piezoelectric crystal attic hearing implant

2001 ◽  
Vol 115 (5) ◽  
pp. 359-362 ◽  
Author(s):  
R. P. Mills ◽  
Z. G. Wang ◽  
E. W. Abel
Keyword(s):  
High Frequency ◽  
In Vitro Study ◽  
Ossicular Chain ◽  
The Body ◽  
Laser Vibrometer ◽  
Optimal Method ◽  
Low Frequencies ◽  
Series Of Experiments ◽  
Multilayer Piezoelectric Actuator

We have developed a prototype middle-ear hearing implant which uses a multilayer piezoelectric actuator. In this series of experiments the actuator was attached to the medial wall of the attic so that it makes contact with the body of the incus. Initial in vitro evaluation has been carried out using a laser vibrometer (Polytec CLV) to measure stapes velocity. Stapes displacement is calculated by mathematical integration. The device used in this way is particularly effective at transmitting high frequency sound to the stapes. When switched off the actuator impairs the transmission of sound to the ossicular chain at low frequencies, but this effect is only 7 dB at most. The stapes displacements resulting from the action of the implant have a linear relationship with the voltages used to drive the system. The high capacitance of the present actuator means that its power requirements are higher than that of other comparable devices. An optimal method of coupling the device to the incus has yet to be identified.

scholarly journals Optimization of subharmonic generation from ultrasound contrast agents at high frequency ultrasound

2021 ◽  
Author(s):  
Sara Iradji
Keyword(s):  
Contrast Agents ◽  
High Frequency ◽  
Ultrasound Contrast Agents ◽  
Surrounding Tissue ◽  
High Frequency Ultrasound ◽  
High Frequencies ◽  
Ultrasound Contrast ◽  
Wide Range ◽  
Frequency Ultrasound

The microcirculation can be differentiated from the surrounding tissue using high frequency ultrasound subharmonic imaging. This imaging technique relies on the detection of energy scattered from ultrasound contrast agents at half the transmit frequency due to their resonant oscillations. The current contrast agents and the subharmonic imaging parameters have not been optimized for high frequencies. Moreover, the origin of subharmonic generation from submicron bubbles is not well-understood. The size distribution of Definity™ phospholipid-shelled microbubbles was altered to find the optimal bubble size to be resonant over a wide range of high frequencies. The resonant behaviour of bubbles was investigated through in vitro attenuation measurements. The transmit frequency and pressure were varied to optimize the backscattered subharmonic signal. Alteration of Definity™ population significanatly improved the scattering for subharmonic imaging at 20 MHz. A peak negative pressure between 400 to 600 kPa is suggested for this frequency range.

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