Nanomaterials for Spinal Cord Injury Recovery

Abstract Spinal cord injury has been described in only 2% to 5% of electrical injuries. When its presentation is delayed for several days to weeks after the initial injury, recovery is not the rule. Herein, we describe two patients who developed spinal cord injury from electrical burns. Case 1: A 60-year-old male presented with a 40% TBSA after contacting a power line. On hospital day 6, he developed lower extremity weakness that progressed to flaccid paralysis. Case 2: A 58-year-old male sustained a 9% TBSA high-voltage injury. On hospital day 2, he started to have progressive weakness of his lower extremities that progressed to flaccid paralysis. Neither case was judged to have experienced additional significant trauma. Neurological complications after electrical injuries are protean. Delayed spinal cord injury is rare and associated with variable degrees of recovery. Neurological follow-up with rehabilitation is essential for a successful recovery.

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Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery

Neural Regeneration Research ◽

10.4103/1673-5374.165520 ◽

2015 ◽

Vol 10 (9) ◽

pp. 1477 ◽

Cited By ~ 3

Author(s):

Rui Gu ◽

Chuan-gang Peng ◽

Shu-quan Zhang ◽

Min-fei Wu ◽

Yang Lv ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Schwann Cell ◽

Cell Transplantation ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Cord Injury ◽

Injury Recovery

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Honeysuckle Extract Plays a Protective Role in Spinal Cord Injury Recovery by Regulating PI3K/Akt Signaling Pathway

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.20:135-140 ◽

2021 ◽

Vol 20 (1) ◽

pp. 135-140

Author(s):

Hongjuan Cheng ◽

Guopeng You ◽

Haoyu Dong ◽

Jie Wei ◽

Luran Yang

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Traumatic Injury ◽

Protective Role ◽

Neural Function ◽

Akt Signaling Pathway ◽

Cord Injury ◽

Function Loss ◽

Cellular Apoptosis ◽

Injury Recovery

Spinal cord injury (SCI) is a traumatic injury leading to hypoxia, lipid peroxidation, and cellular apoptosis. Honeysuckle (Lonicera japonicae) has been used to treat headaches and play a neuroprotective role. However, its possible effects on protection from neurological function loss during injury remain to be explored. To this end, we have investigated the effects of honeysuckle extract on neural function injury in SCI rats and report an improvement in nerve function. The mechanism involved reduced expression of proinflammatory cytokines, decrease in cellular apoptosis, and activation of PI3K/Akt pathway. We conclude that possible use of honeysuckle extract for treatment of SCI needs further exploration.

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