Avaliação do Uso do Lactobacillus reuteri em Pacientes Portadores da Síndrome de Supercrescimento Bacteriano Diagnosticados por Teste Respiratório / Evaluation of the Use of Lactobacillus reuteri in Patients with Bacterial Overgrowth Syndrome Diagnosed

1970 ◽  
Vol 3 (2) ◽  
pp. 5-17
Author(s):  
Juliana Totti De Souza ◽  
Jussara Coelho Rosa ◽  
Thalita Amaral Amaro Adami
Keyword(s):  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Lactobacillus Reuteri ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Test Methods ◽  
Overgrowth Syndrome ◽  
Abdominal Symptoms ◽  
Irritable Bowel

Objetivo: Avaliar a ação de probiótico constituído pelo Lactobacillus reuteri em pacientes selecionados como portadores da síndrome do supercrescimento bacteriano do intestino delgado (SSCBID), através do teste respiratório da lactulose. Métodos: Foram incluídos 21 pacientes que apresentavam sintomas gastrointestinais inespecíficos, mas sugestivos de SSCBID. Foram selecionados através do questionário específico, para serem submetidos ao teste respiratório para lactulose. Os indivíduos com teste positivo foram convocados para iniciarem tratamento com probiótico composto por 100.000.000 UFC de Lactobacillus reuteri por quatro semanas e posterior reavaliação dos sintomas. Resultados: O resultado do teste respiratório foi positivo em 13 (61,90%) participantes (p=0,0391). A principal queixa foi a dor e/ou desconforto abdominal, com 46,15% (6/13) dos casos. A síndrome do intestino irritável representou o diagnóstico prévio de 30,77% (4/13) dos casos. 9 dos 13 pacientes tratados (69,23%) obtiveram melhora do quadro clínico inicial com o uso do probiótico. Conclusão: As evidências indicam que novos estudos devem ser realizados sobre os probióticos, para que sua aplicação clínica na síndrome do supercrescimento bacteriano seja definida. Neste estudo, o probiótico reduziu a sintomatologia abdominal em pacientes com SSCBID, com impacto na qualidade de vida destes indivíduos.  Palavras chave: supercrescimento bacteriano, teste respiratório, síndrome do intestino irritável, probióticos.   ABSTRACT Objective: To assess the efficacy of probiotic Lactobacillus reuteri made by patients selected as having syndrome of small intestinal bacterial overgrowth (SSCBID) through the lactulose breath test. Methods: We included 21 patients who had nonspecific gastrointestinal symptoms, but suggestive of SSCBID, who were selected through specific questionnaire to be submitted to the breath test lactulose. Individuals with a positive test were called for starting treatment with probiotic composed of Lactobacillus reuteri UFC 100 million for four weeks and subsequent reassessment of symptoms. Results: The results of the breath test was positive in 13 (61.90%) participants (p=0.0391). The main complaint was pain and/or abdominal discomfort, with 46.15% (6/13) of cases. The irritable bowel syndrome represented the previous diagnosis of 30.77% (4/13) of cases. Nine out of the 13 patients (69.23%) had clinical improvement starting with the use of probiotics. Conclusion: Evidence indicates that further studies should be conducted on probiotics, so its clinical application in bacterial overgrowth syndrome is defined. In this study, the probiotic reduced abdominal symptoms in patients with SSCBID, with impact on the quality of life of these individuals.  Keywords: bacterial overgrowth, breath test, irritable bowel syndrome, probiotics.

scholarly journals Irritable bowel syndrome and small intestinal bacterial overgrowth: Assessment with breath test

2020 ◽  
pp. 041-048
Author(s):  
LA Costa ◽  
TNF Gomes ◽  
CU Braga ◽  
L Lenz ◽  
SJ Miszputen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Diagnostic Methods ◽  
Intestinal Bacterial Overgrowth ◽  
Exhaled Air ◽  
Baseline Values ◽  
Small Intestinal ◽  
Irritable Bowel

Background: Irritable bowel syndrome (IBS) has been considered a functional disease, however evidences suggest organic abnormalities as disbiosis. The aim of this study was to evaluate bacterial overgrowth syndrome in IBS patients. Methods: Patients with IBS were submited to the expired H2 and CH4 breath test, with analyzes of exhaled air in fasting (zero minutes) and after the administration of 10g of lactulose, at times: 15, 30, 60, 90, 120, 150 and 180 minutes. The test was considered positive when the values of H2 or CH4 at 90 minutes were 20 ppm above baseline values. Results: Fourth-six patients were included, 23 (50%) had diarrheal subtype, 12 (26.1%) had constipated subtype and 11 (23.9%) had mixed subtype. All patients were submitted to lactulose breath test (LBT), with evaluation of expired H2 and CH4. The H2 test positivity was 15.2% and the CH4 test was 10.9%. In the diarrheal subgroup, the positivity of the H2 test was 13%, and at the CH4 test was 8.7%. Among the constipated patients, 16.7% were positive for H2 test, and none was positive for CH4 test. At the mixed subtype, the H2 test was positive for 18.2% and CH4 test for 27.3%. There was no significant correlation between the positivity of expired H2 test with the diarrheal subtype, and neither the expired CH4 test with the constipated subtype. Conclusion: LBT has not altered in patients with three forms of IBS. The optimization of diagnostic methods is necessary for a more accurate diagnosis.

scholarly journals Small intestinal bacterial overgrowth is associated with intestinal inflammation in the irritable bowel syndrome

2014 ◽  
Vol 87 (3) ◽  
pp. 163-165 ◽  
Author(s):  
Liliana David ◽  
Alexandru Babin ◽  
Alina Picos ◽  
Dan Lucian Dumitrascu
Keyword(s):  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Intestinal Inflammation ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal ◽  
Glucose Breath Test ◽  
Irritable Bowel ◽  
Low Degrees

Background and aim. Small intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal bacterial overgrowth in irritable bowel syndrome.Methods. Small intestinal bacterial overgrowth was assessed by the H2 glucose breath test in 90 consecutive patients with irritable bowel syndrome. A check-up of the oral cavity was carried out before the breath testing.  Further on, the patients were classified into two groups, positive and negative, at the breath test. Then they were tested for intestinal inflammation with a fecal test for calprotectin. We used a semiquantitative test for this study. Both groups were compared for the association of intestinal inflammation with small intestinal bacterial overgrowth.Results. A number of 24/90 (26.7%) patients with irritable bowel syndrome had small intestinal bacterial overgrowth. A positive test for intestinal inflammation was significantly more frequent in patients with irritable bowel syndrome and small intestinal bacterial overgrowth (chi2: p<0.05).Conclusions. Small intestinal bacterial overgrowth is present in almost one quarter of patients with irritable bowel syndrome. It is significantly associated with intestinal inflammation.

scholarly journals ANALYSIS OF LACTOSE INTOLERANCE IN STUDENTS WITH SUGGESTIVE SYMPTOMS OF IRRITABLE BOWEL SYNDROME

2019 ◽  
Vol 56 (3) ◽  
pp. 304-311
Author(s):  
Cleise de Jesus SILVA ◽  
Ingrid Dantas Sampaio LEITE ◽  
José Weberton RODRIGUES ◽  
Samara Pereira de ALMEIDA ◽  
Bruna Pessoa NÓBREGA ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Gastrointestinal Symptom ◽  
Lactose Intolerance ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Irritable Bowel ◽  
Carbohydrate Intolerance

ABSTRACT BACKGROUND: Irritable bowel syndrome is a clinical condition presenting pain, distension and abdominal fullness, diarrhea, constipation, and other symptoms. It generates significant impacts on the quality of life of those affected. The pathophysiology is uncertain, but the role of various food types has been established in bowel sensitivity and its clinical manifestations. Carbohydrate intolerance, particularly to lactose, generates similar and sometimes indistinguishable symptoms from irritable bowel syndrome, and in clinical practice is both a frequent and underdiagnosed condition. Carbohydrate intolerance is related to enzymatic deficiencies, alterations of intestinal microbiota and even genetic change. The principal test for a diagnosis of lactose intolerance is the breath test, which measures hydrogen emission (produced only by bacteria), after ingestion of the corresponding substrate. OBJECTIVE: The present work aims to verify the prevalence of lactose intolerance in university students, presenting gastrointestinal symptoms suggestive of irritable bowel syndrome. METHODS: In a transversal study, to screen for those with suggestive symptoms, 124 medicine students participated by responding to a form. Those with abdominal pain were referred for anti-parasite treatment in order to exclude intestinal parasites as a secondary cause. Subsequently, using the hydrogen breath test, bacterial overgrowth was investigated, and if negative, lactose intolerance testing would be performed. Patients presenting high hydrogen concentrations of ≥20 ppm above the basal level were considered lactose intolerant. RESULTS: Of the total of students researched (n=124), 7 were excluded because they did not completing all study phases. From those 117 individuals effectively included in the survey; 8 (6.8%) were diagnosed with lactose intolerance and 2 (1.7%) with bacterial overgrowth. Intolerance was more frequent in; female individuals (75%), age range 18 to 25 years (62.5%), being colored (50%), and in their 5th semester of studies (37.5%). The presence of at least one gastrointestinal symptom among those presenting intolerance (100%), and those not presenting intolerance (42.2%) was found (P=0.002). In addition to abdominal pain (100%) (P<0.001), the most recurrent gastrointestinal symptom in the lactose intolerant students was the distension/flatulence (62.5%) (P=0.026). In relation to life habits and food patterns, there was no statistical difference between lactose tolerant and intolerant individuals, or for symptom frequencies. The more advanced students, completing more periods towards graduation, demonstrated more occurrences of gastrointestinal symptoms, yet without presenting significant statistical discrepancies. CONCLUSION: In view of the test sample quantity (n=21), a high prevalence of lactose intolerance (6.8%) in the academic environment, with epidemiological characteristics compatible to those found the literature is demonstrated, generating knowledge with understanding to prevent, diagnose, alleviate and treat lactose intolerant university students, and generate positive impacts towards well-being, improving the quality of life of these individuals.

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