Effects of Internet-delivered Cognitive Behavioral Therapy in Patients with Irritable Bowel Syndrome: Meta-Analysis (Preprint)

2021 ◽  
Author(s):  
Hyunjung Kim ◽  
Younjae Oh ◽  
Sun Ju Chang

BACKGROUND Irritable bowel syndrome is a common functional gastrointestinal disorder that negatively affects all aspects of life. With the widespread use of the Internet, internet-delivered cognitive behavioral therapy has been developed and applied to control symptoms and improve the quality of life of those with irritable bowel syndrome. OBJECTIVE This study aimed to systematically review studies that examined the use of internet-delivered cognitive behavioral therapy in patients with irritable bowel syndrome and to evaluate the effects of internet-delivered cognitive behavioral therapy on the improvement of symptom severity, quality of life, and psychological status, and on cost-effectiveness. METHODS This meta-analysis involved the search of six databases for relevant publications. Nine randomized controlled trials were finally included in the analysis. RESULTS Internet-delivered cognitive behavioral therapy had medium to large effects (standardized mean difference, 95% confidence interval) on symptom severity (-0.633; -0.861 to -0.4304), quality of life (0.582; 0.396 to 0.769), and cost-effectiveness (-0.372; -0.704 to -0.039) at post-intervention, and the effects on symptom severity remained over time even after the intervention. There was no significant difference in psychological status, including anxiety and depression, in those with irritable bowel syndrome compared to the controls during the post-intervention period. CONCLUSIONS This review demonstrated that internet-delivered cognitive behavioral therapy could be a cost-effective intervention for improving symptoms and the quality of life in patients with irritable bowel syndrome. However, studies are still insufficient regarding the use of internet-delivered cognitive behavioral therapy in these patients; therefore, more high-quality studies are required in future.

2021 ◽  
Author(s):  
Sanam Borji-Navan ◽  
Sakineh Mohammad-Alizadeh-Charandabi ◽  
Khalil Esmaeilpour ◽  
Mojgan Mirghafourvand ◽  
Ali Ahmadian-Khooinarood

Abstract Background: Premenstrual Syndrome (PMS) is a common problem among women of reproductive age, affecting various aspects of their lives. There are very limited studies investigating the effect of Internet-Based Cognitive-Behavioral Therapy (ICBT) on PMS. We aimed to investigate the effect of ICBT on symptom severity of women suffering from PMS and their quality of life in the perimenstrual and late follicular periods. Methods: Ninety-two university students aged 18-35 years with moderate to severe PMS were allocated into two groups of 46 using block randomization. The intervention group underwent ICBT for two menstrual cycles, while the control group received no intervention. All participants filled the Daily Record of Severity of Problems (DRSP) for two menstrual cycles and the Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF) on days 1-2 and 11-13 of the menstrual cycle pre- and post-intervention. Data were analyzed using univariate general linear models. Results: Four students in the intervention group were lost to follow-up. Post-interventionally, the mean score of total PMS symptoms was significantly lower in the intervention group than the control group (10.4 vs. 20.2, adjusted difference: -9.9 [95% CI: -13.3 to -6.6]) and perimenstrual quality of life was significantly higher (64.2 vs. 50.3, 14.1 [8.5 to 19.8]). However, there was no significant intergroup difference in the late follicular quality of life (68.3 vs. 67.3, 1.9 [-4.4 to 8.1]). Conclusions: Internet-Based Cognitive-Behavioral Therapy could effectively reduce PMS symptom severity and improve perimenstrual quality of life, with no significant effect on the late follicular quality of life. Trial registration: The Iranian Registry of Clinical Trials, Identifier: IRCT20100414003706N34, Registered 19 June 2019, https://www.irct.ir/trial/38394


2016 ◽  
Vol 25 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Teodora Surdea-Blaga ◽  
Adriana Baban ◽  
Laurentiu Nedelcu ◽  
Dan L. Dumitrascu

Irritable bowel syndrome (IBS) patients often present psychoform symptoms or psychiatric disorders. Among the psychological factors studied in IBS patients, two seem to influence mostly its severity: catastrophizing and somatization. Somatization is an independent risk factor for IBS. In addition, somatization more than the severity of IBS influences the way the patients perceive their illness, the outcome and the efficacy of treatment. Irritable bowel syndrome patients demonstrate greater catastrophizing scores than controls, and pain catastrophizing is a significant predictor of gastrointestinal symptoms related to pain. In this context we analysed the data regarding the efficacy of two psychological treatments in IBS: cognitive behavioral therapy and hypnosis. Cognitive behavioral therapy is focused on replacing maladaptive coping strategies with more positive cognitions and behaviors. Several studies showed that cognitive behavioral therapy is effective in reducing bowel symptoms in IBS, both post-treatment and short-term follow-up. Gut-directed hypnotherapy has beneficial short-term effects in improving gastrointestinal symptoms of patients with IBS, and the results are maintained after one year in half of the patients. Psychological treatments are a suitable option for selected IBS patients. Abbreviations: CBT: Cognitive Behavioral Therapy; FGIDs: functional gastrointestinal disorders; GDH: Gut-Directed Hypnotherapy; GI: gastrointestinal; HRQoL: health related quality of liffe; IBS: irritable bowel syndrome; ICBT: Internet-delivered CBT; ISM: Internet-delivered Stress Management; NNT: number needed to treat; PROs: Patient-reported outcomes; QoL: Quality of Life; SD: Somatization Disorders; SMT: Supportive Medical Treatment.


2021 ◽  
Author(s):  
Sanam Borji-Navan ◽  
Sakineh Mohammad-Alizadeh-Charandabi ◽  
Khalil Esmaeilpour ◽  
Mojgan Mirghafourvand ◽  
Ali Ahmadian-Khooinarood

Abstract Background: Premenstrual Syndrome (PMS) is a common problem among women of reproductive age, affecting various aspects of their lives. There are very limited studies investigating the effect of Internet-Based Cognitive-Behavioral Therapy (ICBT) on PMS. We aimed to investigate the effect of ICBT on symptom severity of women suffering from PMS and their quality of life in the perimenstrual and late follicular periods. Methods: Ninety-two university students aged 18-35 years with moderate to severe PMS were allocated into two groups of 46 using block randomization. The intervention group underwent ICBT for two menstrual cycles, while the control group received no intervention. All participants filled the Daily Record of Severity of Problems (DRSP) for two menstrual cycles and the Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF) on days 1-2 and 11-13 of the menstrual cycle pre- and post-intervention. Data were analyzed using univariate general linear models. Results: Four students in the intervention group were lost to follow-up. Post-interventionally, the mean score of total PMS symptoms was significantly lower in the intervention group than the control group (10.4 vs. 20.2, adjusted difference: -9.9 [95% CI: -13.3 to -6.6]) and perimenstrual quality of life was significantly higher (64.2 vs. 50.3, 14.1 [8.5 to 19.8]). However, there was no significant intergroup difference in the late follicular quality of life (68.3 vs. 67.3, 1.9 [-4.4 to 8.1]). Conclusions: Internet-Based Cognitive-Behavioral Therapy could effectively reduce PMS symptom severity and improve perimenstrual quality of life, with no significant effect on the late follicular quality of life. Trial registration: The Iranian Registry of Clinical Trials, Identifier: IRCT20100414003706N34, Registered 19 June 2019, https://www.irct.ir/trial/38394


EP Europace ◽  
2016 ◽  
Vol 18 (suppl_1) ◽  
pp. i30-i30
Author(s):  
Helga Skúladóttir ◽  
Särnholm Josefin ◽  
Christian Rück ◽  
Susanne Pedersen ◽  
Ljótsson Brjánn ◽  
...  

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Shosha H. M. Peersmann ◽  
Annemieke van Straten ◽  
Gertjan J. L. Kaspers ◽  
Adriana Thano ◽  
Esther van den Bergh ◽  
...  

Abstract Background Adolescents and young adults who had childhood cancer are at increased risk for insomnia, due to being critically ill during an important phase of their life for the development of good sleep habits. Insomnia is disabling and prevalent after childhood cancer (26–29%) and negatively impacts quality of life, fatigue, pain, and general functioning and is often associated with other (mental) health problems. Insomnia and a history of childhood cancer both increase the risk of adverse health outcomes, posing a double burden for adolescents who had childhood cancer. The first-line treatment for insomnia is cognitive behavioral therapy for insomnia (CBT-I). However, access to this type of care is often limited. The guided online CBT-I treatment “i-Sleep” has been developed to facilitate access via online care. i-Sleep is shown effective in adult (breast cancer) patients, but it is unknown if iCBT-I is effective in pediatric oncology. Methods/design We developed a youth version of i-Sleep. Our aim is to evaluate its effectiveness in a national randomized-controlled clinical trial comparing iCBT-I to a waiting-list control condition at 3 and 6 months (n = 70). The intervention group will be also assessed at 12 months to see whether the post-test effects are maintained. Adolescents and young adults aged 12–30 years with insomnia, diagnosed with (childhood) cancer, currently at least 6 months since their last cancer treatment will be eligible. Outcomes include sleep efficiency (actigraphic), insomnia severity (self-report), sleep and circadian activity rhythm parameters, fatigue, health-related quality of life, perceived cognitive functioning, chronic distress, depressive and anxiety symptoms, and intervention acceptability. Discussion Insomnia is prevalent in the pediatric oncology population posing a double health burden for adolescents and young adults who had childhood cancer. If guided iCBT-I is effective, guidelines for insomnia can be installed to treat insomnia and potentially improve quality of life and the health of adolescents and young adults who had childhood cancer. Trial registration NL7220 (NTR7419; Netherlands Trial register). Registered on 2 August 2018


2012 ◽  
Vol 1 ◽  
pp. 123-129 ◽  
Author(s):  
Majid Mahvi-Shirazi ◽  
Ali Fathi-Ashtiani ◽  
Sayed-Kazem Rasoolzade-Tabatabaei ◽  
Mohsen Amini

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