scholarly journals Sizzling Issues in Clinical Renal TransplantationTransplant nephrectomy improves survival following a failed renal allograft. J Am Soc Nephrol 21: 324–380, 2010The success of continued steroid avoidance after kidney transplantation in the US. Am J Transplant 9: 2768–2776, 2009Factors associated with progression of interstitial fibrosis in renal transplant patients receiving tacrolimus and mycophenolate mofetil. Transplantation 88: 897–903, 2009

2010 ◽  
Vol 5 (2) ◽  
pp. 169-172 ◽  
Author(s):  
Mario F. Rubin ◽  
JC Ayus ◽  
JD Schold ◽  
DN Rush ◽  
SG Achinger ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplantation ◽  
Renal Transplant ◽  
Renal Allograft ◽  
Interstitial Fibrosis ◽  
Transplant Patients ◽  
The Us ◽  
Renal Transplant Patients ◽  
Steroid Avoidance

Factors Associated With Progression of Interstitial Fibrosis in Renal Transplant Patients Receiving Tacrolimus and Mycophenolate Mofetil

2009 ◽  
Vol 88 (7) ◽  
pp. 897-903 ◽  
Author(s):  
David N. Rush ◽  
Sandra M. Cockfield ◽  
Peter W. Nickerson ◽  
Dianne J. Arlen ◽  
Anne Boucher ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Interstitial Fibrosis ◽  
Factors Associated ◽  
Transplant Patients ◽  
Renal Transplant Patients

A direct association of polyomavirus BK viruria with deterioration of renal allograft function in renal transplant patients

2009 ◽  
Vol 23 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Yi-Jung Li ◽  
Yung-Chang Chen ◽  
Ping-Chin Lai ◽  
Ji-Tseng Fang ◽  
Chih-Wei Yang ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Allograft ◽  
Transplant Patients ◽  
Direct Association ◽  
Allograft Function ◽  
Polyomavirus Bk ◽  
Renal Transplant Patients

Long-Term Study of Steroid Avoidance in Renal Transplant Patients: A Single-Center Experience

2015 ◽  
Vol 47 (4) ◽  
pp. 1099-1104 ◽  
Author(s):  
A.M. Nagib ◽  
M.H. Abbas ◽  
M.M. Abu-Elmagd ◽  
A.A.E.F. Denewar ◽  
A.H. Neamatalla ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Single Center ◽  
Term Study ◽  
Transplant Patients ◽  
Single Center Experience ◽  
Long Term Study ◽  
Renal Transplant Patients ◽  
Steroid Avoidance

Differential influence of azathioprine and mycophenolate mofetil on the disposition of basiliximab in renal transplant patients

2001 ◽  
Vol 15 (2) ◽  
pp. 123-130 ◽  
Author(s):  
John M Kovarik ◽  
Mark D Pescovitz ◽  
Hans W Sollinger ◽  
Bruce Kaplan ◽  
Christophe Legendre ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients

Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients

2004 ◽  
Vol 107 (1) ◽  
pp. 63-68 ◽  
Author(s):  
David GOLDSMITH ◽  
Elizabeth A. CARREY ◽  
Stephen EDBURY ◽  
Ryszard T. SMOLENSKI ◽  
Piotr. JAGODZINSKI ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Plasma Metabolites ◽  
Renal Transplant Recipients ◽  
Inosine Monophosphate Dehydrogenase ◽  
Inosine Monophosphate ◽  
Transplant Patients ◽  
Renal Transplant Patients ◽  
Monophosphate Dehydrogenase

The immunosuppressant MMF (mycophenolate mofetil) has increasingly replaced AZA (azathioprine) in renal transplantation. MMF is a prodrug of MPA (mycophenolic acid), which inhibits lymphocyte IMPDH (inosine monophosphate dehydrogenase), thereby drastically decreasing GTP concentrations essential to lymphocyte proliferation in vitro and in vivo. Erythrocyte GTP concentrations are commonly elevated in severe renal disease, but normalize following successful engraftment. Consequently, elevated GTP in renal transplant recipients might signal impending loss of immunosuppression and graft failure. In the present study, we compared erythrocyte nucleotides and plasma metabolites in two groups of 25 patients after renal transplantation, both receiving prednisolone and cyclosporin A, but one group receiving MMF and the other AZA. No patients had recent allograft biopsy evidence of rejection. Erythrocyte GTP concentrations at MMF commencement were 50.4±23.4 μmol/l. An increase occurred during the first 3 months after transplant when MMF was used de novo, stabilizing at 146.7±62.9 μmol/l after 4 months. This was significantly higher (P=2.5×10−6) than erythrocyte GTP (40.4±15.9 μmol/l) in the AZA group, which was essentially unchanged from values immediately after successful transplantation. The effect of MMF on erythrocyte GTP levels was reversible, since GTP levels fell when MMF therapy was terminated. The results demonstrate paradoxically high GTP concentrations in erythrocytes of renal transplant patients receiving MMF. MPA may stabilize reticulocyte IMPDH, allowing the protein to persist during erythropoiesis. This behaviour is in marked contrast with the decrease in GTP levels seen in white blood cells of patients on chronic MMF therapy.

Mycophenolate Mofetil Initiation in Renal Transplant Patients at Different Times Posttransplantation: The TranCept Switch Study

2011 ◽  
Vol 91 (9) ◽  
pp. 984-990 ◽  
Author(s):  
Herwig-Ulf Meier-Kriesche ◽  
Pierre Merville ◽  
Helio Tedesco-Silva ◽  
Uwe Heemann ◽  
Petar Kes ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Transplant Patients ◽  
Renal Transplant Patients ◽  
Switch Study
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