Abstract::
Triple negative breast cancer present aggressive form of breast cancer subtype which further lacks efficient
treatment strategies and prognostic markers. Genomic heterogeneity in TNBC has led to the relapse of tumor and cancer
stem cells with higher likelihood of distal metastasis. Several studies supported the notion that miRNAs may act as oncogene
or tumor suppressors in TNBC. miRNAs may function as global regulator of TNBC by targeting post transcriptional
regulation of several genes involved in influencing metastatic events but the exact mechanism involved in inducing the effect
is yet to be elucidated. In this review, we summarized miRNA expression which can functionally suppress metastatic
cascade in TNBC by targeting epithelial to mesenchymal transition, metastatic colonization, cancer stem cells, invasion, migration
and metastasis. miRNAs may appear as metastatic biomarker to predict distal reoccurrence of TNBC in lungs, brain
and lymph nodes. miRNA can act as prognostic marker in metastatic TNBC thereby predicting overall survival, disease free
survival and distant metastasis free survival in affected patients. The present review article is an attempt to gain an insight
into repertoire of miRNA that may emerged out as an effective treatment strategy, novel biomarker of distal reoccurrence
and prognostic marker in metastatic TNBC.
Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer