Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction

2021 ◽  
Author(s):  
Jishou Zhang ◽  
Yao Xu ◽  
Wen Ding ◽  
Mengmeng Zhao ◽  
Jianfang Liu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
T Lymphocytes ◽  
Ischemic Cardiomyopathy ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Separate Study ◽  
Coronary Artery Diseases ◽  
Plaque Vulnerability

Background: The expression and clinical significance of IL-20 in coronary artery diseases need to be analyzed. Methods: IL-20 and its receptors were analyzed in coronary artery tissues. In a separate study, plasma IL-20 was also evaluated. Results: IL-20 and its receptors were significantly higher in coronary artery stenosis tissues from ischemic cardiomyopathy patients than that from controls. T lymphocytes and macrophages were the main source of IL-20 and expressed its receptors abundantly. Plasma IL-20 was significantly higher in acute myocardial infarction patients than that in controls. Conclusion: IL-20 was closely associated with the presence of acute myocardial infarction. IL-20 may participate in the progression of coronary artery stenosis and plaque vulnerability via regulating T lymphocytes and macrophages.

scholarly journals Intracoronary cavitation as a cause of plaque rupture and thrombosis propagation in patients with acute myocardial infarction: A computational study

2019 ◽  
Vol 7 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Gianluca Rigatelli ◽  
Marco Zuin ◽  
Tra T. Ngo ◽  
Hung T. Nguyen ◽  
Aravinda Nanjundappa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Turbulent Flow ◽  
Coronary Artery Stenosis ◽  
Plaque Rupture ◽  
Computational Study ◽  
Fluid Pressure ◽  
Artery Stenosis

Abstract Background and Objectives Significant rather than moderate coronary artery stenosis has been postulated to be the main substrate of plaque rupture in acute myocardial infarction (AMI). We evaluate if cavitation could influence the coronary artery plaque rupture contributing to the progression of thrombotic process. Methods We reconstructed a 3D model of the left anterior descending coronary artery (LAD) after reviewing the intravascular ultrasound (IVUS) data of 30 consecutive patients with mild to severe coronary artery disease. Results Turbulent flow or cavitation occurs in both concentric and eccentric coronary artery stenosis (≥ 75% for the former and ≥ 50% for the latter). The analysis of vapor phase demonstrated that cavitation propagated downstream, creating microbubbles, which exploded when the fluid pressure was lower than the vapor pressure at a local thermodynamic state. The relative higher vorticity magnitude (as turbulent flow in vivo angiogram) observed on the distal cap of the atherosclerotic plaque created a higher turbulence, probably able to destabilize the plaque through a micro-erosion process. Conclusions Cavitation seems to be able to promote the thrombotic occlusion within the coronary vessels due the ‘constant injuries’ created by the micro-explosion of bubbles.

Acute Myocardial Infarction Due to Fixed Coronary Artery Stenosis From Myocardial Bridging

2020 ◽  
Vol 21 (11) ◽  
pp. 91-93
Author(s):  
Bassim El-Sabawi ◽  
Ilya S. Shadrin ◽  
Gurpreet S. Sandhu ◽  
Juan A. Crestanello ◽  
Allan S. Jaffe
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Myocardial Bridging
Sign in / Sign up

Export Citation Format

Share Document