scholarly journals Real-world treatment patterns among patients with unresected stage III non-small-cell lung cancer

2019 ◽  
Vol 15 (25) ◽  
pp. 2943-2953 ◽  
Author(s):  
Kellie J Ryan ◽  
Karen E Skinner ◽  
Ancilla W Fernandes ◽  
Rajeshwari S Punekar ◽  
Melissa Pavilack ◽  
...  

Aim: Little is known about recent treatment patterns among patients with unresected stage III NSCLC in the real world. This retrospective study used medical records from USA community oncology practices to address this knowledge gap. Materials & methods: Eligible patients were stage III NSCLC adults diagnosed between 1 January 2011 and 1 March 2016 without surgical resection. Treatment patterns were assessed across three progression intervals, from stage III diagnosis through third progression. Results: The most common regimen in interval 1 was platinum doublet chemotherapy + radiation therapy, in interval 2 was chemotherapy only, and in interval 3 was non-platinum chemotherapy monotherapy. Conclusion: Most patients were treated following national guidelines, but important unmet needs remain.

2020 ◽  
Author(s):  
Junji Lin ◽  
Lynn McRoy ◽  
Maxine D Fisher ◽  
Nan Hu ◽  
Cralen Davis ◽  
...  

Background: Limited studies have evaluated palbociclib-based therapy use in patients with advanced/metastatic breast cancer in the real world. This retrospective study used medical records from US community oncology practices to address the gap. Materials & methods: Eligible patients receiving palbociclib-based therapy per label indication from 3 February 2015 to 31 December 2017 were included. Descriptive analyses were conducted for patient characteristics, treatment patterns and clinical outcomes. Results: The study included 233 patients who received palbociclib + aromatase inhibitor (P+AI) and 48 who received palbociclib + fulvestrant (P+F). Real-world progression-free rate for P+AI was 69.8% (46.8%) at 12 (24) months (P+F: 43.5% [39.9%]) months. Real-world survival rate was 89.8% (71.4%) at 12 (24) months (P+F: 76.3% [65.0%]). Conclusion: The study findings are consistent with previous studies of palbociclib-based therapy.


2021 ◽  
Vol 16 (3) ◽  
pp. S284
Author(s):  
L. Kathmann ◽  
J. Roeper ◽  
K. Wedeken ◽  
K. Willborn ◽  
F. Griesinger

2019 ◽  
Vol 14 (8) ◽  
pp. 1430-1439 ◽  
Author(s):  
Sara Moore ◽  
Bonnie Leung ◽  
Jonn Wu ◽  
Cheryl Ho

2020 ◽  
Vol 31 ◽  
pp. S807-S808
Author(s):  
S. Kuang ◽  
M. Liu ◽  
C. Ho ◽  
E. Berthelet ◽  
J. Laskin ◽  
...  

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