Risk factors associated with hypersensitivity reactions to cetuximab: anti-cetuximab IgE detection as screening test

AbstractThis study aimed to investigate risk factors associated with oxaliplatin hypersensitivity reactions in cancer patients through a meta-analysis. A comprehensive retrieve of Chinese databases China National Knowledge Infrastructure, Wanfang Data, VIP Database and English databases PubMed, ScienceDirect, Embase and Cochrane library was conducted. The studies that meet the requirements for meta-analysis according to inclusion and exclusion criteria were screened and assessed for eligibility. Odds ratio (OR) / Weighted mean difference (WMD) and 95% confidence intervals (95% CIs) or calculable dichotomous and continuous raw data were extracted to perform meta-analysis using random effect model or fixed effect model on the basis of heterogeneity between studies through Review Manager 5.4 software. A total of 14 cross-sectional studies and 3367 cancer patients were included. Meta-analysis results showed that platinum exposure history (OR value 3.13, 95% CI 2.19–4.48, heterogeneity P = 0.26), allergy history (OR value 1.76, 95% CI 1.09–2.85, heterogeneity P = 0.61), platinum free interval (OR value 3.75, 95% CI 2.00–7.06, heterogeneity P = 0.83), dexamethasone premedication dose (OR value 0.28, 95% CI 0.13–0.58, heterogeneity P = 0.21) were significantly correlated to oxaliplatin hypersensitivity reactions. Gender, age, metastasis, combination with bevacizumab, XELOX regimen and cancer types were detected to have no statistically significant effect on oxaliplatin hypersensitivity reactions. Platinum exposure history, allergy history and long platinum-free interval are risk factors of oxaliplatin hypersensitivity reactions. High dexamethasone premedication dose is a protective factor of oxaliplatin hypersensitivity reactions.

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SEROPREVALENCE OF TOXOPLASMOSIS IN WOMEN IN MYMENSINGH AND RANGPUR IN BANGLADESH: A HOSPITAL SURVEY

Bangladesh Journal of Veterinary Medicine ◽

10.3329/bjvm.v15i1.34060 ◽

2017 ◽

Vol 15 (1) ◽

pp. 81-85

Author(s):

U. H. Margia ◽

N. Begum ◽

M. S. Hossain ◽

A. R. Dey ◽

M. Z. Alam

Keyword(s):

Risk Factors ◽

Pregnant Women ◽

Screening Test ◽

Human Species ◽

Major Health ◽

Factors Associated ◽

Igm Antibodies ◽

Regular Screening ◽

Health Significance

Toxoplasmosis is a great zoonotic threat that affects human species specially women. It has got major health significance because it causes abortion in pregnant women. The aim of this study was to determine seroprevalence of toxoplasmosis in women in Mymensingh and Rangpur in Bangladesh and to identify possible risk factors associated with toxoplasmosis. In this study, 87 women of 15 to 45 years old were included. Among 87 women, 74.7% (n = 65) were seronegative and 25.3% were (n=22) seropositive for T. gondii IgG and IgM antibodies. However, seroprevalence was higher in women aged between 31-45years. Relationship between T. gondii antibody and pregnancy was found significant (p<0.05). This study also reveals that pregnant women are more susceptible to toxoplasmosis than non-pregnant women. Thusly, regular screening test for toxoplasmosis is necessary for pregnant women in Bangladesh.

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Incidence of and risk factors associated with nedaplatin-related hypersensitivity reactions

International Journal of Clinical Oncology ◽

10.1007/s10147-017-1091-4 ◽

2017 ◽

Vol 22 (3) ◽

pp. 593-599 ◽

Cited By ~ 2

Author(s):

Yuki Kawarada ◽

Masayuki Miyazaki ◽

Ayaka Itoh ◽

Risa Araki ◽

Hidetaka Iwamizu ◽

...

Keyword(s):

Risk Factors ◽

Hypersensitivity Reactions ◽

Factors Associated

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Incidence and Risk Factors of Immediate Hypersensitivity Reactions and Immunisation Stress-related Responses with COVID-19 mRNA Vaccine

10.1101/2022.01.12.22269134 ◽

2022 ◽

Author(s):

Kazuo Imai ◽

Fumika Tanaka ◽

Shuichi Kawano ◽

Kotoba Esaki ◽

Junko Arakawa ◽

...

Keyword(s):

Risk Factors ◽

Vasovagal Syncope ◽

Conditional Logistic Regression ◽

Incidence Rates ◽

Thyroid Diseases ◽

Mass Vaccination ◽

Hypersensitivity Reactions ◽

Immediate Hypersensitivity ◽

Factors Associated ◽

History Of

Background: With the implementation of mass vaccination campaigns against COVID 19, the safety of vaccine needs to be evaluated. Objective: We aimed to assess the incidence and risk factors for immediate hypersensitivity reactions (IHSR) and immunisation stress related responses (ISRR) with the Moderna COVID 19 vaccine. Methods: This nested case control study included recipients who received the Moderna vaccine at a mass vaccination centre, Japan. Recipients with IHSR and ISRR were designated as cases 1 and 2, respectively. Controls 1 and 2 were selected from recipients without IHSR or ISRR and matched (1:4) with cases 1 and cases 2, respectively. Conditional logistic regression analysis was used to identify risk factors associated with IHSR and ISRR. Results: Of the 614,151 vaccine recipients who received 1,201,688 vaccine doses, 306 recipients (cases 1) and 2,478 recipients (cases 2) showed 318 events of IHSR and 2,558 events of ISRR, respectively. The incidence rates per million doses were estimated as IHSR: 266 cases, ISRR: 2,129 cases, anaphylaxis: 2 cases, and vasovagal syncope: 72 cases. Risk factors associated with IHSR included female, asthma, atopic dermatitis, thyroid diseases, and history of allergy; for ISRR, they were younger age, female, asthma, thyroid diseases, mental disorders, and a history of allergy and vasovagal reflex. Conclusion: In the mass vaccination settings, the Moderna vaccine can be used safely owing to the low incidence rates of IHSR and anaphylaxis. However, providers should beware of the occurrence of ISRR. Risk factor identification may contribute to the stratification of high risk recipients for IHSR and ISRR.

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Risk factors associated with substance use

PsycEXTRA Dataset ◽

10.1037/e553882014-001 ◽

2014 ◽

Author(s):

Ariel M. Barber ◽

Alexandra Crouch ◽

Stephen Campbell

Keyword(s):

Risk Factors ◽

Substance Use ◽

Factors Associated

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A Six Year Prospective Study of Fibrinogen and Other Risk Factors Associated with Mortality in Stable Claudicants

Thrombosis and Haemostasis ◽

10.1055/s-0038-1656361 ◽

1992 ◽

Vol 68 (03) ◽

pp. 261-263 ◽

Cited By ~ 71

Author(s):

A K Banerjee ◽

J Pearson ◽

E L Gilliland ◽

D Goss ◽

J D Lewis ◽

...

Keyword(s):

Risk Factors ◽

Intermittent Claudication ◽

Fibrinogen Level ◽

Past History ◽

Fold Increase ◽

Arterial Disease ◽

Plasma Fibrinogen ◽

Plasma Fibrinogen Level ◽

Factors Associated ◽

Probability Of Death

SummaryA total of 333 patients with stable intermittent claudication at recruitment were followed up for 6 years to determine risk factors associated with subsequent mortality. Cardiovascular diseases were the underlying cause of death in 78% of the 114 patients who died. The strongest independent predictor of death during the follow-up period was the plasma fibrinogen level, an increase of 1 g/l being associated with a nearly two-fold increase in the probability of death within the next 6 years. Age, low ankle/brachial pressure index and a past history of myocardial infarction also increased the probability of death during the study period. The plasma fibrinogen level is a valuable index of those patients with stable intermittent claudication at high risk of early mortality. The results also provide further evidence for the involvement of fibrinogen in the pathogenesis of arterial disease.

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