A Review on Mouth Dissolving Film

Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved .Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films. Keywords: Mouth dissolving film, solvent casting, fast disintegration

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Formulation and Evaluation of Fast Dissolving Oral Film of Imipramine

Polytechnic Journal ◽

10.25156/ptj.v10n1y2020.pp182-188 ◽

2020 ◽

Vol 10 (1) ◽

pp. 182-188

Author(s):

Rozhan A. Muhammed ◽

Huner K. Omer

Keyword(s):

Dosage Form ◽

Methyl Cellulose ◽

Petri Dish ◽

Water Soluble ◽

Dissolution Time ◽

Solvent Casting ◽

Casting Method ◽

Water Soluble Polymers ◽

Soluble Polymers ◽

Solid Dosage

Fast dissolving oral film is a new emerging solid dosage form in which it consists of thin strips administered orally and dissolved in mouth within the seconds. The study is purposed to use water soluble polymers to provide rapid film disintegration as the films are hydrated in mouth and to find the best polymer type and its concentration to formulate the drug. Initially, placebo films were prepared using solvent casting method then two formulations from the prepared placebo films were selected to formulate imipramine. The excipients were dissolved in water then the drug solution was prepared by dissolving 150 mg of drug in 5 ml of water then mixed with the excipients and they were mixed gently and casted in disposable Petri dishes and left for 24 h in oven to provide film dryness. Then, the films removed from Petri dish and cut to 2 cm × 2 cm small strips. Then, the tests were performed. Successful films were prepared by 45% hydroxypropyl methyl cellulose (HPMC) and 50% sodium carboxymethyl cellulose (NaCMC). The films were smooth, easily removed from Petri dish without tearing and homogenous. The thin films were mechanically stable that they could be handled without breaking due to their good folding endurance which was more than 400. The pH of the films was accepted since they were around saliva pH (5.3–6.9). The films disintegration time was <60 min since water-soluble polymers were used and this property provided rapid drug release from the formulation in which it was 15–20 min for both of the drug-containing films, while dissolution time for the imipramine conventional tablet was about 60 min. Imipramine can be formulated as a new dosage form (fast dissolving film) using 45% HPMC and 50% NaCMC as polymer using solvent casting method to ease the drug administration for psychotic and pediatric patients since no water is required for this solid dosage for administration.

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Stability studies of hydralazine hydrochloride orodispersible formulations

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i1.1788 ◽

2020 ◽

Vol 11 (1) ◽

pp. 75-86

Author(s):

Muthukumar ◽

Sundaraganapathy R ◽

Sankar C ◽

Sundaramoorthy C ◽

Yuvaraja K R

Keyword(s):

Thin Films ◽

Age Groups ◽

Direct Compression ◽

Solvent Casting ◽

Compression Method ◽

Casting Method ◽

Onset Of Action ◽

Solid Dosage ◽

Sublimation Method ◽

Hydralazine Hydrochloride

Solid dosage forms also have a impervious difficulties in patients especially for geriatric and paediatric patients.Dysphagia is common among all age groups. Orodispersible formulations (Fast dissolving tablets & Fast dissolving oral thin films) constitute an inventive dosage form that overcome the problems swallowing and provides speedy onset of action. The objective of present study was to formulate orodispersible formulations of Hydralazine HCL by different methods (Direct compression method, Sublimation method and solvent casting method). Based on physiochemical evaluations F9 (Direct compression method),SF9 (Sublimation method) for Fast dissolving tablets and H2 formulations (Solvent casting method) for Fast dissolving oral thin films were found optimized formula.The optimized formula were kept for stability under long term, accelerated and intermediate conditions for the study period of six months as per ICH guidelines.Based on stability reports the H2 formulations (Fast dissolving oral thin films) got a better drug release than Fast dissolving tablets.

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