scholarly journals Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease

2021 ◽  
Vol 31 (1) ◽  
pp. 54-63
Author(s):  
K. V. Ivashkin ◽  
V. R. Grechishnikova ◽  
M. S. Reshetova ◽  
V. T. Ivashkin
Keyword(s):  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Immune System Activation ◽  
Peripheral Mechanism ◽  
Key Points ◽  
System Activation ◽  
Small Intestinal ◽  
Quantitative Changes ◽  
Irritable Bowel ◽  
Nonspecific Inflammation

Aim. Assessment of the irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth syndrome (SIBO) interlinkage.Key points. SIBO may represent a "peripheral" mechanism of IBS, aside to nonspecific inflammation, increased epithelial permeability and local immune system activation. In various assays, the SIBO rate in IBS patients was 4-46% vs. 0-13% in an intact cohort. A limited diagnosability of SIBO obscures the SIBO-IBS causal interplay. Impaired motility in IBS may predispose to the SIBO development. Proinflammatory cytokines and mediators in SIBO, in turn, provoke visceral hypersensitivity and intense motility, the key IBS factors. Both conditions relate to qualitative and quantitative changes in microbiota, which warrants the application of probiotic Lactobacillus and Bifidobacterium strains.Conclusion. Further research into the SIBO-IBS interface is required for developing optimal probiotic-based therapies.

M1333 Irritable Bowel Syndrome and the Association With Small Intestinal Bacterial Overgrowth: Putting the Concept in Perspective

2010 ◽  
Vol 138 (5) ◽  
pp. S-382
Author(s):  
Savio Reddymasu ◽  
Bejnamin Alsop ◽  
Tuba Esfandyari ◽  
Melissa M. Oropeza-Vail ◽  
Sandra L. Sostarich ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal ◽  
Irritable Bowel

scholarly journals The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders

2020 ◽  
Vol 21 (10) ◽  
pp. 3531 ◽  
Author(s):  
Giuseppe Losurdo ◽  
Fulvio Salvatore D’Abramo ◽  
Giuseppe Indellicati ◽  
Chiara Lillo ◽  
Enzo Ierardi ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Calcium Deficiency ◽  
Watery Diarrhea ◽  
Irritable Bowel Disease ◽  
Intestinal Bacterial Overgrowth ◽  
History Of ◽  
Small Intestinal ◽  
Irritable Bowel

Small intestinal bacterial overgrowth (SIBO) is a condition hallmarked by an increase in the concentration of colonic-type bacteria in the small bowel. Watery diarrhea, bloating, abdominal pain and distension are the most common clinical manifestations. Additionally, malnutrition and vitamin (B12, D, A, and E) as well as minerals (iron and calcium) deficiency may be present. SIBO may mask or worsen the history of some diseases (celiac disease, irritable bowel disease), may be more common in some extra-intestinal disorders (scleroderma, obesity), or could even represent a pathogenetic link with some diseases, in which a perturbation of intestinal microbiota may be involved. On these bases, we performed a review to explore the multiple links between SIBO and digestive and extra-intestinal diseases.

Sign in / Sign up

Export Citation Format

Share Document