scholarly journals Possibilities of applying pharmacological stress testing in assessment of heart functional capacity in dogs

2010 ◽  
Vol 64 (3-4) ◽  
pp. 287-296
Author(s):  
Ljubica Kosic-Spasojevic ◽  
Dragisa Trailovic
Keyword(s):  
Functional Capacity ◽  
Stress Testing ◽  
Stress Test ◽  
Body Burden ◽  
The Body ◽  
Moderate Physical Activity ◽  
Clinical Implementation ◽  
Pharmacological Stress ◽  
Dobutamine Stress Test ◽  
Pharmacological Stress Testing

Systolic and diastolic heart functions, evaluated using echocardiography, do not reflect the functional capacity of the patient and they cannot explain the occurrence of symptoms during a certain degree of activity. Evaluation of the functional capacity is an integral part of cardiological examinations in human medicine. Functional examinations of the heart can be carried out using the body burden test or pharmacologically. Investigations carried out so far into canine cardiology have not contributed to the clinical implementation of functional heart examinations in dogs. Pharmacological stress testing is an optimal way to perform a functional heart examination in dogs. Since it reflects the effects of moderate physical activity, dobutamine has been recommended as the medicine of choice for provoking a pharmacological stress test. This work presents a review of the results of the most important investigations, as well as our own investigations, of the application of the dobutamine stress test (DST) in dogs, and the problems in investigations so far have been considered and future directions for DST investigations pointed out. .

Theophylline and Caffeine as Alternatives During an Aminophylline Shortage

2018 ◽  
Vol 53 (3) ◽  
pp. 316-320 ◽  
Author(s):  
Emily L. Singleton ◽  
Nancy Le ◽  
Genevieve Lynn Ness
Keyword(s):  
Stress Testing ◽  
Stress Test ◽  
Pharmacological Stress ◽  
Drug Shortage ◽  
Reversal Agent ◽  
Cardiac Stress ◽  
Reversal Agents ◽  
Diagnosis And Prognosis ◽  
Pharmacological Stress Testing ◽  
Pharmacological Stress Test

The latest aminophylline shortage has prompted a need for alternative reversal agents for pharmacological stress testing. Cardiac stress testing is common for diagnosis and prognosis in patients with coronary heart disease. Options for pharmacological stress test agents include adenosine, regadenoson, dipyridamole, and dobutamine, whereas aminophylline is the recommended reversal agent. Adenosine and dobutamine can be used as alternatives to regadenoson and dipyridamole to decrease or eliminate the use of aminophylline. Alternatives to aminophylline include theophylline and caffeine. It is important to efficiently identify alternatives during a drug shortage to maintain optimal patient outcomes.

Pharmacological stress testing performed by a clinical technologist

2004 ◽  
Vol 25 (4) ◽  
pp. 408 ◽  
Author(s):  
I. Jones ◽  
J. Thornley ◽  
A. Tukan ◽  
A. McCance
Keyword(s):  
Stress Testing ◽  
Pharmacological Stress ◽  
Pharmacological Stress Testing

Ongoing Continuous Quality Improvement Strategy Using Pharmacological Stress with Intravenous Dipyridamole and Pharmacist Intervention to Reduce Suboptimal Exercise Myocardial Perfusion Scans

1994 ◽  
Vol 7 (3) ◽  
pp. 89-92
Author(s):  
Lisa B. Greenstein ◽  
John L. Hatch ◽  
Thomas P. Sherrin
Keyword(s):  
Heart Rate ◽  
Quality Improvement ◽  
Myocardial Perfusion ◽  
Continuous Quality Improvement ◽  
Stress Testing ◽  
Pharmacist Intervention ◽  
Pharmacological Stress ◽  
Exercise Tests ◽  
Continuous Quality ◽  
Pharmacological Stress Testing

Exercise electrocardiogram (ECG) testing in conjunction with radionuclide imaging provides prognostic, diagnostic, and important physiological information regarding the presence of ischemia. However, many patients cannot or will not exercise to 85% of maximal heart rate. When this occurs, potential disparities in regional myocardial perfusion may not be apparent. Pharmacological stress testing with intravenous (IV) dipyridamole provides an alternative method of increasing intracoronary blood flow in these patients and decreasing the incidence of suboptimal exercise myocardial perfusion scans. An ongoing program was begun in 1992 to determine the effect of using pharmacological stress testing with IV dipyridamole (in selected patients) on the incidence of suboptimal exercise myocardial perfusion scans. Myocardial perfusion scans from the months of February 1991 and February 1992 were reviewed. Data collected included demographic variables, heart rate, percent of maximum predicted heart rate, anti-anginal drug therapy, and any underlying conditions that could influence the patient's ability to exercise adequately. There was only a slight reduction in inadequate exercise tests between the two study periods, 30% in February 1991 and 23% in February 1992, without pharmacist intervention. There was an increase in the number of dipyridamole perfusion scans, one (<1%) in February 1991 and 10 (6%) in February 1992. These data were presented to physicians as part of an educational program on the availability and appropriate use of pharmacological stress testing with IV dipyridamole. Several suggestions were made to assist in decreasing the incidence of suboptimal exercise myocardial perfusion scans. The review was repeated in February 1993. There was a further increase in the number of dipyridamole perfusion scans (18, or 11% over previous levels); however, the rate of suboptimal exercise tests remained at 24%. This review offered an easy and unique opportunity for the pharmacy to be involved in multidisciplinary continuous quality improvement with nuclear medicine and cardiology. It is anticipated that with continued education and a change in patient screening procedures, along with the development and use of drug use guidelines, a decrease in the number of suboptimal exercise myocardial perfusion scans may be realized.

scholarly journals High-Sensitivity Cardiac Troponin T in Stable Patients Undergoing Pharmacological Stress Testing

2015 ◽  
Vol 38 (5) ◽  
pp. 293-299 ◽  
Author(s):  
Nattawut Wongpraparut ◽  
Sudarat Piyophirapong ◽  
Adisak Maneesai ◽  
Kosit Sribhen ◽  
Rungroj Krittayaphong ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Stress Testing ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Pharmacological Stress ◽  
Pharmacological Stress Testing

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

1996 ◽  
Vol 10 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Gamal Abou-Mohamed ◽  
Ravi Nagarajan ◽  
Tarek M. Ibrahim ◽  
Robert W. Caldwell
Keyword(s):  
Stress Testing ◽  
Pharmacological Stress ◽  
Adrenergic Activity ◽  
Pharmacological Stress Testing ◽  
Novel Agent

scholarly journals Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

2021 ◽  
Vol 8 ◽  
Author(s):  
Alessandro Faragli ◽  
Alessio Alogna ◽  
Chong Bin Lee ◽  
Miry Zhu ◽  
Niky Ghorbani ◽  
...  
Keyword(s):  
Stress Testing ◽  
Dobutamine Stress ◽  
Therapeutic Interventions ◽  
Heart Catheterization ◽  
Pharmacological Stress ◽  
Non Invasive ◽  
Myocardial Energetics ◽  
Dobutamine Stress Testing ◽  
Myocardial Efficiency ◽  
Pharmacological Stress Testing

Background: Myocardial efficiency should be maintained stable under light-to-moderate stress conditions, but ischemia puts the myocardium at risk for impaired functionality. Additionally, the measurement of such efficiency typically requires invasive heart catheterization and exposure to ionizing radiation. In this work, we aimed to non-invasively assess myocardial power and the resulting efficiency during pharmacological stress testing and ischemia induction.Methods: In a cohort of n = 10 healthy Landrace pigs, dobutamine stress testing was performed, followed by verapamil-induced ischemia alongside cardiac magnetic resonance (CMR) imaging. External myocardial power, internal myocardial power, and myocardial efficiency were assessed non-invasively using geometrical and functional parameters from CMR volumetric as well as blood flow and pressure measurements.Results: External myocardial power significantly increased under dobutamine stress [2.3 (1.6–3.1) W/m2 vs. 1.3 (1.1–1.6) W/m2, p = 0.005] and significantly decreased under verapamil-induced ischemia [0.8 (0.5–0.9) W/m2, p = 0.005]. Internal myocardial power [baseline: 5.9 (4.6–8.5) W/m2] was not affected by dobutamine [7.5 (6.9–9.0) W/m2, p = 0.241] nor verapamil [5.8 (4.7–8.8) W/m2, p = 0.878]. Myocardial efficiency did not change from baseline to dobutamine [21% (15–27) vs. 31% (20–44), p = 0.059] but decreased significantly during verapamil-induced ischemia [10% (8–13), p = 0.005].Conclusion: In healthy Landrace pigs, dobutamine stress increased external myocardial power, whereas myocardial efficiency was maintained stable. On the contrary, verapamil-induced ischemia substantially decreased external myocardial power and myocardial efficiency. Non-invasive CMR was able to quantify these efficiency losses and might be useful for future clinical studies evaluating the effects of therapeutic interventions on myocardial energetics.

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