scholarly journals Coagulation and fibrinolysis in human acute lung injury-New therapeutic targets?

2005 ◽  
Vol 54 (3) ◽  
pp. 142-149 ◽  
Author(s):  
Lorraine B. Ware ◽  
Julie A. Bastarache ◽  
Ling Wang
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Therapeutic Targets ◽  
New Therapeutic Targets ◽  
Coagulation And Fibrinolysis

Pulmonary coagulation and fibrinolysis in acute lung injury and pneumonia

2005 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Goda Choi ◽  
Esther K. Wolthuis ◽  
Marcel Levi ◽  
Tom Van Der Poll ◽  
Marcus J. Schultz
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Coagulation And Fibrinolysis

Stretching the Search for Therapeutic Targets in Acute Lung Injury

2008 ◽  
Vol 152 (6) ◽  
pp. 255-256
Author(s):  
Patrick Singleton ◽  
Joe G.N. Garcia
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Therapeutic Targets

scholarly journals Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury

Critical Care ◽  
2008 ◽  
Vol 12 (2) ◽  
pp. R41 ◽  
Author(s):  
Dana McClintock ◽  
Hanjing Zhuo ◽  
Nancy Wickersham ◽  
Michael A Matthay ◽  
Lorraine B Ware
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Coagulation And Fibrinolysis

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury

2006 ◽  
Vol 291 (3) ◽  
pp. L307-L311 ◽  
Author(s):  
Lorraine B. Ware ◽  
Eric Camerer ◽  
Karen Welty-Wolf ◽  
Marcus J. Schultz ◽  
Michael A. Matthay
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein C ◽  
Distress Syndrome ◽  
Coagulation Cascade ◽  
Inflammatory Conditions ◽  
Ventilator Induced Lung Injury ◽  
Substantial Progress ◽  
Coagulation And Fibrinolysis ◽  
Made In

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

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