The Making of American Catholicism: Regional Culture and the Catholic Experience argues that regional and transnational relationships have been central to the making of American Catholicism. The book traces the development of Catholic cultures in the South, the Midwest, the West, and the Northeast and their contribution to larger patterns of Catholicism in the United States. Exploring the history of Catholic cultures in New Orleans, Iowa, Wisconsin, Los Angeles, and New York City, the book carefully explores the history of American Catholic cultures across regions and their relation to factors such as national origin, ethnicity, race, and gender. The chapters include close analysis of the historical experiences of Latinx and African American Catholics as well as European immigrant Catholics. Eschewing a national or nationalistic focus that might elide or neglect global connections or local complexity, the book offers an interpretation of the American Catholic experience that encompasses local, national, and transnational histories by emphasizing the diverse origins of Catholics in the United States, their long-standing ties to transnational communities of Catholic believers, and the role of region in shaping the contours of American Catholic religiosity. Drawing on extensive archival research, the book argues that regional American Catholic cultures and a larger American Catholicism developed as transnational Catholic laity and clergy ecclesiastically linked to and by Rome in a hierarchical, authoritarian, and communalistic “universal Church” creatively adapted their devotional and ideological practices in particular American regional contexts that emphasized notions of republicanism, religious liberty, individualistic capitalism, race, ethnicity, and gender.